9-cis retinoic acid is a high affinity ligand for the retinoid X receptor.

Abstract:

:All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-trans RA to bind to RXR suggests that it may be metabolized to a more active high affinity ligand. We report here an experimental approach that has identified 9-cis RA as an RXR ligand. It is up to 40-fold more potent than all-trans RA in transfection assays and binds with high affinity. The production of 9-cis RA in cultured cells and the identification of this molecule in liver and kidney demonstrates the existence of this molecule in living organisms. The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways.

journal_name

Cell

journal_title

Cell

authors

Heyman RA,Mangelsdorf DJ,Dyck JA,Stein RB,Eichele G,Evans RM,Thaller C

doi

10.1016/0092-8674(92)90479-v

subject

Has Abstract

pub_date

1992-01-24 00:00:00

pages

397-406

issue

2

eissn

0092-8674

issn

1097-4172

pii

0092-8674(92)90479-V

journal_volume

68

pub_type

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