A secondary attachment site for bacteriophage lambda in trpC of E. coli.

abstract：:We have determined the nucleotide sequence of the transposable maize controlling element Activator (Ac). The Ac element is 4563 bp long and has an imperfect terminal repetition of 11 bp. The element contains two open reading frames (ORF) encoding polypeptides of 839 and 210 amino acids. Evidence derived from structura...

journal_title：Cell

authors： Pohlman RF,Fedoroff NV,Messing J

更新日期：1984-06-01 00:00:00

abstract：:The ClyA protein is a pore-forming cytotoxin expressed by Escherichia coli and some other enterobacteria. It confers cytotoxic activity toward mammalian cells, but it has remained unknown how ClyA is surface exposed and exported from bacterial cells. Outer-membrane vesicles (OMVs) released from the bacteria were shown...

journal_title：Cell

authors： Wai SN,Lindmark B,Söderblom T,Takade A,Westermark M,Oscarsson J,Jass J,Richter-Dahlfors A,Mizunoe Y,Uhlin BE

更新日期：2003-10-03 00:00:00

abstract：:Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify additional clock genes and modifiers, we conducted a genome-wide small interfering RNA screen in a human cellular clock model. Knockdown of nearly 1000 genes reduc...

journal_title：Cell

authors： Zhang EE,Liu AC,Hirota T,Miraglia LJ,Welch G,Pongsawakul PY,Liu X,Atwood A,Huss JW 3rd,Janes J,Su AI,Hogenesch JB,Kay SA

更新日期：2009-10-02 00:00:00

abstract：:Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that...

journal_title：Cell

authors： Hall HE,Hawley RS

更新日期：2009-09-04 00:00:00

abstract：:Acquisition of the ability to produce and respond to a growth factor may result in increased cellular proliferation and could lead to malignant transformation. The fact that a large variety of tumor cells secrete transforming growth factor-alpha (TGF-alpha) suggests involvement of TGF-alpha in cellular transformation ...

journal_title：Cell

authors： Rosenthal A,Lindquist PB,Bringman TS,Goeddel DV,Derynck R

更新日期：1986-07-18 00:00:00

abstract：:Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...

journal_title：Cell

authors： Joyce MG,Wheatley AK,Thomas PV,Chuang GY,Soto C,Bailer RT,Druz A,Georgiev IS,Gillespie RA,Kanekiyo M,Kong WP,Leung K,Narpala SN,Prabhakaran MS,Yang ES,Zhang B,Zhang Y,Asokan M,Boyington JC,Bylund T,Darko S,Lees

更新日期：2016-07-28 00:00:00

abstract：:PD-1 immune checkpoint blockade provides significant clinical benefits for melanoma patients. We analyzed the somatic mutanomes and transcriptomes of pretreatment melanoma biopsies to identify factors that may influence innate sensitivity or resistance to anti-PD-1 therapy. We find that overall high mutational loads a...

journal_title：Cell

authors： Hugo W,Zaretsky JM,Sun L,Song C,Moreno BH,Hu-Lieskovan S,Berent-Maoz B,Pang J,Chmielowski B,Cherry G,Seja E,Lomeli S,Kong X,Kelley MC,Sosman JA,Johnson DB,Ribas A,Lo RS

更新日期：2016-03-24 00:00:00

abstract：:We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal...

journal_title：Cell

authors： Bassing CH,Suh H,Ferguson DO,Chua KF,Manis J,Eckersdorff M,Gleason M,Bronson R,Lee C,Alt FW

更新日期：2003-08-08 00:00:00

abstract：:Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA ...

journal_title：Cell

authors： Reinisch KM,Chen L,Verdine GL,Lipscomb WN

更新日期：1995-07-14 00:00:00

abstract：:In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting a...

journal_title：Cell

authors： He X

更新日期：2005-01-28 00:00:00

abstract：:AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are ...

journal_title：Cell

authors： Shi S,Hayashi Y,Esteban JA,Malinow R

更新日期：2001-05-04 00:00:00

abstract：:We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...

journal_title：Cell

authors： Klein R,Smeyne RJ,Wurst W,Long LK,Auerbach BA,Joyner AL,Barbacid M

更新日期：1993-10-08 00:00:00

abstract：:Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regula...

journal_title：Cell

authors： Wrana JL

更新日期：2009-01-09 00:00:00

abstract：:Epigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and f...

journal_title：Cell

authors： Calarco JP,Borges F,Donoghue MT,Van Ex F,Jullien PE,Lopes T,Gardner R,Berger F,Feijó JA,Becker JD,Martienssen RA

更新日期：2012-09-28 00:00:00

abstract：:The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...

journal_title：Cell

authors： Zhu PJ,Huang W,Kalikulov D,Yoo JW,Placzek AN,Stoica L,Zhou H,Bell JC,Friedlander MJ,Krnjević K,Noebels JL,Costa-Mattioli M

更新日期：2011-12-09 00:00:00

abstract：:Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previ...

journal_title：Cell

authors： Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

更新日期：2018-01-25 00:00:00

abstract：:Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circa...

journal_title：Cell

authors： Mukherji A,Kobiita A,Ye T,Chambon P

更新日期：2013-05-09 00:00:00

abstract：:The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection, and because the human population does not have pre-existing immunity to the H7 subtype. Earlier sequence analyses of H7N9 hemagglutinin (HA) point to amin...

journal_title：Cell

authors： Tharakaraman K,Jayaraman A,Raman R,Viswanathan K,Stebbins NW,Johnson D,Shriver Z,Sasisekharan V,Sasisekharan R

更新日期：2013-06-20 00:00:00

abstract：:gamma-Irradiation of human diploid fibroblasts in the G1 interval caused arrest of the cell cycle prior to S phase. This cell cycle block was correlated with a lack of activation of both cyclin E-Cyclin-dependent kinase 2 (Cdk2) and cyclin A-Cdk2 kinases and depended on wild-type p53. Although the accumulation of cycl...

journal_title：Cell

authors： Dulić V,Kaufmann WK,Wilson SJ,Tlsty TD,Lees E,Harper JW,Elledge SJ,Reed SI

更新日期：1994-03-25 00:00:00

abstract：:Resident proteins of the ER lumen carry a specific tetrapeptide signal (KDEL or HDEL) that prevents their secretion. We have previously described the isolation of yeast mutants that fail to retain such resident proteins within the cell. Here we describe ERD2, a gene required for retention. It encodes a 26 kd integral ...

journal_title：Cell

authors： Semenza JC,Hardwick KG,Dean N,Pelham HR

更新日期：1990-06-29 00:00:00

abstract：:During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far slower reaction results ...

journal_title：Cell

authors： Kim B,Little JW

更新日期：1993-06-18 00:00:00

abstract：:Cellular functioning requires the orchestration of thousands of molecular interactions in time and space. Yet most molecules in a cell move by diffusion, which is sensitive to external factors like temperature. How cells sustain complex, diffusion-based systems across wide temperature ranges is unknown. Here, we uncov...

journal_title：Cell

authors： Persson LB,Ambati VS,Brandman O

更新日期：2020-12-10 00:00:00

abstract：:Using X-ray crystallography, we have directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution. About 30 nucleotides of the mRNA are wrapped in a groove that encircles the neck of the 30S subunit. The Shine-Dalgarno helix is bound in a large cleft between the head and the back...

journal_title：Cell

authors： Yusupova GZ,Yusupov MM,Cate JH,Noller HF

更新日期：2001-07-27 00:00:00

abstract：:This year, the Albert Lasker Basic Medical Research Award will be shared by Michael Sheetz, James Spudich, and Ronald Vale for discoveries concerning the biophysical actions of cytoskeletal motor-protein machines that move cargo within cells, contract muscles, and enable cell motility. ...

journal_title：Cell

authors： Ringe D,Petsko GA

更新日期：2012-09-14 00:00:00

abstract：:The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processing, but the computations within the LH-VTA loop that give rise to specific aspects of behavior have been difficult to isolate. We show that LH-VTA neurons encode the learned action of seeking a reward, indepe...

journal_title：Cell

authors： Nieh EH,Matthews GA,Allsop SA,Presbrey KN,Leppla CA,Wichmann R,Neve R,Wildes CP,Tye KM

更新日期：2015-01-29 00:00:00

abstract：:The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED micros...

journal_title：Cell

authors： Tønnesen J,Inavalli VVGK,Nägerl UV

更新日期：2018-02-22 00:00:00

abstract：:We have purified and characterized a modified peptide pheromone that accumulates in culture medium as B. subtilis grows to high density. This pheromone is required for the development of genetic competence. When added to cells at low density, the pheromone induces the premature development of competence. The peptide m...

journal_title：Cell

authors： Magnuson R,Solomon J,Grossman AD

更新日期：1994-04-22 00:00:00

abstract：:We have previously cloned lethal(2)giant larvae, a tumor-suppressor gene of Drosophila that normally controls cell proliferation and/or differentiation in the optic centers of the brain and the imaginal discs. Here we describe the structure of the l(2)gl genes as determined by sequencing genomic and cDNA clones. The s...

journal_title：Cell

authors： Jacob L,Opper M,Metzroth B,Phannavong B,Mechler BM

更新日期：1987-07-17 00:00:00

abstract：:Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19(th) century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of unde...

journal_title：Cell

authors： Kretzschmar K,Watt FM

更新日期：2012-01-20 00:00:00

abstract：:The amino acid glutamine has a central role in nitrogen metabolism. Although the molecular mechanisms responsible for its transport across cell membranes remain poorly understood, classical amino acid transport system N appears particularly important. Using intracellular pH measurements, we have now identified an orph...

journal_title：Cell

authors： Chaudhry FA,Reimer RJ,Krizaj D,Barber D,Storm-Mathisen J,Copenhagen DR,Edwards RH

更新日期：1999-12-23 00:00:00