Abstract：
:We have characterized a nondifferentiating mouse muscle cell line, NFB, that represses the activity of the helix-loop-helix (HLH) family of myogenic regulators, yet expresses sarcomeric actins. The NFB MyoD gene is silent, but can be activated upon transfection of a long terminal region-controlled chicken MyoD cDNA, resulting in myogenesis. When NFB cells are fused with H9c2 rat muscle cells in heterokaryons, the level of rat MyoD transcripts declines. Thus, the stoichiometry of MyoD and the putative repressor controls myogenesis. Although NFB cells express myogenin and Myf-5 transcripts, the activity of these regulators is also repressed:myogenesis is not induced in 10T1/2 fibroblasts and is repressed in L6 muscle cells upon fusion with NFB cells. We conclude that the myogenic HLH regulators are not required for sarcomeric actin gene activation and that myogenesis is subject to dominant-negative control.
journal_name
Celljournal_title
Cellauthors
Peterson CA,Gordon H,Hall ZW,Paterson BM,Blau HMdoi
10.1016/0092-8674(90)90014-6subject
Has Abstractpub_date
1990-08-10 00:00:00pages
493-502issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(90)90014-6journal_volume
62pub_type
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