Abstract：
:Synaptic plasticity in response to changes in physiologic state is coordinated by hormonal signals across multiple neuronal cell types. Here, we combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity onto AGRP neurons, a population that regulates feeding. We find that food deprivation elevates excitatory synaptic input, which is mediated by a presynaptic positive feedback loop involving AMP-activated protein kinase. Potentiation of glutamate release was triggered by the orexigenic hormone ghrelin and exhibited hysteresis, persisting for hours after ghrelin removal. Persistent activity was reversed by the anorexigenic hormone leptin, and optogenetic photostimulation demonstrated involvement of opioid release from POMC neurons. Based on these experiments, we propose a memory storage device for physiological state constructed from bistable synapses that are flipped between two sustained activity states by transient exposure to hormones signaling energy levels.
journal_name
Celljournal_title
Cellauthors
Yang Y,Atasoy D,Su HH,Sternson SMdoi
10.1016/j.cell.2011.07.039subject
Has Abstractpub_date
2011-09-16 00:00:00pages
992-1003issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(11)00882-8journal_volume
146pub_type
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