Abstract:
:Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how information is encoded and transmitted through this circuit, we performed electrophysiological recordings in mice observing a demonstrator mouse undergo associative fear conditioning and found that BLA-projecting ACC (ACC→BLA) neurons preferentially encode socially derived aversive cue information. Inhibition of ACC→BLA alters real-time amygdala representation of the aversive cue during observational conditioning. Selective inhibition of the ACC→BLA projection impaired acquisition, but not expression, of observational fear conditioning. We show that information derived from observation about the aversive value of the cue is transmitted from the ACC to the BLA and that this routing of information is critically instructive for observational fear conditioning. VIDEO ABSTRACT.
journal_name
Celljournal_title
Cellauthors
Allsop SA,Wichmann R,Mills F,Burgos-Robles A,Chang CJ,Felix-Ortiz AC,Vienne A,Beyeler A,Izadmehr EM,Glober G,Cum MI,Stergiadou J,Anandalingam KK,Farris K,Namburi P,Leppla CA,Weddington JC,Nieh EH,Smith AC,Ba D,Brodoi
10.1016/j.cell.2018.04.004subject
Has Abstractpub_date
2018-05-31 00:00:00pages
1329-1342.e18issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(18)30457-4journal_volume
173pub_type
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