Transcription initiation at its most basic level.

abstract：:Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like protein containing intrinsically disordered domains associated with the neurodegenerative disease ALS. We show that, in cells, FUS forms liqui...

journal_title：Cell

authors： Patel A,Lee HO,Jawerth L,Maharana S,Jahnel M,Hein MY,Stoynov S,Mahamid J,Saha S,Franzmann TM,Pozniakovski A,Poser I,Maghelli N,Royer LA,Weigert M,Myers EW,Grill S,Drechsel D,Hyman AA,Alberti S

更新日期：2015-08-27 00:00:00

abstract：:The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in nondividing cells such as macrophages. A critical regulator of this process is the C-terminal tyrosine phosphorylation of MA during virus maturation. Here, we reveal the mechanism of this phenomenon, by demonstrating that tyrosine...

journal_title：Cell

authors： Gallay P,Swingler S,Song J,Bushman F,Trono D

更新日期：1995-11-17 00:00:00

abstract：:Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birt...

journal_title：Cell

authors： Cox LM,Yamanishi S,Sohn J,Alekseyenko AV,Leung JM,Cho I,Kim SG,Li H,Gao Z,Mahana D,Zárate Rodriguez JG,Rogers AB,Robine N,Loke P,Blaser MJ

更新日期：2014-08-14 00:00:00

abstract：:NRK fibroblasts exposed to transforming growth factor-beta (TGF-beta) show increased binding of radiolabeled epidermal growth factor (EGF) relative to untreated cells. The binding of another growth factor, rat insulin-like growth factor-II, is unaffected. The increase in EGF binding induced by TGF-beta is not due to i...

journal_title：Cell

authors： Assoian RK,Frolik CA,Roberts AB,Miller DM,Sporn MB

更新日期：1984-01-01 00:00:00

abstract：:The S. cerevisiae CLN genes encode cyclin homologs essential for progression from G1 to S phase. The CLN2 gene encodes a 62 kd polypeptide that accumulates periodically, peaking during G1 and decreasing rapidly thereafter, and is rapidly lost following exposure of cells to mating pheromone. Cln2 abundance can be expla...

journal_title：Cell

authors： Wittenberg C,Sugimoto K,Reed SI

更新日期：1990-07-27 00:00:00

abstract：:Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond inde...

journal_title：Cell

authors： Welz PS,Zinna VM,Symeonidi A,Koronowski KB,Kinouchi K,Smith JG,Guillén IM,Castellanos A,Furrow S,Aragón F,Crainiciuc G,Prats N,Caballero JM,Hidalgo A,Sassone-Corsi P,Benitah SA

更新日期：2019-05-30 00:00:00

abstract：:The actin-filled stereocilia of cochlear hair cells deflect in response to sound by pivoting around rootlets at their insertion points at the sensory cell surface. Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots...

journal_title：Cell

authors： Boutet de Monvel J,Petit C

更新日期：2010-05-28 00:00:00

abstract：:The switch from membrane-bound to secreted-form IgM that occurs during differentiation of B lymphocytes has long been known to involve regulated processing of the heavy chain pre-mRNA. Here, we show that accumulation of one subunit of an essential polyadenylation factor (CstF-64) is specifically repressed in mouse pri...

journal_title：Cell

authors： Takagaki Y,Seipelt RL,Peterson ML,Manley JL

更新日期：1996-11-29 00:00:00

abstract：:A model of hematopoietic development wherein multipotentiality is conserved until segregation of myeloid and lymphoid potential has recently been challenged, proposing that megakaryocyte/erythrocyte (MegE) potential is lost in Flk2/Flt3-expressing early progenitors. Here, we used sensitive in vivo approaches to quanti...

journal_title：Cell

authors： Forsberg EC,Serwold T,Kogan S,Weissman IL,Passegué E

更新日期：2006-07-28 00:00:00

abstract：:Neural progenitors generate distinct cell types at different stages, but the mechanisms controlling these temporal transitions are poorly understood. In the Drosophila CNS, a cascade of transcription factors, the "temporal gene cascade," has been identified that acts to alter progenitor competence over time. However, ...

journal_title：Cell

authors： Baumgardt M,Karlsson D,Terriente J,Díaz-Benjumea FJ,Thor S

更新日期：2009-11-25 00:00:00

abstract：:The plant hormone auxin is central in patterning diverse plant tissues. The direction of auxin flow and the distribution of auxin within tissues are regulated by auxin efflux transporters that are polarly localized in cells. Feedback regulation between auxin and its transporters establishes homeostatic patterns of aux...

journal_title：Cell

authors： Leyser O

更新日期：2005-06-17 00:00:00

abstract：:The mouse t haplotypes show defects in spermatogenesis attributed to multiple loci on chromosome 17. We have cloned the gene for an abundant testicular germ cell protein, t complex polypeptide 1, which has a variant form in t haplotypes, TCP-1A. A cDNA clone, pB1.4, which hybridizes to a 19S mRNA that is abundant in h...

journal_title：Cell

authors： Willison KR,Dudley K,Potter J

更新日期：1986-03-14 00:00:00

abstract：:The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis. We report here that Swe1, the...

journal_title：Cell

authors： Harvey SL,Charlet A,Haas W,Gygi SP,Kellogg DR

更新日期：2005-08-12 00:00:00

abstract：:Receptor-mediated endocytosis of specific ligands is mediated through clustering of receptor-ligand complexes in coated pits on the cell surface. Following this clustering event, the ligand is internalized into a noncoated intracellular vesicle, the receptosome, which selectively avoids fusion with lysosomes and moves...

journal_title：Cell

authors： Willingham MC,Pastan I

更新日期：1980-08-01 00:00:00

abstract：:Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo. ME...

journal_title：Cell

authors： Liu S,Hausmann S,Carlson SM,Fuentes ME,Francis JW,Pillai R,Lofgren SM,Hulea L,Tandoc K,Lu J,Li A,Nguyen ND,Caporicci M,Kim MP,Maitra A,Wang H,Wistuba II,Porco JA Jr,Bassik MC,Elias JE,Song J,Topisirovic I,Van

更新日期：2019-01-24 00:00:00

abstract：:We have localized the regulatory sequence required for viral or poly(I)-poly(C) activation of human beta-interferon gene expression to a region located between -37 and -77 from the mRNA cap site. This sequence has the characteristics of an inducible enhancer element: it can act upstream or downstream of the beta-inter...

journal_title：Cell

authors： Goodbourn S,Zinn K,Maniatis T

更新日期：1985-06-01 00:00:00

abstract：:Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-asso...

journal_title：Cell

authors： Dustin ML

更新日期：2008-03-07 00:00:00

abstract：:Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mut...

journal_title：Cell

authors： Koh YH,Popova E,Thomas U,Griffith LC,Budnik V

更新日期：1999-08-06 00:00:00

abstract：:During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi. ...

journal_title：Cell

authors： Pellino JL,Sontheimer EJ

更新日期：2003-10-17 00:00:00

abstract：:This year marks the centenary of Robert Koch's Nobel Prize for discovering the cause of tuberculosis. Koch was also the first scientist to isolate the anthrax and cholera microbes. Yet perhaps one of his greatest contributions to biology is the least appreciated: his method for propagating individual colonies of bacte...

journal_title：Cell

authors： Weiss RA

更新日期：2005-11-18 00:00:00

abstract：:Infections disturb metabolic homeostasis in many contexts, but the underlying connections are not completely understood. To address this, we use paired genetic and computational screens in Drosophila to identify transcriptional regulators of immunity and pathology and their associated target genes and physiologies. We...

journal_title：Cell

authors： Clark RI,Tan SW,Péan CB,Roostalu U,Vivancos V,Bronda K,Pilátová M,Fu J,Walker DW,Berdeaux R,Geissmann F,Dionne MS

更新日期：2013-10-10 00:00:00

abstract：:The mipA gene of A. nidulans encodes a newly discovered member of the tubulin superfamily of proteins, gamma-tubulin. In A. nidulans, gamma-tubulin is essential for nuclear division and microtubule assembly and is associated with the spindle pole body, the fungal microtubule organizing center. By low stringency hybrid...

journal_title：Cell

authors： Zheng Y,Jung MK,Oakley BR

更新日期：1991-05-31 00:00:00

abstract：:Phage G1 gp67 is a 23 kDa protein that binds to the Staphylococcus aureus (Sau) RNA polymerase (RNAP) σ(A) subunit and blocks cell growth by inhibiting transcription. We show that gp67 has little to no effect on transcription from most promoters but is a potent inhibitor of ribosomal RNA transcription. A 2.0-Å-resolut...

journal_title：Cell

authors： Osmundson J,Montero-Diez C,Westblade LF,Hochschild A,Darst SA

更新日期：2012-11-21 00:00:00

abstract：:The yeast tropomyosin gene, designated TPM1, is present in a single copy per haploid genome and encodes a protein with a predicted molecular weight of 23.5 kd. The protein sequence is homologous to higher cell tropomyosins, including the characteristic hydrophobic-hydrophilic pseudoheptapeptide repeats. Indirect immun...

journal_title：Cell

authors： Liu HP,Bretscher A

更新日期：1989-04-21 00:00:00

abstract：:Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that cyclin A is undetectable in oocytes, appears within 15 min of fertilization, and is destroye...

journal_title：Cell

authors： Swenson KI,Farrell KM,Ruderman JV

更新日期：1986-12-26 00:00:00

abstract：:Epigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and f...

journal_title：Cell

authors： Calarco JP,Borges F,Donoghue MT,Van Ex F,Jullien PE,Lopes T,Gardner R,Berger F,Feijó JA,Becker JD,Martienssen RA

更新日期：2012-09-28 00:00:00

abstract：:The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activ...

journal_title：Cell

authors： Bar-Peled L,Kemper EK,Suciu RM,Vinogradova EV,Backus KM,Horning BD,Paul TA,Ichu TA,Svensson RU,Olucha J,Chang MW,Kok BP,Zhu Z,Ihle NT,Dix MM,Jiang P,Hayward MM,Saez E,Shaw RJ,Cravatt BF

更新日期：2017-10-19 00:00:00

abstract：:The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro. Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in ...

journal_title：Cell

authors： Gu W,Roeder RG

更新日期：1997-08-22 00:00:00

abstract：:The Clock mutation lengthens periodicity and reduces amplitude of circadian rhythms in mice. The effects of Clock are cell intrinsic and can be observed at the level of single neurons in the suprachiasmatic nucleus. To address how cells of contrasting genotype functionally interact in vivo to control circadian behavio...

journal_title：Cell

authors： Low-Zeddies SS,Takahashi JS

更新日期：2001-04-06 00:00:00

abstract：:The achaete-scute gene complex (AS-C), involved in differentiation of the sensory chaetes of D. melanogaster, and the yellow locus have been cloned. The yellow locus is the most distal and is followed, proximally, by the achaete and the scute loci. In the scute locus (75 kb), three transcription units separated by lon...

journal_title：Cell

authors： Campuzano S,Carramolino L,Cabrera CV,Ruíz-Gómez M,Villares R,Boronat A,Modolell J

更新日期：1985-02-01 00:00:00