Abstract:
:During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very similar to that of the wild-type MS blastomere. In pie-1 mutants one additional posterior blastomere adopts an MS-like fate, and in mex-1 mutants four additional anterior blastomeres adopt an MS-like fate. We propose that maternally provided pie-1(+) and mex-1(+) gene products may function in the early embryo to localize or regulate factors that determine the fate of the MS blastomere.
journal_name
Celljournal_title
Cellauthors
Mello CC,Draper BW,Krause M,Weintraub H,Priess JRdoi
10.1016/0092-8674(92)90542-ksubject
Has Abstractpub_date
1992-07-10 00:00:00pages
163-76issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(92)90542-Kjournal_volume
70pub_type
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