Abstract：
:The S. cerevisiae gene MCR1 encodes two mitochondrial isoforms of NADH-cytochrome b5 reductase. The primary translation product has an amino-terminal matrix-targeting signal, followed by a stretch of 21 uncharged amino acids. This precursor protein is inserted into the outer membrane, but only about one-third of the molecules become firmly anchored to the outer face of that membrane. The remaining molecules pass through the outer membrane into the inner membrane, are cleaved by inner membrane protease 1, and are released into the intermembrane space. Incomplete translocation arrest in the outer membrane is a novel mechanism by which the product of a single gene is sorted into different compartments of the same organelle.
journal_name
Celljournal_title
Cellauthors
Hahne K,Haucke V,Ramage L,Schatz Gdoi
10.1016/0092-8674(94)90072-8subject
Has Abstractpub_date
1994-12-02 00:00:00pages
829-39issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(94)90072-8journal_volume
79pub_type
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