Abstract：
:The Escherichia coli relBE operon encodes a toxin-antitoxin pair, RelE-RelB. RelB can reverse inhibition of protein synthesis by RelE in vivo. We have found that although RelE does not degrade free RNA, it cleaves mRNA in the ribosomal A site with high codon specificity. Among stop codons UAG is cleaved with fast, UAA intermediate and UGA slow rate, while UCG and CAG are cleaved most rapidly among sense codons. We suggest that inhibition of protein synthesis by RelE is reversed with the help of tmRNA, and that RelE plays a regulatory role in bacteria during adaptation to poor growth conditions.
journal_name
Celljournal_title
Cellauthors
Pedersen K,Zavialov AV,Pavlov MY,Elf J,Gerdes K,Ehrenberg Mdoi
10.1016/s0092-8674(02)01248-5subject
Has Abstractpub_date
2003-01-10 00:00:00pages
131-40issue
1eissn
0092-8674issn
1097-4172pii
S0092867402012485journal_volume
112pub_type
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