Niche crosstalk: intercellular signals at the hair follicle.

abstract：:Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We u...

journal_title：Cell

authors： Shah PS,Link N,Jang GM,Sharp PP,Zhu T,Swaney DL,Johnson JR,Von Dollen J,Ramage HR,Satkamp L,Newton B,Hüttenhain R,Petit MJ,Baum T,Everitt A,Laufman O,Tassetto M,Shales M,Stevenson E,Iglesias GN,Shokat L,Tripathi

更新日期：2018-12-13 00:00:00

abstract：:In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. These kinases coordinately regulate various cellular ...

journal_title：Cell

authors： Steffen KK,MacKay VL,Kerr EO,Tsuchiya M,Hu D,Fox LA,Dang N,Johnston ED,Oakes JA,Tchao BN,Pak DN,Fields S,Kennedy BK,Kaeberlein M

更新日期：2008-04-18 00:00:00

abstract：:A major challenge to understanding how cells work together in the central nervous system (CNS) is the heterogeneous cellular composition of the brain. In this issue, Heiman et al. (2008) and Doyle et al. (2008) introduce a new strategy (TRAP) that enables the profiling of translated mRNAs in specific CNS cell populati...

journal_title：Cell

authors： Emery B,Barres BA

更新日期：2008-11-14 00:00:00

abstract：:Analysis of the in vitro splicing products of RNA precursors containing tandem duplications of the 5' or 3' splice sites of human beta-globin IVS 1 revealed that exon sequences play an important role in the relative use of the duplicated sites. These studies also show that the proximity of the 5' and 3' splice sites i...

journal_title：Cell

authors： Reed R,Maniatis T

更新日期：1986-08-29 00:00:00

abstract：:Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcripti...

journal_title：Cell

authors： Shorter J

更新日期：2017-09-21 00:00:00

abstract：:Pathogenic Vibrio cholerae remains a major human health concern. V. cholerae has a characteristic curved rod morphology, with a longer outer face and a shorter inner face. The mechanism and function of this curvature were previously unknown. Here, we identify and characterize CrvA, the first curvature determinant in V...

journal_title：Cell

authors： Bartlett TM,Bratton BP,Duvshani A,Miguel A,Sheng Y,Martin NR,Nguyen JP,Persat A,Desmarais SM,VanNieuwenhze MS,Huang KC,Zhu J,Shaevitz JW,Gitai Z

更新日期：2017-01-12 00:00:00

abstract：:We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule...

journal_title：Cell

authors： Lee JO,Rieu P,Arnaout MA,Liddington R

更新日期：1995-02-24 00:00:00

abstract：:Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceosome, which removes noncoding introns from precursor messenger RNAs (pre-mRNAs), follows fundamentally different strategi...

journal_title：Cell

authors： Wahl MC,Will CL,Lührmann R

更新日期：2009-02-20 00:00:00

abstract：:Misfolded proteins of the ER are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded luminal protein domain across a lipid bila...

journal_title：Cell

authors： Baldridge RD,Rapoport TA

更新日期：2016-07-14 00:00:00

abstract：:We have identified a novel octamer binding factor (Oct-3) in P19 embryonal carcinoma cells. Oct-3, which recognizes the typical octamer motif (ATTTGCAT) as well as the AT-rich sequence TTAAAATTCA, is present in P19 stem cells but disappears when the cells are induced to differentiate by retinoic acid (RA). Cloned cDNA...

journal_title：Cell

authors： Okamoto K,Okazawa H,Okuda A,Sakai M,Muramatsu M,Hamada H

更新日期：1990-02-09 00:00:00

abstract：:A long-standing question in the study of long-term memory is how a memory trace persists for years when the proteins that initiated the process turn over and disappear within days. Previously, we postulated that self-sustaining amyloidogenic oligomers of cytoplasmic polyadenylation element-binding protein (CPEB) provi...

journal_title：Cell

authors： Majumdar A,Cesario WC,White-Grindley E,Jiang H,Ren F,Khan MR,Li L,Choi EM,Kannan K,Guo F,Unruh J,Slaughter B,Si K

更新日期：2012-02-03 00:00:00

abstract：:Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chr...

journal_title：Cell

authors： Voit RA,Sankaran VG

更新日期：2020-01-09 00:00:00

abstract：:Newly synthesized proteins are believed to move from the endoplasmic reticulum (ER) to the Golgi by bulk flow, and sorting is assumed to occur exclusively in the trans-Golgi network (TGN). Using quantitative immunoelectron microscopy, we demonstrate that vesicular stomatitis virus glycoprotein (VSV-G) is sorted from r...

journal_title：Cell

authors： Balch WE,McCaffery JM,Plutner H,Farquhar MG

更新日期：1994-03-11 00:00:00

abstract：:Activation of the transcription factor NF-kappaB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-kappaB-inducing kinase (NIK). In a yeast two-hybrid screen for NIK-interacting proteins, we have identified a protein kinase previously known as CHUK. Overexpression of CHUK activates a NF-kappaB-de...

journal_title：Cell

authors： Régnier CH,Song HY,Gao X,Goeddel DV,Cao Z,Rothe M

更新日期：1997-07-25 00:00:00

abstract：:This year, the Lasker Foundation confers its Clinical Medical Research Award on Akira Endo for his isolation from fungi of statins, potent inhibitors of cholesterol synthesis in the liver. The introduction of statins to clinical practice has markedly reduced morbidity and mortality from atherosclerotic cardiovascular ...

journal_title：Cell

authors： Stossel TP

更新日期：2008-09-19 00:00:00

abstract：:DNA repair is an essential process for preserving genome integrity in all organisms. In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into centers (foci). Here, we analyze the cellular response to DNA double-strand breaks (DSBs) and replication stress in Saccharomyces...

journal_title：Cell

authors： Lisby M,Barlow JH,Burgess RC,Rothstein R

更新日期：2004-09-17 00:00:00

abstract：:We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...

journal_title：Cell

authors： Kasthuri N,Hayworth KJ,Berger DR,Schalek RL,Conchello JA,Knowles-Barley S,Lee D,Vázquez-Reina A,Kaynig V,Jones TR,Roberts M,Morgan JL,Tapia JC,Seung HS,Roncal WG,Vogelstein JT,Burns R,Sussman DL,Priebe CE,Pfister H

更新日期：2015-07-30 00:00:00

abstract：:Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation...

journal_title：Cell

authors： Beelman CA,Parker R

更新日期：1995-04-21 00:00:00

abstract：:Poly(A)-containing RNA, isolated from rat ventral prostate, has been analyzed for its base sequence complexity. The kinetics of hybridization of total cellular poly(A)-containing RNA with its complementary DNA (cDNA) from normal and castrated animals are markedly different. RNA from normal animals consists of three ab...

journal_title：Cell

authors： Parker MG,Mainwaring WI

更新日期：1977-10-01 00:00:00

abstract：:Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential increase in PTM identification. However, the functional significance of the vast majority of these modifications remains unknown. To address this problem, we compiled ...

journal_title：Cell

authors： Beltrao P,Albanèse V,Kenner LR,Swaney DL,Burlingame A,Villén J,Lim WA,Fraser JS,Frydman J,Krogan NJ

更新日期：2012-07-20 00:00:00

abstract：:To understand the role of FoxO family members in hematopoiesis, we conditionally deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited myeloid lineage expansion, lymphoid developmental abnormalities, and a marked decrease of the lineage-negative Sca-1+, c-Kit+ (LSK) compartme...

journal_title：Cell

authors： Tothova Z,Kollipara R,Huntly BJ,Lee BH,Castrillon DH,Cullen DE,McDowell EP,Lazo-Kallanian S,Williams IR,Sears C,Armstrong SA,Passegué E,DePinho RA,Gilliland DG

更新日期：2007-01-26 00:00:00

abstract：:Specific active transcription units on chromosome IV in the salivary glands of Chironomus tentans have been visualized by the Miller spreading technique and in situ by conventional electron microscopy. These units are likely to be located in the two most conspicuous puffs on chromosome IV, Balbiani ring 1 (BR 1) and B...

journal_title：Cell

authors： Lamb MM,Daneholt B

更新日期：1979-08-01 00:00:00

abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...

journal_title：Cell

authors： Ioannou MS,Jackson J,Sheu SH,Chang CL,Weigel AV,Liu H,Pasolli HA,Xu CS,Pang S,Matthies D,Hess HF,Lippincott-Schwartz J,Liu Z

更新日期：2019-05-30 00:00:00

abstract：:The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails the association of beta-catenin with nuclear TCF/LEF proteins and results in transcriptional activation of target genes. The mechanism by which nuclear beta-catenin controls transcription is largely unknown. Here we genetically...

journal_title：Cell

authors： Mosimann C,Hausmann G,Basler K

更新日期：2006-04-21 00:00:00

abstract：:Characteristic of chronic myelogenous leukemia (CML) is the presence of the chimeric p210(bcr-abl) protein possessing elevated protein tyrosine kinase activity relative to normal c-abl tyrosine kinase. Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine-phosphory...

journal_title：Cell

authors： Carpino N,Wisniewski D,Strife A,Marshak D,Kobayashi R,Stillman B,Clarkson B

更新日期：1997-01-24 00:00:00

abstract：:In budding yeast, septins are involved in the morphogenesis checkpoint and the DNA damage checkpoint, both of which regulate cell-cycle progression. In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK....

journal_title：Cell

authors： Kinoshita M,Takeda S

更新日期：2007-09-07 00:00:00

abstract：:The major site of in vivo transcriptional initiation for both heavy and light strands of human mitochondrial DNA is the displacement-loop region. Transcripts synthesized in vitro by human mitochondrial RNA polymerase were mapped to the nucleotide level and have identical 5' end map positions to those reported for in v...

journal_title：Cell

authors： Chang DD,Clayton DA

更新日期：1984-03-01 00:00:00

abstract：:Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell su...

journal_title：Cell

authors： Lu Y,Zhao Q,Liao JY,Song E,Xia Q,Pan J,Li Y,Li J,Zhou B,Ye Y,Di C,Yu S,Zeng Y,Su S

更新日期：2020-03-19 00:00:00

abstract：:The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be...

journal_title：Cell

authors： Ogata K,Morikawa S,Nakamura H,Sekikawa A,Inoue T,Kanai H,Sarai A,Ishii S,Nishimura Y

更新日期：1994-11-18 00:00:00

abstract：:Voluntary movement is a result of signals transmitted through a communication channel that links the internal world in our minds to the physical world around us. Intention can be considered the desire to effect change on our environment, and this is contained in the signals from the brain, passed through the nervous s...

journal_title：Cell

authors： Schwartz AB

更新日期：2016-03-10 00:00:00