New "hogs" in Hedgehog transport and signal reception.

Abstract:

:A recent paper in Cell (Yao et al., 2006) and two papers in Developmental Cell (Tenzen et al., 2006; Zhang et al., 2006) identify a new receptor component for Hedgehog, a key morphogen in embryonic development. Many other proteins that bind to Hedgehog in the extracellular matrix or on the cell surface have been identified. In light of these recent discoveries, we discuss how these factors control the stability, transport, reception, and availability of Hedgehog in modulating Hedgehog-mediated responses.

journal_name

Cell

journal_title

Cell

authors

Wilson CW,Chuang PT

doi

10.1016/j.cell.2006.04.016

subject

Has Abstract

pub_date

2006-05-05 00:00:00

pages

435-8

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(06)00497-1

journal_volume

125

pub_type

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