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The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.

Abstract：

:The mouse kreisler (kr) mutation causes segmentation abnormalities in the caudal hindbrain and defective inner ear development. Based on an inversion discovered in the original kr allele, we selected a candidate cDNA highly expressed in the developing caudal hindbrain. This cDNA encodes a basic domain-leucine zipper (bZIP) transcription factor and was confirmed to represent the kr gene by analysis of a second kr allele, generated by chemical mutagenesis, in which a serine is substituted for an asparagine residue conserved in the DNA-binding domain of all known bZIP family members. The identity, expression, and mutant phenotype of kr indicate an early role in axial patterning and provide insights into the molecular and embryologic mechanisms that govern hindbrain and otic development.

journal_name

Cell

journal_title

Cell

authors

Cordes SP,Barsh GS

doi

10.1016/0092-8674(94)90033-7

subject

Has Abstract

pub_date

1994-12-16 00:00:00

pages

1025-34

issue

6

eissn

0092-8674

issn

1097-4172

pii

0092-8674(94)90033-7

journal_volume

79

pub_type

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