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A backup DNA repair pathway moves to the forefront.

Abstract：

:Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal translocations of lymphoid cancers (Corneo et al., 2007; Soulas-Sprauel et al., 2007; Yan et al., 2007).

journal_name

Cell

journal_title

Cell

authors

Nussenzweig A,Nussenzweig MC

doi

10.1016/j.cell.2007.10.005

subject

Has Abstract

pub_date

2007-10-19 00:00:00

pages

223-5

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(07)01273-1

journal_volume

131

pub_type

杂志文章

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