Abstract：
:Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, the misregulation or loss of Notch signaling underlies a wide range of human disorders, from developmental syndromes to adult-onset diseases and cancer. Notch signaling is remarkably robust in most tissues even though each Notch molecule is irreversibly activated by proteolysis and signals only once without amplification by secondary messenger cascades. In this Review, we highlight recent studies in Notch signaling that reveal new molecular details about the regulation of ligand-mediated receptor activation, receptor proteolysis, and target selection.
journal_name
Celljournal_title
Cellauthors
Kopan R,Ilagan MXdoi
10.1016/j.cell.2009.03.045subject
Has Abstractpub_date
2009-04-17 00:00:00pages
216-33issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(09)00382-1journal_volume
137pub_type
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