Abstract:
:In a culture system where a bifurcated Aplysia sensory neuron makes synapses with two motor neurons, repeated application of serotonin (5-HT) to one synapse produces a CREB-mediated, synapse-specific, long-term facilitation, which can be captured at the opposite synapse by a single pulse of 5-HT. Repeated pulses of 5-HT applied to the cell body of the sensory neuron produce a CREB-dependent, cell-wide facilitation, which, unlike synapse-specific facilitation, is not associated with growth and does not persist beyond 48 hr. Persistent facilitation and synapse-specific growth can be induced by a single pulse of 5-HT applied to a peripheral synapse. Thus, the short-term process initiated by a single pulse of 5-HT serves not only to produce transient facilitation, but also to mark and stabilize any synapse of the neuron for long-term facilitation by means of a covalent mark and rapamycin-sensitive local protein synthesis.
journal_name
Celljournal_title
Cellauthors
Casadio A,Martin KC,Giustetto M,Zhu H,Chen M,Bartsch D,Bailey CH,Kandel ERdoi
10.1016/s0092-8674(00)81653-0subject
Has Abstractpub_date
1999-10-15 00:00:00pages
221-37issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81653-0journal_volume
99pub_type
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