Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation.

abstract：:We have prepared polyclonal antibodies to the cytoplasmic portion of the envelope glycoprotein G of vesicular stomatitis virus (VSV) by using synthetic peptides corresponding to either the 22 or 11 ultimate carboxy-terminal residues of the G as immunogens. When antibodies to the 22 residue peptide are microinjected in...

journal_title：Cell

authors： Arnheiter H,Dubois-Dalcq M,Lazzarini RA

更新日期：1984-11-01 00:00:00

abstract：:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...

journal_title：Cell

authors： Licht JD

更新日期：2015-08-27 00:00:00

abstract：:Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding to intracellular signaling. Activation of class B G protein-coupled receptors ...

journal_title：Cell

authors： Wootten D,Reynolds CA,Smith KJ,Mobarec JC,Koole C,Savage EE,Pabreja K,Simms J,Sridhar R,Furness SGB,Liu M,Thompson PE,Miller LJ,Christopoulos A,Sexton PM

更新日期：2016-06-16 00:00:00

abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...

journal_title：Cell

authors： Wilson VL,Jones PA

更新日期：1983-01-01 00:00:00

abstract：:To investigate the function of SWI/SNF in site-specific chromatin remodeling at promoters, we have used a purified system to analyze its distribution, function, and retention following recruitment by a sequence-specific transcription activator. Activator recruitment of SWI/SNF bound the complex to promoter proximal nu...

journal_title：Cell

authors： Hassan AH,Neely KE,Workman JL

更新日期：2001-03-23 00:00:00

abstract：:A novel method of affinity chromatography on insolubilized collagen-binding fragments of fibronectin was utilized to isolate a random-coil collagenous protein from culture media of mouse teratocarcinoma-derived endodermal cells. These cells also produced another collagenous protein, which did not bind to fibronectin b...

journal_title：Cell

authors： Engvall E,Bell ML,Carlsson RN,Miller EJ,Ruoslahti E

更新日期：1982-06-01 00:00:00

abstract：:We are studying mice that carry a targeted disruption of the gene encoding insulin-like growth factor II (IGF-II). Transmission of this mutation through the male germline results in heterozygous progeny that are growth deficient. In contrast, when the disrupted gene is transmitted maternally, the heterozygous offsprin...

journal_title：Cell

authors： DeChiara TM,Robertson EJ,Efstratiadis A

更新日期：1991-02-22 00:00:00

abstract：:The membrane fusion potential of influenza HA, like many viral membrane-fusion glycoproteins, is generated by proteolytic cleavage of a biosynthetic precursor. The three-dimensional structure of ectodomain of the precursor HA0 has been determined and compared with that of cleaved HA. The cleavage site is a prominent s...

journal_title：Cell

authors： Chen J,Lee KH,Steinhauer DA,Stevens DJ,Skehel JJ,Wiley DC

更新日期：1998-10-30 00:00:00

abstract：:Telomerase activity was demonstrated in cell-free extracts from S. cerevisiae through the use of a PCR-based assay. As expected, this activity was eliminated by RNase or phenol treatment of the extract and was dependent on dGTP and dTTP. Telomerase was not detected in extracts prepared from cells grown for approximate...

journal_title：Cell

authors： Lin JJ,Zakian VA

更新日期：1995-06-30 00:00:00

abstract：:We describe the isolation and characterization of two unusual amber suppressor forms of T4 tRNALeu. The sequences of the suppressor tRNAs can be described as hybrids of wild-type tRNALeu and suppressor tRNAGln molecules: the chain lengths and majority of the nucleotide residues corresponded to tRNALeu, but CUA anticod...

journal_title：Cell

authors： McClain WH,Foss K

更新日期：1984-08-01 00:00:00

abstract：:The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a ne...

journal_title：Cell

authors： Welsh TJ,Shen Y,Levin A,Knowles TPJ

更新日期：2018-11-29 00:00:00

abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...

journal_title：Cell

authors： Ring BZ,Yarnell WS,Roberts JW

更新日期：1996-08-09 00:00:00

abstract：:Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the ...

journal_title：Cell

authors： Xing C,Zhuang Y,Xu TH,Feng Z,Zhou XE,Chen M,Wang L,Meng X,Xue Y,Wang J,Liu H,McGuire TF,Zhao G,Melcher K,Zhang C,Xu HE,Xie XQ

更新日期：2020-02-20 00:00:00

abstract：:Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA. ...

journal_title：Cell

authors： Friedberg EC,Fischhaber PL,Kisker C

更新日期：2001-10-05 00:00:00

abstract：:Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the mol...

journal_title：Cell

authors： Li Q,Zhou H,Wurtele H,Davies B,Horazdovsky B,Verreault A,Zhang Z

更新日期：2008-07-25 00:00:00

abstract：:Major depressive disorder (MDD) patients display a common but often variable set of symptoms making successful, sustained treatment difficult to achieve. Separate depressive symptoms may be encoded by differential changes in distinct circuits in the brain, yet how discrete circuits underlie behavioral subsets of depre...

journal_title：Cell

authors： Knowland D,Lilascharoen V,Pacia CP,Shin S,Wang EH,Lim BK

更新日期：2017-07-13 00:00:00

abstract：:In a culture system where a bifurcated Aplysia sensory neuron makes synapses with two motor neurons, repeated application of serotonin (5-HT) to one synapse produces a CREB-mediated, synapse-specific, long-term facilitation, which can be captured at the opposite synapse by a single pulse of 5-HT. Repeated pulses of 5-...

journal_title：Cell

authors： Casadio A,Martin KC,Giustetto M,Zhu H,Chen M,Bartsch D,Bailey CH,Kandel ER

更新日期：1999-10-15 00:00:00

abstract：:In two companion reports, the TRACERx consortium investigates tumor heterogeneity and evolution in early-stage non-small cell lung cancer. The studies highlight the prognostic value of copy-number heterogeneity assessment in tumor biopsies and circulating tumor DNA detection in plasma and suggest that tracking the evo...

journal_title：Cell

authors： Hsu PP,Shaw AT

更新日期：2017-05-18 00:00:00

abstract：:Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-asso...

journal_title：Cell

authors： Dustin ML

更新日期：2008-03-07 00:00:00

abstract：:In the mouse, the zona pellucida (ZP) glycoprotein ZP3 both binds intact sperm and induces acrosomal exocytosis. The subsequent signaling pathway(s) is still uncertain, but Gi-like proteins have been implicated. By analogy with other signal transduction mechanisms, we examined anti-phosphotyrosine antibody reactivity ...

journal_title：Cell

authors： Leyton L,Saling P

更新日期：1989-06-30 00:00:00

abstract：:In a 4-cell stage C. elegans embryo, signaling by the P2 blastomere induces anterior-posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have taken genetic and reverse genetic approaches toward understanding the molecular basis for this induction. These studies have identified a set of...

journal_title：Cell

authors： Rocheleau CE,Downs WD,Lin R,Wittmann C,Bei Y,Cha YH,Ali M,Priess JR,Mello CC

更新日期：1997-08-22 00:00:00

abstract：:Mutant strains of D. discoideum are described that can complete morphogenesis and cytodifferentiation but which express vastly reduced levels of the galactose-binding lectins discoidin I and II (less than 1% and 1%-2% respectively) compared to the wild-type control. Mutant cells proceeding through development lack lec...

journal_title：Cell

authors： Alexander S,Shinnick TM,Lerner RA

更新日期：1983-09-01 00:00:00

abstract：:We have isolated the bovine and human genes for Müllerian inhibiting substance (MIS), a testicular glycoprotein that causes regression of the Müllerian duct during development of the male embryo. The mRNA sequence of bovine MIS, determined from an analysis of cDNA and genomic clones, codes for a protein of 575 amino a...

journal_title：Cell

authors： Cate RL,Mattaliano RJ,Hession C,Tizard R,Farber NM,Cheung A,Ninfa EG,Frey AZ,Gash DJ,Chow EP

更新日期：1986-06-06 00:00:00

abstract：:Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations alo...

journal_title：Cell

authors： Dollé P,Dierich A,LeMeur M,Schimmang T,Schuhbaur B,Chambon P,Duboule D

更新日期：1993-11-05 00:00:00

abstract：:All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-trans RA to bind to RXR suggests that it may be metabolized to a more active high affinity ligand. We report here an experimental app...

journal_title：Cell

authors： Heyman RA,Mangelsdorf DJ,Dyck JA,Stein RB,Eichele G,Evans RM,Thaller C

更新日期：1992-01-24 00:00:00

abstract：:The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...

journal_title：Cell

authors： Astell CR,Smith M,Chow MB,Ward DC

更新日期：1979-07-01 00:00:00

abstract：:Nontransformed pre-B cells were induced to differentiate in vitro along several different but predictable pathways with only dendritic cells (DC) and concanavalin A-stimulated T lymphocytes. DC-T from spleen induced secretion of only IgM, whereas DC-T from Peyer's patches induced high levels of IgA and intermediate le...

journal_title：Cell

authors： Spalding DM,Griffin JA

更新日期：1986-02-14 00:00:00

abstract：:Fibrillar protein aggregates are the major pathological hallmark of several incurable, age-related, neurodegenerative disorders. These aggregates typically contain aggregation-prone pathogenic proteins, such as amyloid-beta in Alzheimer's disease and alpha-synuclein in Parkinson's disease. It is, however, poorly under...

journal_title：Cell

authors： van Ham TJ,Holmberg MA,van der Goot AT,Teuling E,Garcia-Arencibia M,Kim HE,Du D,Thijssen KL,Wiersma M,Burggraaff R,van Bergeijk P,van Rheenen J,Jerre van Veluw G,Hofstra RM,Rubinsztein DC,Nollen EA

更新日期：2010-08-20 00:00:00

abstract：:Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes...

journal_title：Cell

authors： Barker D,Schafer M,White R

更新日期：1984-01-01 00:00:00

abstract：:Eukaryotic genomes are packaged into nucleosomes whose position and chemical modification state can profoundly influence regulation of gene expression. We profiled nucleosome modifications across the yeast genome using chromatin immunoprecipitation coupled with DNA microarrays to produce high-resolution genome-wide ma...

journal_title：Cell

authors： Pokholok DK,Harbison CT,Levine S,Cole M,Hannett NM,Lee TI,Bell GW,Walker K,Rolfe PA,Herbolsheimer E,Zeitlinger J,Lewitter F,Gifford DK,Young RA

更新日期：2005-08-26 00:00:00