Abstract：
:The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR substituted for the androgen receptor (AR) to activate a similar but distinguishable set of target genes and was necessary for maintenance of the resistant phenotype. The GR agonist dexamethasone was sufficient to confer enzalutamide resistance, whereas a GR antagonist restored sensitivity. Acute AR inhibition resulted in GR upregulation in a subset of prostate cancer cells due to relief of AR-mediated feedback repression of GR expression. These findings establish a mechanism of escape from AR blockade through expansion of cells primed to drive AR target genes via an alternative nuclear receptor upon drug exposure.
journal_name
Celljournal_title
Cellauthors
Arora VK,Schenkein E,Murali R,Subudhi SK,Wongvipat J,Balbas MD,Shah N,Cai L,Efstathiou E,Logothetis C,Zheng D,Sawyers CLdoi
10.1016/j.cell.2013.11.012subject
Has Abstractpub_date
2013-12-05 00:00:00pages
1309-22issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01425-6journal_volume
155pub_type
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