Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression.

abstract：:We have identified an essential gene, called FIP1, encoding a 327 amino acid protein interacting with yeast poly(A) polymerase (PAP1) in the two-hybrid assay. Recombinant FIP1 protein forms a 1:1 complex with PAP1 in vitro. At 37 degrees C, a thermosensitive allele of FIP1 shows a shortening of poly(A) tails and a dec...

journal_title：Cell

authors： Preker PJ,Lingner J,Minvielle-Sebastia L,Keller W

更新日期：1995-05-05 00:00:00

abstract：:Metastasis is a rare event. Does it arise from rare, variant, highly metastatic cells or does a primary tumor progress to a premalignant state from which metastases arise stochastically without further changes in gene expression? Arguments and evidence have been adduced to support either position. A paper in this mont...

journal_title：Cell

authors： Hynes RO

更新日期：2003-06-27 00:00:00

abstract：:We have reconstituted the fusion and assembly of vesiculated Golgi membranes (VGMs) into functionally active stacks of cisternae. A kinetic analysis of this assembly process revealed that highly dispersed VGMs of 60-90 nm diameter first fuse to form larger vesicles of 200-300 nm diameter that are clustered together. T...

journal_title：Cell

authors： Acharya U,Jacobs R,Peters JM,Watson N,Farquhar MG,Malhotra V

更新日期：1995-09-22 00:00:00

abstract：:The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...

journal_title：Cell

authors： Loeb DM,Maragos J,Martin-Zanca D,Chao MV,Parada LF,Greene LA

更新日期：1991-09-06 00:00:00

abstract：:Cardiomyocytes, the cells of the heart muscle, lose nearly all of their proliferative capacity after birth, limiting the heart's ability to regenerate. Naqvi et al. now identify a transient burst of cardiomyocyte proliferation during preadolescence, driven by a thyroid hormone surge, with therapeutic implications for ...

journal_title：Cell

authors： Palpant NJ,Murry CE

更新日期：2014-05-08 00:00:00

abstract：:Poly(A)-containing RNA, isolated from rat ventral prostate, has been analyzed for its base sequence complexity. The kinetics of hybridization of total cellular poly(A)-containing RNA with its complementary DNA (cDNA) from normal and castrated animals are markedly different. RNA from normal animals consists of three ab...

journal_title：Cell

authors： Parker MG,Mainwaring WI

更新日期：1977-10-01 00:00:00

abstract：:Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria...

journal_title：Cell

authors： Guarente L

更新日期：2008-01-25 00:00:00

abstract：:The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcription...

journal_title：Cell

authors： Ramasamy R,Yan SF,Schmidt AM

更新日期：2006-01-27 00:00:00

abstract：:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differen...

journal_title：Cell

authors： Rhoades MW,Reinhart BJ,Lim LP,Burge CB,Bartel B,Bartel DP

更新日期：2002-08-23 00:00:00

abstract：:Mutations at the X-linked disconnected locus of D. melanogaster lead to the failure of adult photoreceptor axons to innervate their target cells in the developing optic lobes of the third instar larva, resulting in flies that have rudimentary optic ganglia. The cascade of epigenetic events leading to the adult disconn...

journal_title：Cell

authors： Steller H,Fischbach KF,Rubin GM

更新日期：1987-09-25 00:00:00

abstract：:3.18 kb fragments of X. laevis DNA coding for tRNA 1 met have been inserted into a lambda vector via Hind III termini and cloned in E. coli. The organization of one cloned fragment has been analyzed by restriction endonuclease digestion and RNA-DNA hybridization. From the distribution of sites for three enzymes, this ...

journal_title：Cell

authors： Clarkson SG,Kurer V,Smith HO

更新日期：1978-07-01 00:00:00

abstract：:Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such as lateral roots, leaves, and flowers during postembryonic development. Organ primordia develop from founder cell populations into organs by coor...

journal_title：Cell

authors： Benková E,Michniewicz M,Sauer M,Teichmann T,Seifertová D,Jürgens G,Friml J

更新日期：2003-11-26 00:00:00

abstract：:The v-erbB gene product of avian erythroblastosis virus (AEV) has extensive homology with the receptor for epidermal growth factor (EGF). We report here that chicken embryo fibroblasts (CEF) transformed by AEV show enhanced tyrosine phosphorylation of a number of cellular polypeptides, including the 36 kd protein, whi...

journal_title：Cell

authors： Gilmore T,DeClue JE,Martin GS

更新日期：1985-03-01 00:00:00

abstract：:Two papers published in 1984 by the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for degradation of short-lived proteins in mammalian cells, setting the stage for future demonstrations of this pathway's many regulatory roles. This perspective discusses the impact of thos...

journal_title：Cell

authors： Pickart CM

更新日期：2004-01-23 00:00:00

abstract：:The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and ...

journal_title：Cell

authors： Han J,Pedersen JS,Kwon SC,Belair CD,Kim YK,Yeom KH,Yang WY,Haussler D,Blelloch R,Kim VN

更新日期：2009-01-09 00:00:00

abstract：:The fasciclin I, II, and III glycoproteins are expressed on different subsets of axon bundles (fascicles) in insect embryos and are thus candidates for surface recognition molecules involved in growth cone guidance. Here we present the sequence of grasshopper fasciclin I and the identification and sequence of the Dros...

journal_title：Cell

authors： Zinn K,McAllister L,Goodman CS

更新日期：1988-05-20 00:00:00

abstract：:We have shown that lariat formation during in vitro splicing of several RNA precursors, from Drosophila to man, occurs at a unique and identifiable but weakly conserved site, 18 to 37 nucleotides proximal to the 3' splice site. Lariat formation within an artificial intron lacking a normal branch-point sequence occurs ...

journal_title：Cell

authors： Reed R,Maniatis T

更新日期：1985-05-01 00:00:00

abstract：:We show that expression of the iso-1-cytochrome c gene of Saccharomyces cerevisiae, CYC1, is tightly regulated by levels of intracellular heme. Expression is reduced at least 200-fold in cells grown under conditions of heme deficiency. Studies on the regulation of a CYC1-lacZ fused gene and direct determination of mRN...

journal_title：Cell

authors： Guarente L,Mason T

更新日期：1983-04-01 00:00:00

abstract：:Chemotherapy is designed to induce cell death. However, at non-lethal doses, cancer cells can choose to remain proliferative or become senescent. The slow development of senescence makes studying this decision challenging. Here, by analyzing single-cell p21 dynamics before, during, and days after drug treatment, we li...

journal_title：Cell

authors： Hsu CH,Altschuler SJ,Wu LF

更新日期：2019-07-11 00:00:00

abstract：:The cpd mutation localized by T-DNA tagging on Arabidopsis chromosome 5-14.3 inhibits cell elongation controlled by the ecdysone-like brassinosteroid hormone brassinolide. The cpd mutant displays de-etiolation and derepression of light-induced genes in the dark, as well as dwarfism, male sterility, and activation of s...

journal_title：Cell

authors： Szekeres M,Németh K,Koncz-Kálmán Z,Mathur J,Kauschmann A,Altmann T,Rédei GP,Nagy F,Schell J,Koncz C

更新日期：1996-04-19 00:00:00

abstract：:The initiation of chromosome segregation at anaphase is linked by the spindle assembly checkpoint to the completion of chromosome-microtubule attachment during metaphase. To determine the function of the mitotic checkpoint protein Mad2 during normal cell division and when mitosis goes awry, we have knocked out Mad2 in...

journal_title：Cell

authors： Dobles M,Liberal V,Scott ML,Benezra R,Sorger PK

更新日期：2000-06-09 00:00:00

abstract：:The alpha IIb beta 3 integrin binds Arg-Gly-Asp-containing (RGD-containing) ligands in a cation-dependent interaction. A fourteen amino acid sequence, beta 3 (118-131), and an antibody to it, inhibited ligand binding functions of alpha IIb beta 3, and a 1:1 stoichiometric beta 3 (118-131)-RGD complex was detected by m...

journal_title：Cell

authors： D'Souza SE,Haas TA,Piotrowicz RS,Byers-Ward V,McGrath DE,Soule HR,Cierniewski C,Plow EF,Smith JW

更新日期：1994-11-18 00:00:00

abstract：:Proteolytic fragments of human plasma fibronectin were used to identify monoclonal antibodies reacting with the various domains of fibronectin. One of these antibodies, which reacts with cell-attachment-promoting fragments of fibronectin, inhibits attachment of cells to fibronectin-coated surfaces. A cell-attachment-p...

journal_title：Cell

authors： Pierschbacher MD,Hayman EG,Ruoslahti E

更新日期：1981-10-01 00:00:00

abstract：:The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infect...

journal_title：Cell

authors： Sette A,Crotty S

更新日期：2021-01-12 00:00:00

abstract：:Synaptotagmin is one of the major integral membrane proteins of synaptic vesicles. It has been postulated to dock vesicles to their release sites, to act as the Ca2+ sensor for the release process, and to be a fusion protein during exocytosis. To clarify the function of this protein, we have undertaken a genetic analy...

journal_title：Cell

authors： DiAntonio A,Parfitt KD,Schwarz TL

更新日期：1993-07-02 00:00:00

abstract：:In this issue of Cell, Coppens and coworkers (Coppens et al., 2006) describe how Toxoplasma gondii, an obligate intracellular parasite, feeds on the host. Coppens et al. provide evidence that the parasite takes host cell endosomes and lysosomes hostage by sequestering them where the parasite resides, within invaginati...

journal_title：Cell

authors： Gruenberg J,van der Goot FG

更新日期：2006-04-21 00:00:00

abstract：:A transglutaminase-catalyzed cross-linking process characteristic of keratinocytes leads to the formation of the insoluble corneocyte envelope. The essentials of this process take place in vitro in a reconstituted system derived from subcellular fractions. A particulate fraction containing membrane-bound envelope prec...

journal_title：Cell

authors： Simon M,Green H

更新日期：1985-03-01 00:00:00

abstract：:The FoxO transcription factors have been implicated in many processes including tumor suppression and cell death. In this issue, two groups now report on mice that conditionally lack the three predominant FoxO transcription factors. Demonstrate that FoxOs are critical for the long-term maintenance of hematopoietic ste...

journal_title：Cell

authors： Arden KC

更新日期：2007-01-26 00:00:00

abstract：:The ELH prohormone is proteolytically processed into at least nine peptides which govern egg-laying behavior in Aplysia. Quantitative immunocytochemistry demonstrates that peptides derived from the prohormone are packaged into distinct vesicle classes. Further experiments suggest the segregation occurs via a rapid ini...

journal_title：Cell

authors： Fisher JM,Sossin W,Newcomb R,Scheller RH

更新日期：1988-09-09 00:00:00

abstract：:Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) v...

journal_title：Cell

authors： Long JZ,Svensson KJ,Bateman LA,Lin H,Kamenecka T,Lokurkar IA,Lou J,Rao RR,Chang MR,Jedrychowski MP,Paulo JA,Gygi SP,Griffin PR,Nomura DK,Spiegelman BM

更新日期：2016-07-14 00:00:00