Abstract：
:The copy number of yeast histone genes was increased by inserting an extra H2A,H2B gene pair into the haploid genome by the technique of yeast transformation. The presence of this extra gene copy has no detectable effect on cell growth. The steady-state levels of histone H2A,H2B mRNAs are not elevated in transformed strains, and they correspond to the levels measured for the parental strain. The transcription rate is increased in these strains, however, and the parental steady-state levels of histone mRNAs are maintained by increased turnover of histone transcripts. These results demonstrate that yeast histone genes display dosage compensation through the operation of posttranscriptional controls. They also suggest that maintainance of a constant ratio between histone mRNA concentration and the rate of chromosome replication may be of general importance to histone mRNA metabolism.
journal_name
Celljournal_title
Cellauthors
Osley MA,Hereford LMdoi
10.1016/0092-8674(81)90327-5subject
Has Abstractpub_date
1981-05-01 00:00:00pages
377-84issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(81)90327-5journal_volume
24pub_type
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