Abstract：
:A basic B-cell-specific protein of 35,000 daltons (XM1) is expressed at a high rate--comparable to actin--in resting splenic B lymphocytes of various species. Splenic or thymic T cells or fibroblasts do not express this protein. Upon polyclonal stimulation of B lymphocytes or in proliferating B-lymphocyte-derived cell lines, the synthesis of XM1 is switched off, but it is reinduced by agents that arrest replication, such as mitomycin C, hydroxyurea, ultraviolet light or gamma irradiation. Induction of XM1 after mutagen treatment is fast; the synthesis is regulated on the level of transcription or RNA processing. XM1 is turned over with half-life of less than 2 hr. XM1 is glycosylated. From compartment analysis and Triton solubilization it appears that XM1 is bound to the nuclear membrane.
journal_name
Celljournal_title
Cellauthors
Rahmsdorf HJ,Mallick U,Ponta H,Herrlich Pdoi
10.1016/0092-8674(82)90162-3subject
Has Abstractpub_date
1982-06-01 00:00:00pages
459-68issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(82)90162-3journal_volume
29pub_type
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