Abstract：
:Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) and lymph nodes (LN) of infected rhesus monkeys for weeks after virus has been cleared from peripheral blood, urine, and mucosal secretions. ZIKV-specific neutralizing antibodies correlated with rapid clearance of virus in peripheral blood but remained undetectable in CSF for the duration of the study. Viral persistence in both CSF and LN correlated with upregulation of mechanistic target of rapamycin (mTOR), proinflammatory, and anti-apoptotic signaling pathways, as well as downregulation of extracellular matrix signaling pathways. These data raise the possibility that persistent or occult neurologic and lymphoid disease may occur following clearance of peripheral virus in ZIKV-infected individuals.
journal_name
Celljournal_title
Cellauthors
Aid M,Abbink P,Larocca RA,Boyd M,Nityanandam R,Nanayakkara O,Martinot AJ,Moseley ET,Blass E,Borducchi EN,Chandrashekar A,Brinkman AL,Molloy K,Jetton D,Tartaglia LJ,Liu J,Best K,Perelson AS,De La Barrera RA,Lewis MGdoi
10.1016/j.cell.2017.04.008subject
Has Abstractpub_date
2017-05-04 00:00:00pages
610-620.e14issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(17)30421-Xjournal_volume
169pub_type
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