Nucleotide sequence of salmon testes and salmon liver cytoplasmic initiator tRNA.

abstract：:The initiation of transcription from the nitrogen-regulated promoter glnAp2 requires RNA polymerase containing sigma 54, the transcriptional activator NRI, and the protein kinase NRII, responsible for the conversion of NRI to the active NRI-phosphate. NRI-phosphate does not increase the ability of sigma 54-containing ...

journal_title：Cell

authors： Ninfa AJ,Reitzer LJ,Magasanik B

更新日期：1987-09-25 00:00:00

abstract：:VopL is an effector protein from Vibrio parahaemolyticus that nucleates actin filaments. VopL consists of a VopL C-terminal domain (VCD) and an array of three WASP homology 2 (WH2) motifs. Here, we report the crystal structure of the VCD dimer bound to actin. The VCD organizes three actin monomers in a spatial arrange...

journal_title：Cell

authors： Zahm JA,Padrick SB,Chen Z,Pak CW,Yunus AA,Henry L,Tomchick DR,Chen Z,Rosen MK

更新日期：2013-10-10 00:00:00

abstract：:Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, binds to two receptor tyrosine kinases, KDR/Flk-1 and Flt-1. We now describe the purification and the expression cloning from tumor cells of a third VEGF receptor, one that binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (...

journal_title：Cell

authors： Soker S,Takashima S,Miao HQ,Neufeld G,Klagsbrun M

更新日期：1998-03-20 00:00:00

abstract：:Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...

journal_title：Cell

authors： Ohtsubo K,Takamatsu S,Minowa MT,Yoshida A,Takeuchi M,Marth JD

更新日期：2005-12-29 00:00:00

abstract：:Fragile X syndrome results from the expansion of a CGG repeat that is normally interrupted by occasional AGG triplets. Linkage disequilibrium suggests that certain normal haplotypes may contribute unequally to the pool of fragile X chromosomes. Sequence analysis of normal alleles demonstrates haplotype-specific variat...

journal_title：Cell

authors： Kunst CB,Warren ST

更新日期：1994-06-17 00:00:00

abstract：:Goosecoid (gsc), a homeobox gene expressed specifically in the dorsal blastopore lip of the Xenopus gastrula, is considered to play an important role in Spemann's organizer phenomenon. Lineage tracing and time-lapse microscopy were used to follow the fate of embryonic cells microinjected with gsc mRNA. Microinjected g...

journal_title：Cell

authors： Niehrs C,Keller R,Cho KW,De Robertis EM

更新日期：1993-02-26 00:00:00

abstract：:Inducer T-cell clones reactive to the p-azobenzenearsonate (arsonate) hapten possess binding sites for radioactive arsanylated proteins, which are not present on clones with other antigen specificities. Binding occurred in the absence of histocompatibility proteins. Binding was specific for the p-azobenzenearsonate ha...

journal_title：Cell

authors： Rao A,Ko WW,Faas SJ,Cantor H

更新日期：1984-04-01 00:00:00

abstract：:Sec7-related guanine nucleotide exchange factors (GEFs) initiate vesicle budding from the Golgi membrane surface by converting the GTPase ARF to a GTP-bound, membrane-associated form. Here we report the crystal structure of the catalytic Sec7 homology domain of Arno, a human GEF for ARF1, determined at 2.2 angstroms r...

journal_title：Cell

authors： Mossessova E,Gulbis JM,Goldberg J

更新日期：1998-02-06 00:00:00

abstract：:The S. cerevisiae gene MCR1 encodes two mitochondrial isoforms of NADH-cytochrome b5 reductase. The primary translation product has an amino-terminal matrix-targeting signal, followed by a stretch of 21 uncharged amino acids. This precursor protein is inserted into the outer membrane, but only about one-third of the m...

journal_title：Cell

authors： Hahne K,Haucke V,Ramage L,Schatz G

更新日期：1994-12-02 00:00:00

abstract：:Recent evidence suggests that a subset of cancer cells within some tumors, the so-called cancer stem cells, may drive the growth and metastasis of these tumors. Understanding the pathways that regulate proliferation, self-renewal, survival, and differentiation of malignant and normal stem cells may shed light on mecha...

journal_title：Cell

authors： Clarke MF,Fuller M

更新日期：2006-03-24 00:00:00

abstract：:Post-translational modification of tubulin offers a mechanism for functional diversification of microtubules and regulation in a variety of physiological contexts. This SnapShot recaps the current state of understanding of tubulin posttranslational modifications and their functions in the regulation of biological proc...

journal_title：Cell

authors： Magiera MM,Singh P,Janke C

更新日期：2018-05-31 00:00:00

abstract：:Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive c...

journal_title：Cell

authors： Jakob U,Muse W,Eser M,Bardwell JC

更新日期：1999-02-05 00:00:00

abstract：:The archetypal human tumor suppressor p53 is considered to have unique transactivation properties. The assumption is based on the fact that additionally identified human p53 isoforms lack transcriptional activity. However, we provide evidence for the existence of an alternatively spliced p53 isoform (Deltap53) that ex...

journal_title：Cell

authors： Rohaly G,Chemnitz J,Dehde S,Nunez AM,Heukeshoven J,Deppert W,Dornreiter I

更新日期：2005-07-15 00:00:00

abstract：:Prions, self-propagating protein structures that can be transmitted between cells and different organisms, usually consist of ordered protein aggregates. Alberti et al. (2009) now present a systematic approach for the discovery of new prions that expands the spectrum of their biological functions. ...

journal_title：Cell

authors： Fowler DM,Kelly JW

更新日期：2009-04-03 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and va...

journal_title：Cell

authors： Oberfeld B,Achanta A,Carpenter K,Chen P,Gilette NM,Langat P,Said JT,Schiff AE,Zhou AS,Barczak AK,Pillai S

更新日期：2020-05-14 00:00:00

abstract：:TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show ...

journal_title：Cell

authors： Demetriades C,Doumpas N,Teleman AA

更新日期：2014-02-13 00:00:00

abstract：:Accumulating evidence for nascent-peptide-mediated regulation of translation suggests that all nascent peptides do not necessarily interact with the ribosome in a similar manner. Recent studies have helped to elucidate the exit route of the nascent chain and its interactions with the ribosome. ...

journal_title：Cell

authors： Tenson T,Ehrenberg M

更新日期：2002-03-08 00:00:00

abstract：:The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be...

journal_title：Cell

authors： Ogata K,Morikawa S,Nakamura H,Sekikawa A,Inoue T,Kanai H,Sarai A,Ishii S,Nishimura Y

更新日期：1994-11-18 00:00:00

abstract：:We previously demonstrated that pseudogenes complementary to the small nuclear RNAs U1, U2 and U3 are dispersed and abundant in the human genome. Here we report that three pseudogenes (U1.101, U2.13 and U3.5) are flanked by perfect short direct repeats of 16 to 19 base pairs. In all three pseudogenes. the upstream dir...

journal_title：Cell

authors： Van Arsdell SW,Denison RA,Bernstein LB,Weiner AM,Manser T,Gesteland RF

更新日期：1981-10-01 00:00:00

abstract：:The structure of chicken erythrocyte and chicken liver chromatin has been studied by enzymatic digestion with micrococcal nuclease and DNAase I. Comparison of the fragments produced by brief digestion with micrococcal nuclease indicates that chicken erythrocyte chromatin has a longer nucleosome repeat than chicken liv...

journal_title：Cell

authors： Morris NR

更新日期：1976-12-01 00:00:00

abstract：:Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA. ...

journal_title：Cell

authors： Friedberg EC,Fischhaber PL,Kisker C

更新日期：2001-10-05 00:00:00

abstract：:Despite the obvious importance of epithelial stem cells in tissue homeostasis and tumorigenesis, little is known about their specific location or biological characteristics. Using 3H-thymidine labeling, we have identified a subpopulation of corneal epithelial basal cells, located in the peripheral cornea in a region c...

journal_title：Cell

authors： Cotsarelis G,Cheng SZ,Dong G,Sun TT,Lavker RM

更新日期：1989-04-21 00:00:00

abstract：:During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (POUT) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable conformation (PIN) that arr...

journal_title：Cell

authors： Hussain T,Llácer JL,Fernández IS,Munoz A,Martin-Marcos P,Savva CG,Lorsch JR,Hinnebusch AG,Ramakrishnan V

更新日期：2014-10-23 00:00:00

abstract：:We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unch...

journal_title：Cell

authors： Jinks-Robertson S,Gourse RL,Nomura M

更新日期：1983-07-01 00:00:00

abstract：:Ras-related GTPases are positively regulated by guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP. The crystal structure of the Sec7 domain GEF bound to nucleotide-free ARF1 GTPase has been determined at 2.8 A resolution and the structure of ARF1 in the GTP-analog form determined at 1...

journal_title：Cell

authors： Goldberg J

更新日期：1998-10-16 00:00:00

abstract：:Targeting of the RAS pathway has long been a critical therapeutic challenge in oncology. Burgess et al. examine how the relative expression of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a model of KrasG12D mutant acute myeloid leukemia and propose its use as a predictive bi...

journal_title：Cell

authors： Tothova Z,Ebert BL

更新日期：2017-02-23 00:00:00

abstract：:22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A(+/-) mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain microRNAs. Here, we show a drastic reduction of miR-185, which resides within...

journal_title：Cell

authors： Xu B,Hsu PK,Stark KL,Karayiorgou M,Gogos JA

更新日期：2013-01-17 00:00:00

abstract：:Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin kappa chain enhancer. Both cDNAs share a region of extensive identity to the Drosophila daughterless gene and obvious similarity to a segment in three myc proteins, MyoD, and members of the Dro...

journal_title：Cell

authors： Murre C,McCaw PS,Baltimore D

更新日期：1989-03-10 00:00:00

abstract：:Cholera toxin is assembled from two subunits in the periplasm of Vibrio cholerae and disassembled in the analogous compartment of target cells, the lumen of the endoplasmic reticulum (ER), before a fragment of it, the A1 chain, is transported into the cytosol. We show that protein disulfide isomerase (PDI) in the ER l...

journal_title：Cell

authors： Tsai B,Rodighiero C,Lencer WI,Rapoport TA

更新日期：2001-03-23 00:00:00

abstract：:The HIV-1 trans-activator Tat increases levels of viral gene expression and replication. The target for Tat is an RNA stem-loop called TAR, located at the 5' end of all viral transcripts. To study the mechanism of action and map functional domains of Tat, we fused Tat to the coat protein of bacteriophage MS2, an RNA b...

journal_title：Cell

authors： Selby MJ,Peterlin BM

更新日期：1990-08-24 00:00:00