Abstract:
:Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chronic kidney disease (CKD).
journal_name
Celljournal_title
Cellauthors
Voit RA,Sankaran VGdoi
10.1016/j.cell.2019.12.010subject
Has Abstractpub_date
2020-01-09 00:00:00pages
6issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(19)31372-8journal_volume
180pub_type
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