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Glioma development: where did it all go wrong?

Abstract：

:Investigating the family tree of a tumor to identify its cellular origins is a daunting task. Liu et al. (2011) now use an elegant lineage tracing technique (MADM) to visualize glioma from its earliest stages. They show that mutations originally induced in neural stem cells lie dormant and only trigger malignant transformation following differentiation into oligodendrocyte precursor cells.

journal_name

Cell

journal_title

Cell

authors

Sukhdeo K,Hambardzumyan D,Rich JN

doi

10.1016/j.cell.2011.06.047

subject

Has Abstract

pub_date

2011-07-22 00:00:00

pages

187-8

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(11)00755-0

journal_volume

146

pub_type

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