New surface component of fibroblast's focal contacts identified by a monoclonal antibody.

abstract：:The recognition of specific DNA-binding sites by transcription factors is a critical yet poorly understood step in the control of gene expression. Members of the Hox family of transcription factors bind DNA by making nearly identical major groove contacts via the recognition helices of their homeodomains. In vivo spec...

journal_title：Cell

authors： Joshi R,Passner JM,Rohs R,Jain R,Sosinsky A,Crickmore MA,Jacob V,Aggarwal AK,Honig B,Mann RS

更新日期：2007-11-02 00:00:00

abstract：:Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 comp...

journal_title：Cell

authors： Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR

更新日期：2020-05-28 00:00:00

abstract：:Receptor-mediated endocytosis of specific ligands is mediated through clustering of receptor-ligand complexes in coated pits on the cell surface. Following this clustering event, the ligand is internalized into a noncoated intracellular vesicle, the receptosome, which selectively avoids fusion with lysosomes and moves...

journal_title：Cell

authors： Willingham MC,Pastan I

更新日期：1980-08-01 00:00:00

abstract：:Advances in genomic technology have produced an explosion of new information about the genetic basis for human disease, fueling extraordinarily high expectations for improved treatments. This perspective will take brief stock of what genetics/genomics have brought to clinical practice to date and what we might expect ...

journal_title：Cell

authors： Ginsburg D

更新日期：2011-09-30 00:00:00

abstract：:We describe the purification and characterization of ACF, an ATP-utilizing chromatin assembly and remodeling factor. ACF is a multisubunit factor that contains ISWI protein and is distinct from NURF, another ISWI-containing factor. In chromatin assembly, purified ACF and a core histone chaperone (such as NAP-1 or CAF-...

journal_title：Cell

authors： Ito T,Bulger M,Pazin MJ,Kobayashi R,Kadonaga JT

更新日期：1997-07-11 00:00:00

abstract：:A novel method of affinity chromatography on insolubilized collagen-binding fragments of fibronectin was utilized to isolate a random-coil collagenous protein from culture media of mouse teratocarcinoma-derived endodermal cells. These cells also produced another collagenous protein, which did not bind to fibronectin b...

journal_title：Cell

authors： Engvall E,Bell ML,Carlsson RN,Miller EJ,Ruoslahti E

更新日期：1982-06-01 00:00:00

abstract：:This year's Lasker-Bloomberg Public Service Award goes to GAVI, the Vaccine Alliance, for providing sustained access to childhood vaccines around the globe, saving millions of lives, and highlighting the power of immunization to prevent disease. ...

journal_title：Cell

authors： Zerhouni E

更新日期：2019-09-19 00:00:00

abstract：:Chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chromatin domains remain po...

journal_title：Cell

authors： Blackledge NP,Farcas AM,Kondo T,King HW,McGouran JF,Hanssen LLP,Ito S,Cooper S,Kondo K,Koseki Y,Ishikura T,Long HK,Sheahan TW,Brockdorff N,Kessler BM,Koseki H,Klose RJ

更新日期：2014-06-05 00:00:00

abstract：:Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes. A repressor form of Ci arises in the absence of Hh signaling by proteolytic cleavage of intact...

journal_title：Cell

authors： Méthot N,Basler K

更新日期：1999-03-19 00:00:00

abstract：:Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonst...

journal_title：Cell

authors： Muller PA,Koscsó B,Rajani GM,Stevanovic K,Berres ML,Hashimoto D,Mortha A,Leboeuf M,Li XM,Mucida D,Stanley ER,Dahan S,Margolis KG,Gershon MD,Merad M,Bogunovic M

更新日期：2014-07-17 00:00:00

abstract：:Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of approximately 30%. AC5 KO mice are protected from red...

journal_title：Cell

authors： Yan L,Vatner DE,O'Connor JP,Ivessa A,Ge H,Chen W,Hirotani S,Ishikawa Y,Sadoshima J,Vatner SF

更新日期：2007-07-27 00:00:00

abstract：:The yeast tropomyosin gene, designated TPM1, is present in a single copy per haploid genome and encodes a protein with a predicted molecular weight of 23.5 kd. The protein sequence is homologous to higher cell tropomyosins, including the characteristic hydrophobic-hydrophilic pseudoheptapeptide repeats. Indirect immun...

journal_title：Cell

authors： Liu HP,Bretscher A

更新日期：1989-04-21 00:00:00

abstract：:Here we characterize the T-cell-activating protein (TAP), an Ly-6 gene product involved in T cell activation, as a glycoprotein with a molecular weight of 10-12 kd under nonreducing conditions and 15-18 kd under reducing ones. Two of the three bands that are precipitated from metabolically labeled cells are expressed ...

journal_title：Cell

authors： Reiser H,Oettgen H,Yeh ET,Terhorst C,Low MG,Benacerraf B,Rock KL

更新日期：1986-11-07 00:00:00

abstract：:Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that ...

journal_title：Cell

authors： Hall AC,Lucas FR,Salinas PC

更新日期：2000-03-03 00:00:00

abstract：:The actions and receptor for ciliary neurotrophic factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor components, CNTFR alpha, is expressed by skeletal muscle. Here we show that the other CNTF receptor components, LIFR beta and gp130, are also expressed by skeletal mu...

journal_title：Cell

authors： Helgren ME,Squinto SP,Davis HL,Parry DJ,Boulton TG,Heck CS,Zhu Y,Yancopoulos GD,Lindsay RM,DiStefano PS

更新日期：1994-02-11 00:00:00

abstract：:During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry. ...

journal_title：Cell

authors： Chernomordik LV,Kozlov MM

更新日期：2005-11-04 00:00:00

abstract：:Proteins, particularly viral proteins, can be multifunctional, but the mechanisms behind multifunctionality are not fully understood. Here, we illustrate through multiple crystal structures, biochemistry, and cellular microscopy that VP40 rearranges into different structures, each with a distinct function required for...

journal_title：Cell

authors： Bornholdt ZA,Noda T,Abelson DM,Halfmann P,Wood MR,Kawaoka Y,Saphire EO

更新日期：2013-08-15 00:00:00

abstract：:Vaccinia virus recombinants were generated which express the intact gp70/p15E of Friend mink cell focus inducing virus (F-MCFV) or truncated forms of the glycoprotein that lack the transmembrane and cytoplasmic domains. The transport of the intact and truncated envelope glycoproteins to apical or basolateral surfaces ...

journal_title：Cell

authors： Stephens EB,Compans RW

更新日期：1986-12-26 00:00:00

abstract：:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it mea...

journal_title：Cell

authors： Sánchez Alvarado A,Yamanaka S

更新日期：2014-03-27 00:00:00

abstract：:Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during agi...

journal_title：Cell

authors： Walther DM,Kasturi P,Zheng M,Pinkert S,Vecchi G,Ciryam P,Morimoto RI,Dobson CM,Vendruscolo M,Mann M,Hartl FU

更新日期：2015-05-07 00:00:00

abstract：:Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...

journal_title：Cell

authors： Joyce MG,Wheatley AK,Thomas PV,Chuang GY,Soto C,Bailer RT,Druz A,Georgiev IS,Gillespie RA,Kanekiyo M,Kong WP,Leung K,Narpala SN,Prabhakaran MS,Yang ES,Zhang B,Zhang Y,Asokan M,Boyington JC,Bylund T,Darko S,Lees

更新日期：2016-07-28 00:00:00

abstract：:Radioactive alpha factor is degraded to discrete biologically inactive fragments by the target a cells of S. cerevisiae, but not by alpha cells which make the pheromone. The pattern of cleavage products and sequence analysis of one fragment indicated that the first scission occurred between leucine 6 and lysine 7. The...

journal_title：Cell

authors： Ciejek E,Thorner J

更新日期：1979-11-01 00:00:00

abstract：:Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...

journal_title：Cell

authors： Stoolman JS,Chandel NS

更新日期：2019-06-27 00:00:00

abstract：:Elements controlling tissue-specific expression of the rat albumin gene reside within roughly 150 bp upstream of the transcriptional initiation site. We show here by DNAase I footprinting assays that at least four distinct factors present in extracts derived from cells expressing albumin interact with these sequences....

journal_title：Cell

authors： Cereghini S,Raymondjean M,Carranca AG,Herbomel P,Yaniv M

更新日期：1987-08-14 00:00:00

abstract：:Different species of fruit flies share habitats but are believed to mate with each other only rarely. In this issue, Fan et al. show that interspecies mating is inhibited by the taste receptor Gr32a (Gustatory receptor 32a) and a neural circuit in which it functions. ...

journal_title：Cell

authors： Koh TW,Carlson JR

更新日期：2013-07-03 00:00:00

abstract：:Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon and pigmentary disorders in mice and humans. We report that a targeted disruption of the mouse endothelin-3 ligand (EDN3) gene produces a similar recessive phenotype of megacolon and coat color spotting. A natural recessive mutation t...

journal_title：Cell

authors： Baynash AG,Hosoda K,Giaid A,Richardson JA,Emoto N,Hammer RE,Yanagisawa M

更新日期：1994-12-30 00:00:00

abstract：:cDNA clones of the Drosophila epidermal growth factor receptor homolog (DER) gene were isolated and sequenced. The deduced amino acid sequence shows a similar degree of homology to the human epidermal growth factor receptor and to the rat and human neu proteins; the most striking difference is the addition of a third ...

journal_title：Cell

authors： Schejter ED,Segal D,Glazer L,Shilo BZ

更新日期：1986-09-26 00:00:00

abstract：:Mutants in bacterial topoisomerase (topo) IV are deficient in chromosomal partitioning. To investigate the basis of this phenotype, we examined plasmid DNA topology in conditionally lethal topo IV mutants. We found that dimeric catenated plasmids accumulated in vivo after topo IV inhibition. The catenanes were superco...

journal_title：Cell

authors： Adams DE,Shekhtman EM,Zechiedrich EL,Schmid MB,Cozzarelli NR

更新日期：1992-10-16 00:00:00

abstract：:Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endot...

journal_title：Cell

authors： Iwasaki A,Medzhitov R

更新日期：2011-09-16 00:00:00

abstract：:Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vγ5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene express...

journal_title：Cell

authors： Di Marco Barros R,Roberts NA,Dart RJ,Vantourout P,Jandke A,Nussbaumer O,Deban L,Cipolat S,Hart R,Iannitto ML,Laing A,Spencer-Dene B,East P,Gibbons D,Irving PM,Pereira P,Steinhoff U,Hayday A

更新日期：2016-09-22 00:00:00