Abstract：
:Mucus production by goblet cells of the large intestine serves as a crucial antimicrobial protective mechanism at the interface between the eukaryotic and prokaryotic cells of the mammalian intestinal ecosystem. However, the regulatory pathways involved in goblet cell-induced mucus secretion remain largely unknown. Here, we demonstrate that the NLRP6 inflammasome, a recently described regulator of colonic microbiota composition and biogeographical distribution, is a critical orchestrator of goblet cell mucin granule exocytosis. NLRP6 deficiency leads to defective autophagy in goblet cells and abrogated mucus secretion into the large intestinal lumen. Consequently, NLRP6 inflammasome-deficient mice are unable to clear enteric pathogens from the mucosal surface, rendering them highly susceptible to persistent infection. This study identifies an innate immune regulatory pathway governing goblet cell mucus secretion, linking nonhematopoietic inflammasome signaling to autophagy and highlighting the goblet cell as a critical innate immune player in the control of intestinal host-microbial mutualism. PAPERCLIP:
journal_name
Celljournal_title
Cellauthors
Wlodarska M,Thaiss CA,Nowarski R,Henao-Mejia J,Zhang JP,Brown EM,Frankel G,Levy M,Katz MN,Philbrick WM,Elinav E,Finlay BB,Flavell RAdoi
10.1016/j.cell.2014.01.026subject
Has Abstractpub_date
2014-02-27 00:00:00pages
1045-59issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(14)00078-6journal_volume
156pub_type
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