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Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases.

Abstract：

:We have isolated a dominant mutation in a gene called Son of sevenless (Sos) that is an allele-specific suppressor of the sevenless phenotype. This suppressor function is autonomously required in R7 and is sensitive to the dosage of the Sos and bride of sevenless genes. Loss-of-function alleles of Sos are recessive lethals, but in the eye Sos has a role in R cell development. Mutations in Sos also interact with the Ellipse allele of the Drosophila EGF receptor. We propose a model suggesting that the Sos product is downstream of sevenless and the EGF receptor, and that the dominant suppression results from the overexpression or increased activity of the gene product.

journal_name

Cell

journal_title

Cell

authors

Rogge RD,Karlovich CA,Banerjee U

doi

10.1016/0092-8674(91)90207-f

subject

Has Abstract

pub_date

1991-01-11 00:00:00

pages

39-48

issue

1

eissn

0092-8674

issn

1097-4172

pii

0092-8674(91)90207-F

journal_volume

64

pub_type

杂志文章

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