Abstract：
:In familial searching in forensic genetics, a query DNA profile is tested against a database to determine whether it represents a relative of a database entrant. We examine the potential for using linkage disequilibrium to identify pairs of profiles as belonging to relatives when the query and database rely on nonoverlapping genetic markers. Considering data on individuals genotyped with both microsatellites used in forensic applications and genome-wide SNPs, we find that ∼30%-32% of parent-offspring pairs and ∼35%-36% of sib pairs can be identified from the SNPs of one member of the pair and the microsatellites of the other. The method suggests the possibility of performing familial searches of microsatellite databases using query SNP profiles, or vice versa. It also reveals that privacy concerns arising from computations across multiple databases that share no genetic markers in common entail risks, not only for database entrants, but for their close relatives as well.
journal_name
Celljournal_title
Cellauthors
Kim J,Edge MD,Algee-Hewitt BFB,Li JZ,Rosenberg NAdoi
10.1016/j.cell.2018.09.008subject
Has Abstractpub_date
2018-10-18 00:00:00pages
848-858.e6issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(18)31180-2journal_volume
175pub_type
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