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Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B-cell lines.

Abstract：

:We have transferred the mouse Ak alpha and Ak beta genes, which encode the class II I-Ak molecule, into mouse L-cell fibroblasts and hamster B cells. I-Ak molecules are expressed on the surface of both cell types. The L-cell and hamster B-cell I-Ak molecules appear normal by serological analyses and two-dimensional gel electrophoresis. Furthermore, the I-Ak molecules on L cells can act as targets for the allogenic T-cell killing of the transformed L cells. The I-Ak molecules in both mouse fibroblasts and hamster B cells can present certain antigens to T-cell helper hybridomas. Thus only class II molecules are required to convert the nonantigen-presenting cell. Accordingly, it will be possible to dissect the structure-function relationships existing between Ia molecules, foreign antigen, and T-cell receptor molecules by in vitro site-directed mutagenesis and gene transfer.

journal_name

Cell

journal_title

Cell

authors

Malissen B,Price MP,Goverman JM,McMillan M,White J,Kappler J,Marrack P,Pierres A,Pierres M,Hood L

doi

10.1016/0092-8674(84)90225-3

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

319-27

issue

2

eissn

0092-8674

issn

1097-4172

pii

0092-8674(84)90225-3

journal_volume

36

pub_type

杂志文章

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