How TriC folds tricky proteins.

abstract：:Clonal derivatives of C3HMT murine mammary cell lines in culture demonstrate conversion of mammary tumor virus (MMTV) expression at a rate of appriximately 6 per 100 clones. This alteration is largely unidirectional from a relatively high level (MMTV(H)) to a 10 fold lower level (MMTV(L)). This high rate of MMTV(L) va...

journal_title：Cell

authors： Parks WP,Hubbell ES,Goldberg RJ,O'Neill FJ,Scolnick EM

更新日期：1976-05-01 00:00:00

abstract：:Pulses of ecdysteroids direct Drosophila through its life cycle by activating stage- and tissue-specific genetic regulatory hierarchies. Here we show that an orphan nuclear receptor, DHR78, functions at the top of the ecdysteroid regulatory hierarchies. Null mutations in DHR78 lead to lethality during the third larval...

journal_title：Cell

authors： Fisk GJ,Thummel CS

更新日期：1998-05-15 00:00:00

abstract：:The structure of the complex formed by the arginine-rich motif of the transcriptional antitermination protein N of phage lambda and boxB RNA was determined by heteronuclear magnetic resonance spectroscopy. A bent alpha helix in N recognizes primarily the shape and negatively charged surface of the boxB hairpin through...

journal_title：Cell

authors： Legault P,Li J,Mogridge J,Kay LE,Greenblatt J

更新日期：1998-04-17 00:00:00

abstract：:The intermediate filament proteins, desmin and vimentin, are phosphorylated in skeletal muscle cells in vivo. Desmin kinase activities have been purified from mature chicken skeletal muscle and identified as the cAMP-dependent kinases. Chicken skeletal muscle contains two cAMP-dependent protein kinases which are simil...

journal_title：Cell

authors： O'Connor CM,Gard DL,Lazarides E

更新日期：1981-01-01 00:00:00

abstract：:Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system. We have fractionated mitotic Xenopus egg extracts to identify components required for this process. We find that UBC4 and at least one other ubiquitin-conjugating enzyme can support cyclin B ubiquitination. The mitotic specifici...

journal_title：Cell

authors： King RW,Peters JM,Tugendreich S,Rolfe M,Hieter P,Kirschner MW

更新日期：1995-04-21 00:00:00

abstract：:Our previous deletion experiments have shown that a short region of yeast nuclear gene introns containing the conserved sequence 5'-TACTAACA-3' is essential for splicing. In this report we show that the chemically synthesized decanucleotide 5'-TGTACTAACA-3', when introduced into a hybrid gene forming unspliceable RNA ...

journal_title：Cell

authors： Langford CJ,Klinz FJ,Donath C,Gallwitz D

更新日期：1984-03-01 00:00:00

abstract：:Human evolution is characterized by a dramatic increase in brain size and complexity. To probe its genetic basis, we examined the evolution of genes involved in diverse aspects of nervous system biology. We found that these genes display significantly higher rates of protein evolution in primates than in rodents. Impo...

journal_title：Cell

authors： Dorus S,Vallender EJ,Evans PD,Anderson JR,Gilbert SL,Mahowald M,Wyckoff GJ,Malcom CM,Lahn BT

更新日期：2004-12-29 00:00:00

abstract：:Animal cells can change shape and move by using actin polymerization to drive plasma membrane protrusion. Giannone and coworkers (this issue of Cell) describe how cells periodically pull back on these protrusions in order to sense and respond to the rigidity of their environment. ...

journal_title：Cell

authors： Ridley AJ

更新日期：2004-02-06 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the expression cloning from tumor cells of a third VEGF receptor, one that binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (...

journal_title：Cell

authors： Soker S,Takashima S,Miao HQ,Neufeld G,Klagsbrun M

更新日期：1998-03-20 00:00:00

abstract：:Chimeric histocompatibility genes encoding the amino-terminal (beta 1) domain of the class II Ak beta polypeptide and the carboxy-terminal (C2, transmembrane, and intracytoplasmic) domains of either the class I H-2Ld or H-2Dd molecules were stably introduced into mouse L cells. Although both were transcribed, only 5' ...

journal_title：Cell

authors： McCluskey J,Germain RN,Margulies DH

更新日期：1985-02-01 00:00:00

abstract：:We analyzed a family of proteins from hepatoma cell nuclei that bind to interleukin-6 responsive elements (IL-6REs) of several acute-phase genes. This family is characterized by leucine zipper domains compatible with that of the CCAAT/enhancer binding protein (C/EBP). A cDNA clone coding for a member of the family, IL...

journal_title：Cell

authors： Poli V,Mancini FP,Cortese R

更新日期：1990-11-02 00:00:00

abstract：:Procollagen and collagen were isolated from the culture medium and cell layer of line TSD4 (obtained from mouse teratocarcinoma OTT6050). SDS-polyacrylamide gel electrophoresis of the highly purified procollagen fraction demonstrated that the fraction is composed of theta chains (150,000 daltons), pro alpha chains (13...

journal_title：Cell

authors： Little CD,Church RL,Miller RA,Ruddle FH

更新日期：1977-02-01 00:00:00

abstract：:Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination. ...

journal_title：Cell

authors： Bernstein KA,Rothstein R

更新日期：2009-05-29 00:00:00

abstract：:The S. cerevisiae CLN genes encode cyclin homologs essential for progression from G1 to S phase. The CLN2 gene encodes a 62 kd polypeptide that accumulates periodically, peaking during G1 and decreasing rapidly thereafter, and is rapidly lost following exposure of cells to mating pheromone. Cln2 abundance can be expla...

journal_title：Cell

authors： Wittenberg C,Sugimoto K,Reed SI

更新日期：1990-07-27 00:00:00

abstract：:Mitochondrial DNA is compacted into nucleoprotein complexes denoted mitochondrial nucleoids, the focus of this SnapShot. ...

journal_title：Cell

authors： Bonekamp NA,Larsson NG

更新日期：2018-01-11 00:00:00

abstract：:Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persis...

journal_title：Cell

authors： Kochanowsky JA,Koshy AA

更新日期：2020-01-23 00:00:00

abstract：:Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal signals across multiple neuronal cell types. Here, we combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity...

journal_title：Cell

authors： Yang Y,Atasoy D,Su HH,Sternson SM

更新日期：2011-09-16 00:00:00

abstract：:We have examined the long-range distribution of double-stranded DNA cleavage sites for Drosophila melanogaster topoisomerase II. These studies reveal a novel partitioning of preferred topoisomerase II cleavage sites. In the eukaryotic DNAs examined, major cleavage sites were typically found in nontranscribed spacer se...

journal_title：Cell

authors： Udvardy A,Schedl P,Sander M,Hsieh TS

更新日期：1985-04-01 00:00:00

abstract：:Centrosome duplication is a critical step in assembly of the bipolar mitotic spindle, but the molecular mechanisms regulating this process during the cell cycle and during animal development are poorly understood. Here, we report that the zyg-1 gene of Caenorhabditis elegans is an essential regulator of centrosome dup...

journal_title：Cell

authors： O'Connell KF,Caron C,Kopish KR,Hurd DD,Kemphues KJ,Li Y,White JG

更新日期：2001-05-18 00:00:00

abstract：:The Origin Recognition Complex (ORC) is a six-protein assembly that specifies the sites of DNA replication initiation in S. cerevisiae. Origin recognition by ORC requires ATP. Here, we demonstrate that two subunits, Orc1p and Orc5p, bind ATP and that Orc1p also hydrolyzes ATP. ATP binding and hydrolysis by Orc1p are b...

journal_title：Cell

authors： Klemm RD,Austin RJ,Bell SP

更新日期：1997-02-21 00:00:00

abstract：:In this issue of Cell, Lee et al. (2006) report that the parasite Trypanosoma brucei synthesizes fatty acids in an unconventional way. T. brucei and two other trypanosomes use enzymes called elongases to synthesize myristate, a fourteen carbon (C14) fatty acid essential for pathogenesis. This is an unexpected finding ...

journal_title：Cell

authors： Cronan JE

更新日期：2006-08-25 00:00:00

abstract：:DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide produc...

journal_title：Cell

authors： Mellor AL,Weiss EH,Kress M,Jay G,Flavell RA

更新日期：1984-01-01 00:00:00

abstract：:Mutant strains of D. discoideum are described that can complete morphogenesis and cytodifferentiation but which express vastly reduced levels of the galactose-binding lectins discoidin I and II (less than 1% and 1%-2% respectively) compared to the wild-type control. Mutant cells proceeding through development lack lec...

journal_title：Cell

authors： Alexander S,Shinnick TM,Lerner RA

更新日期：1983-09-01 00:00:00

abstract：:Exit from mitosis must not occur prior to partitioning of chromosomes between daughter cells. We find that the GTP binding protein Tem1, a regulator of mitotic exit, is present on the spindle pole body that migrates into the bud during S phase and mitosis. Tem1's exchange factor, Lte1, localizes to the bud. Thus, Tem1...

journal_title：Cell

authors： Bardin AJ,Visintin R,Amon A

更新日期：2000-07-07 00:00:00

abstract：:Activating mutations of FLT3 occur in about 30% of acute myeloid leukemia (AML) cases and are associated with relapse and poor prognosis. Midostaurin is the first drug approved for AML since 2000, and the first multi-kinase inhibitor approved for the FLT3-mutant subtype. To view this Bench to Bedside, open or download...

journal_title：Cell

authors： Rasko JEJ,Hughes TP

更新日期：2017-11-16 00:00:00

abstract：:Determining which neurite of a differentiating neuron is to become the axon is a crucial step in neuronal morphogenesis. Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1. ...

journal_title：Cell

authors： Winckler B

更新日期：2007-05-04 00:00:00

abstract：:Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization. Prominently, the left-right asymmetry was randomized in the heart loop and the direction of embry...

journal_title：Cell

authors： Nonaka S,Tanaka Y,Okada Y,Takeda S,Harada A,Kanai Y,Kido M,Hirokawa N

更新日期：1998-12-11 00:00:00

abstract：:NF-kappaB, a key regulator of the cellular inflammatory and immune response, is activated by the HTLV-I transforming and transactivating protein Tax. We show that Tax binds to the amino terminus of the protein kinase MEKK1, a component of an IkappaB kinase complex, and stimulates MEKK1 kinase activity. Tax expression ...

journal_title：Cell

authors： Yin MJ,Christerson LB,Yamamoto Y,Kwak YT,Xu S,Mercurio F,Barbosa M,Cobb MH,Gaynor RB

更新日期：1998-05-29 00:00:00

abstract：:The majority of the mRNA molecules in HeLa cells contain 1-2 residue(s) of m6Ap and one blocked, methylated 5' terminal "cap" structure. The hnRNA, which is longer than mRNA, contains both m6Ap and caps but 4-6 times as many m6Ap residues per chain. In addition, nuclear molecules contain T2 RNA ase-resistant, methyl-l...

journal_title：Cell

authors： Salditt-Georgieff M,Jelinek W,Darnell JE,Furuichi Y,Morgan M,Shatkin A

更新日期：1976-02-01 00:00:00

abstract：:The messenger RNA coding for the precursor of the small subunit of ribulose--1,5--bisphosphate (Ru-P2) carboxylase has been partially purified from pea leaves. The mRNA has a size of 11.5S, is approximately 800 nucleotides long and, on cell-free translation, directs the synthesis of a single major polypeptide of 20,00...

journal_title：Cell

authors： Cashmore AR

更新日期：1979-06-01 00:00:00