Abstract：
:Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal tract, vagal sensory neurons detect gut hormones and organ distension. Here, we investigate the molecular diversity of vagal sensory neurons and their roles in sensing gastrointestinal inputs. Genetic approaches allowed targeted investigation of gut-to-brain afferents involved in homeostatic responses to ingested nutrients (GPR65 neurons) and mechanical distension of the stomach and intestine (GLP1R neurons). Optogenetics, in vivo ganglion imaging, and genetically guided anatomical mapping provide direct links between neuron identity, peripheral anatomy, central anatomy, conduction velocity, response properties in vitro and in vivo, and physiological function. These studies clarify the roles of vagal afferents in mediating particular gut hormone responses. Moreover, genetic control over gut-to-brain neurons provides a molecular framework for understanding neural control of gastrointestinal physiology.
journal_name
Celljournal_title
Cellauthors
Williams EK,Chang RB,Strochlic DE,Umans BD,Lowell BB,Liberles SDdoi
10.1016/j.cell.2016.05.011subject
Has Abstractpub_date
2016-06-30 00:00:00pages
209-21issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(16)30559-1journal_volume
166pub_type
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