Abstract:
:Here we characterize the T-cell-activating protein (TAP), an Ly-6 gene product involved in T cell activation, as a glycoprotein with a molecular weight of 10-12 kd under nonreducing conditions and 15-18 kd under reducing ones. Two of the three bands that are precipitated from metabolically labeled cells are expressed on the cell surface and can be recovered from the supernatants of cells treated with a phosphatidylinositol-specific phospholipase C. Thus TAP appears to be attached to the cell membrane via this lipid. Precisely the same anchorage is observed for the activating Thy-1 molecule, and is therefore of particular interest as a potentially novel linkage involved in membrane signal transduction.
journal_name
Celljournal_title
Cellauthors
Reiser H,Oettgen H,Yeh ET,Terhorst C,Low MG,Benacerraf B,Rock KLdoi
10.1016/0092-8674(86)90593-3subject
Has Abstractpub_date
1986-11-07 00:00:00pages
365-70issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(86)90593-3journal_volume
47pub_type
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