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Back to the future with ubiquitin.

Abstract：

:Two papers published in 1984 by the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for degradation of short-lived proteins in mammalian cells, setting the stage for future demonstrations of this pathway's many regulatory roles. This perspective discusses the impact of those papers and highlights some of the subsequent insights that have led to our current appreciation of the breadth of ubiquitin-mediated signaling.

journal_name

Cell

journal_title

Cell

authors

Pickart CM

doi

10.1016/s0092-8674(03)01074-2

subject

Has Abstract

pub_date

2004-01-23 00:00:00

pages

181-90

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092867403010742

journal_volume

116

pub_type

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