Abstract：
:Viable yet damaged cells can accumulate during development and aging. Although eliminating those cells may benefit organ function, identification of this less fit cell population remains challenging. Previously, we identified a molecular mechanism, based on "fitness fingerprints" displayed on cell membranes, which allows direct fitness comparison among cells in Drosophila. Here, we study the physiological consequences of efficient cell selection for the whole organism. We find that fitness-based cell culling is naturally used to maintain tissue health, delay aging, and extend lifespan in Drosophila. We identify a gene, azot, which ensures the elimination of less fit cells. Lack of azot increases morphological malformations and susceptibility to random mutations and accelerates tissue degeneration. On the contrary, improving the efficiency of cell selection is beneficial for tissue health and extends lifespan.
journal_name
Celljournal_title
Cellauthors
Merino MM,Rhiner C,Lopez-Gay JM,Buechel D,Hauert B,Moreno Edoi
10.1016/j.cell.2014.12.017subject
Has Abstractpub_date
2015-01-29 00:00:00pages
461-76issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(14)01587-6journal_volume
160pub_type
杂志文章相关文献
CELL文献大全abstract：:Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.04.018
更新日期：2016-05-19 00:00:00
abstract：:Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1 persisting, IgG3 r...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.04.036
更新日期：2019-05-30 00:00:00
abstract：:The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2018.05.023
更新日期：2018-05-31 00:00:00
abstract：:Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at...
journal_title：Cell
pub_type： 杂志文章,收录出版
doi：10.1016/s0092-8674(02)01037-1
更新日期：2002-10-18 00:00:00
abstract：:How cells generate a single axis of polarity for mating, division, and movement is unknown. In this issue, Howell et al. (2009) use a synthetic biology approach to demonstrate that rapid competition for a soluble signaling component (Bem1) is essential to ensure a unique axis of polarity in budding yeast. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.10.028
更新日期：2009-11-13 00:00:00
abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.07.015
更新日期：2019-08-08 00:00:00
abstract：:The S. cerevisiae CLN genes encode cyclin homologs essential for progression from G1 to S phase. The CLN2 gene encodes a 62 kd polypeptide that accumulates periodically, peaking during G1 and decreasing rapidly thereafter, and is rapidly lost following exposure of cells to mating pheromone. Cln2 abundance can be expla...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90361-h
更新日期：1990-07-27 00:00:00
abstract：:At anaphase onset, the protease separase triggers chromosome segregation by cleaving the chromosomal cohesin complex. Here, we show that cohesin destruction in metaphase is sufficient for segregation of much of the budding yeast genome, but not of the long arm of chromosome XII that contains the rDNA repeats. rDNA in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(04)00415-5
更新日期：2004-05-14 00:00:00
abstract：:Microglia are the resident macrophages of the CNS, and their functions have been extensively studied in various brain pathologies. The physiological roles of microglia in brain plasticity and function, however, remain unclear. To address this question, we generated CX3CR1(CreER) mice expressing tamoxifen-inducible Cre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.11.030
更新日期：2013-12-19 00:00:00
abstract：:Viral infection causes the host to activate an antiviral response that, in part, is dependent on mitochondrial antiviral signaling protein (MAVS) to stimulate type I interferons. Zhang et al. (2019) demonstrate that glucose-generated lactate interacts with MAVS to suppress type I interferons. This study links glucose ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2019.05.057
更新日期：2019-06-27 00:00:00
abstract：:Neurons make networks of intercellular connections. Many other cells also send out long cellular extensions and "touch" other cells far away. The extensions are intriguing, but what do they do? Possible rationales for this cell behavior include: (1) forming precise binary connections with the possibility of forming mo...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(03)00156-9
更新日期：2003-03-07 00:00:00
abstract：:The enteric bacteria Salmonella typhimurium has the ability to invade (enter) nonphagocytic cells. The internalization process occurs as a result of an intimate interaction between the bacteria and the host cell, in which S. typhimurium triggers a cascade of host cell-signaling events leading to the formation of host ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90510-x
更新日期：1994-02-25 00:00:00
abstract：:Xenopus laevis oocytes were used as a model system to study the intracellular fate of proteins incorporated by endocytosis. We found that the intracellular stability and compartmentation of proteins incorporated by receptor-mediated endocytosis differed substantially from that of proteins incorporated by nonspecific e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90153-1
更新日期：1980-11-01 00:00:00
abstract：:We have cloned and characterized the rat telomerase protein component 1 gene (TLP1), which is related to the gene for Tetrahymena p80. The cDNA encodes a 2629 amino acid sequence and produces the TLP1 proteins p240 and p230. The anti-TLP1 antibody specifically immunoprecipitated the telomerase activity. Moreover, p240...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81933-9
更新日期：1997-03-21 00:00:00
abstract：:Acquisition of the ability to produce and respond to a growth factor may result in increased cellular proliferation and could lead to malignant transformation. The fact that a large variety of tumor cells secrete transforming growth factor-alpha (TGF-alpha) suggests involvement of TGF-alpha in cellular transformation ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90747-6
更新日期：1986-07-18 00:00:00
abstract：:The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype includes severe craniofac...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81732-8
更新日期：1998-09-18 00:00:00
abstract：:The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00262-8
更新日期：2001-03-09 00:00:00
abstract：:The removal of apoptotic cells by phagocytic neighbors is essential for metazoan development but remains poorly characterized. Here we report the discovery of a Drosophila phagocytosis receptor, Six-microns-under (SIMU), which is expressed in highly phagocytic cell types during development and required for efficient a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.02.052
更新日期：2008-05-02 00:00:00
abstract：:While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the a...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2009.04.037
更新日期：2009-05-01 00:00:00
abstract：:Three membrane microdomains can be identified on docked vacuoles: "outside" membrane, not in contact with other vacuoles, "boundary" membrane that contacts adjacent vacuoles, and "vertices," where boundary and outside membrane meet. In living cells and in vitro, vacuole fusion occurs at vertices rather than from a cen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00632-3
更新日期：2002-02-08 00:00:00
abstract：:We have shown that covalent conjugation of ubiquitin to proteins is temperature-sensitive in the mouse cell cycle mutant ts85 due to a specifically thermolabile ubiquitin-activating enzyme (accompanying paper). We show here that degradation of short-lived proteins is also temperature sensitive in ts85 , in contrast to...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90300-3
更新日期：1984-05-01 00:00:00
abstract：:Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of innate susceptibility to Mycobacterium marinum. A ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.02.013
更新日期：2010-03-05 00:00:00
abstract：:Voluntary movement is a result of signals transmitted through a communication channel that links the internal world in our minds to the physical world around us. Intention can be considered the desire to effect change on our environment, and this is contained in the signals from the brain, passed through the nervous s...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.02.038
更新日期：2016-03-10 00:00:00
abstract：:ATRX is an X-linked gene of the SWI/SNF family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression. Here we show that ATRX binds to tandem repeat (TR) sequences in both telomeres and euchromatin. Genes associated with these TRs can be dysregulated when ATRX is mutated, and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.09.023
更新日期：2010-10-29 00:00:00
abstract：:When human lymphoblastoid mRNA was microinjected into X. laevis oocytes, titers of interferon rapidly reached a maximum inside the oocyte while accumulation of interferon continued in the incubation medium for at least 45 hr. If interferon protein was injected into oocytes it was rapidly inactivated. Significantly, ne...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90260-5
更新日期：1979-07-01 00:00:00
abstract：:Sucrose gradient analysis of DNA isolated from detergent-pronase lysates of adult flies has been used to look for ribosomal genes not integrated into the DNA of the chromosome in genotypes containing various combinations of inversions having breakpoints in the proximal heterochromatin of the X chromosome. Unintegrated...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90056-3
更新日期：1977-06-01 00:00:00
abstract：:The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the maintenance of genome stability. We have identified a p53-inducible gene named TIGAR (TP53-induced glycolysis and apoptosis regulator). TIGAR expression lowered fruc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.05.036
更新日期：2006-07-14 00:00:00
abstract：:Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the CO...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.03.006
更新日期：2012-03-30 00:00:00
abstract：:Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.04.008
更新日期：2017-05-04 00:00:00
abstract：:Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the prot...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90538-7
更新日期：1988-01-15 00:00:00
