Going Public in Support of Science.

Abstract:

:Scientists are stepping up like never before to support science in the public arena. In big and small ways, scientists are adopting creative ideas to promote science.

journal_name

Cell

journal_title

Cell

authors

Matheson S

doi

10.1016/j.cell.2017.03.029

subject

Has Abstract

pub_date

2017-04-06 00:00:00

pages

181-182

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(17)30348-3

journal_volume

169

pub_type

杂志文章

相关文献

CELL文献大全
  • Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin.

    abstract::The Polycomb group (Pc-G) proteins are responsible for keeping developmental regulators, like homeotic genes, stably and inheritably repressed during Drosophila development. Several similarities to a protein class involved in heterochromatin formation suggest that the Pc-G exerts its function at the higher order chrom...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(93)90328-n

    authors: Orlando V,Paro R

    更新日期:1993-12-17 00:00:00

  • 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region.

    abstract::We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81002-8

    authors: Leahy DJ,Aukhil I,Erickson HP

    更新日期:1996-01-12 00:00:00

  • Ferroptosis: an iron-dependent form of nonapoptotic cell death.

    abstract::Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells or be activated in specific pathological states. The oncogenic RAS-selective lethal small molecule erastin triggers a unique iron-dependent form of nonapoptotic cell death that we term ferroptosis. Ferroptosis is dependent up...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2012.03.042

    authors: Dixon SJ,Lemberg KM,Lamprecht MR,Skouta R,Zaitsev EM,Gleason CE,Patel DN,Bauer AJ,Cantley AM,Yang WS,Morrison B 3rd,Stockwell BR

    更新日期:2012-05-25 00:00:00

  • IKKalpha at the crossroads of inflammation and metastasis.

    abstract::The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. Th...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2007.03.029

    authors: Affara NI,Coussens LM

    更新日期:2007-04-06 00:00:00

  • Quantitative and dynamic assessment of the contribution of the ER to phagosome formation.

    abstract::Phagosomes were traditionally thought to originate from an invagination and scission of the plasma membrane to form a distinct intracellular vacuole. An alternative model implicating the endoplasmic reticulum (ER) as a major component of nascent and maturing phagosomes was recently proposed (Gagnon et al., 2002). To r...

    journal_title:Cell

    pub_type: 信件

    doi:10.1016/j.cell.2005.08.018

    authors: Touret N,Paroutis P,Terebiznik M,Harrison RE,Trombetta S,Pypaert M,Chow A,Jiang A,Shaw J,Yip C,Moore HP,van der Wel N,Houben D,Peters PJ,de Chastellier C,Mellman I,Grinstein S

    更新日期:2005-10-07 00:00:00

  • Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.

    abstract::Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vγ5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene express...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2016.08.030

    authors: Di Marco Barros R,Roberts NA,Dart RJ,Vantourout P,Jandke A,Nussbaumer O,Deban L,Cipolat S,Hart R,Iannitto ML,Laing A,Spencer-Dene B,East P,Gibbons D,Irving PM,Pereira P,Steinhoff U,Hayday A

    更新日期:2016-09-22 00:00:00

  • Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm.

    abstract::Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. In yeast, they also interact with active genes, attracting or retaining them at the nuclear periphery. In higher eukaryotes, some NPC components (nucleoporins) are also found in the nucleoplasm, with a so far unknown function. We have functio...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2010.01.011

    authors: Kalverda B,Pickersgill H,Shloma VV,Fornerod M

    更新日期:2010-02-05 00:00:00

  • The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

    abstract::NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans and that decreasing NAD(+) levels results in a further reduction in worm lifespan. Conversely, genetic or pharmacological...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.06.016

    authors: Mouchiroud L,Houtkooper RH,Moullan N,Katsyuba E,Ryu D,Cantó C,Mottis A,Jo YS,Viswanathan M,Schoonjans K,Guarente L,Auwerx J

    更新日期:2013-07-18 00:00:00

  • A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs.

    abstract::The alpha-amylase mRNAs which accumulate in two different tissues of the mouse, the salivary gland and the liver, are identical except for their 5' non-translated sequences: the 5' terminal 158 nucleotides of the major liver alpha-amylase mRNA are unrelated to the 5' terminal 47 nucleotides found in its salivary gland...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90140-9

    authors: Young RA,Hagenbüchle O,Schibler U

    更新日期:1981-02-01 00:00:00

  • Chemical genetics: where genetics and pharmacology meet.

    abstract::Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2007.01.021

    authors: Knight ZA,Shokat KM

    更新日期:2007-02-09 00:00:00

  • Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

    abstract::A cDNA clone encoding a novel hematopoietic growth factor activity produced by a gibbon T cell line has been identified using a mammalian cell expression cloning system. The sequence of this cDNA proved to have significant homology to the sequence encoding murine interleukin 3 (IL-3). The human gene, which was readily...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90360-0

    authors: Yang YC,Ciarletta AB,Temple PA,Chung MP,Kovacic S,Witek-Giannotti JS,Leary AC,Kriz R,Donahue RE,Wong GG

    更新日期:1986-10-10 00:00:00

  • Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of GDP and GTP.

    abstract::The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that the R201C mutation ca...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2018.03.018

    authors: Hu Q,Shokat KM

    更新日期:2018-05-17 00:00:00

  • Should you be tweeting?

    abstract::Twitter needs no introduction. This "microblogging" service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to some who have found value in tweeting. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2009.10.017

    authors: Bonetta L

    更新日期:2009-10-30 00:00:00

  • A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

    abstract::Oncogenic activation of RAS genes via point mutations occurs in 20%-30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a large number of effect...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2016.03.045

    authors: Athuluri-Divakar SK,Vasquez-Del Carpio R,Dutta K,Baker SJ,Cosenza SC,Basu I,Gupta YK,Reddy MV,Ueno L,Hart JR,Vogt PK,Mulholland D,Guha C,Aggarwal AK,Reddy EP

    更新日期:2016-04-21 00:00:00

  • Integration of Parallel Opposing Memories Underlies Memory Extinction.

    abstract::Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction of av...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2018.08.021

    authors: Felsenberg J,Jacob PF,Walker T,Barnstedt O,Edmondson-Stait AJ,Pleijzier MW,Otto N,Schlegel P,Sharifi N,Perisse E,Smith CS,Lauritzen JS,Costa M,Jefferis GSXE,Bock DD,Waddell S

    更新日期:2018-10-18 00:00:00

  • LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction.

    abstract::During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far slower reaction results ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(93)90645-7

    authors: Kim B,Little JW

    更新日期:1993-06-18 00:00:00

  • Mesenchymal to epithelial conversion in rat metanephros is induced by LIF.

    abstract::Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81524-x

    authors: Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

    更新日期:1999-11-12 00:00:00

  • The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice.

    abstract::Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice, this is because the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing V beta 3 and V beta 8.1, 8.2, and 8.3, and few oth...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(89)90980-x

    authors: White J,Herman A,Pullen AM,Kubo R,Kappler JW,Marrack P

    更新日期:1989-01-13 00:00:00

  • A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis.

    abstract::Pathogenic Vibrio cholerae remains a major human health concern. V. cholerae has a characteristic curved rod morphology, with a longer outer face and a shorter inner face. The mechanism and function of this curvature were previously unknown. Here, we identify and characterize CrvA, the first curvature determinant in V...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2016.12.019

    authors: Bartlett TM,Bratton BP,Duvshani A,Miguel A,Sheng Y,Martin NR,Nguyen JP,Persat A,Desmarais SM,VanNieuwenhze MS,Huang KC,Zhu J,Shaevitz JW,Gitai Z

    更新日期:2017-01-12 00:00:00

  • Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.

    abstract::Tyrosyl phosphorylation is implicated in the mechanism of insulin action. Mutation of the beta-subunit of the insulin receptor by substitution of tyrosyl residue 960 with phenylalanine had no effect on insulin-stimulated autophosphorylation or phosphotransferase activity of the purified receptor. However, unlike the n...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(88)80008-4

    authors: White MF,Livingston JN,Backer JM,Lauris V,Dull TJ,Ullrich A,Kahn CR

    更新日期:1988-08-26 00:00:00

  • Wnt Down, Tumors Wind Up?

    abstract::In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an e...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2015.06.008

    authors: Krimpenfort P,Berns A

    更新日期:2015-06-18 00:00:00

  • Transcription initiation at its most basic level.

    abstract::The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes. ...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/s0092-8674(03)00888-2

    authors: Marmorstein R

    更新日期:2003-11-14 00:00:00

  • A Genomic Perspective on the Origin and Emergence of SARS-CoV-2.

    abstract::The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data reveal about the emergence SARS-CoV-2 and discuss the gaps in our understanding of its origins. ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2020.03.035

    authors: Zhang YZ,Holmes EC

    更新日期:2020-04-16 00:00:00

  • G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase.

    abstract::The S. cerevisiae CLN genes encode cyclin homologs essential for progression from G1 to S phase. The CLN2 gene encodes a 62 kd polypeptide that accumulates periodically, peaking during G1 and decreasing rapidly thereafter, and is rapidly lost following exposure of cells to mating pheromone. Cln2 abundance can be expla...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(90)90361-h

    authors: Wittenberg C,Sugimoto K,Reed SI

    更新日期:1990-07-27 00:00:00

  • Electron microscopic visualization of recA-DNA filaments: evidence for a cyclic extension of duplex DNA.

    abstract::As visualized by electron microscopy, RecA protein binds in a highly cooperative manner to single-stranded fd DNA in solutions of 0.01 M Tris (pH 7.5). The resulting nucleoprotein filament loops are 1.25 micrometers in length, have a fiber diameter of 12 nm and show an indication of a 4.5 nm repeat along the axis of t...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(82)90055-1

    authors: Dunn K,Chrysogelos S,Griffith J

    更新日期:1982-04-01 00:00:00

  • The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product.

    abstract::Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the prot...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90538-7

    authors: Crews ST,Thomas JB,Goodman CS

    更新日期:1988-01-15 00:00:00

  • ParB-type DNA Segregation Proteins Are CTP-Dependent Molecular Switches.

    abstract::During cell division, newly replicated DNA is actively segregated to the daughter cells. In most bacteria, this process involves the DNA-binding protein ParB, which condenses the centromeric regions of sister DNA molecules into kinetochore-like structures that recruit the DNA partition ATPase ParA and the prokaroytic ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.11.015

    authors: Osorio-Valeriano M,Altegoer F,Steinchen W,Urban S,Liu Y,Bange G,Thanbichler M

    更新日期:2019-12-12 00:00:00

  • Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.

    abstract::Histone lysine methylation has been linked to the recruitment of mammalian DNA repair factor 53BP1 and putative fission yeast homolog Crb2 to DNA double-strand breaks (DSBs), but how histone recognition is achieved has not been established. Here we demonstrate that this link occurs through direct binding of 53BP1 and ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2006.10.043

    authors: Botuyan MV,Lee J,Ward IM,Kim JE,Thompson JR,Chen J,Mer G

    更新日期:2006-12-29 00:00:00

  • CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration.

    abstract::Neurodegenerative diseases can occur so early as to affect neurodevelopment. From a cohort of more than 2,000 consanguineous families with childhood neurological disease, we identified a founder mutation in four independent pedigrees in cleavage and polyadenylation factor I subunit 1 (CLP1). CLP1 is a multifunctional ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2014.03.049

    authors: Schaffer AE,Eggens VR,Caglayan AO,Reuter MS,Scott E,Coufal NG,Silhavy JL,Xue Y,Kayserili H,Yasuno K,Rosti RO,Abdellateef M,Caglar C,Kasher PR,Cazemier JL,Weterman MA,Cantagrel V,Cai N,Zweier C,Altunoglu U,Satkin N

    更新日期:2014-04-24 00:00:00

  • Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.

    abstract::Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membr...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)81742-0

    authors: Fernandez I,Ubach J,Dulubova I,Zhang X,Südhof TC,Rizo J

    更新日期:1998-09-18 00:00:00