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The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.

Abstract：

:We have cloned the C. elegans cell death gene ced-3. A ced-3 transcript is most abundant during embryogenesis, the stage during which most programmed cell deaths occur. The predicted CED-3 protein shows similarity to human and murine interleukin-1 beta-converting enzyme and to the product of the mouse nedd-2 gene, which is expressed in the embryonic brain. The sequences of 12 ced-3 mutations as well as the sequences of ced-3 genes from two related nematode species identify sites of potential functional importance. We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals.

journal_name

Cell

journal_title

Cell

authors

Yuan J,Shaham S,Ledoux S,Ellis HM,Horvitz HR

doi

10.1016/0092-8674(93)90485-9

subject

Has Abstract

pub_date

1993-11-19 00:00:00

pages

641-52

issue

4

eissn

0092-8674

issn

1097-4172

pii

0092-8674(93)90485-9

journal_volume

75

pub_type

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