Abstract:
:The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate.
journal_name
Celljournal_title
Cellauthors
Affara NI,Coussens LMdoi
10.1016/j.cell.2007.03.029subject
Has Abstractpub_date
2007-04-06 00:00:00pages
25-6issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(07)00397-2journal_volume
129pub_type
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