Abstract:
:Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.
journal_name
Celljournal_title
Cellauthors
Wrana JLdoi
10.1016/j.cell.2008.12.028subject
Has Abstractpub_date
2009-01-09 00:00:00pages
13-4issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(08)01634-6journal_volume
136pub_type
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