Abstract：
:All-trans retinoic acid (RA) has previously been shown to modulate the transcriptional properties of the retinoic acid receptor (RAR) and retinoid X receptor (RXR). The inability of all-trans RA to bind to RXR suggests that it may be metabolized to a more active high affinity ligand. We report here an experimental approach that has identified 9-cis RA as an RXR ligand. It is up to 40-fold more potent than all-trans RA in transfection assays and binds with high affinity. The production of 9-cis RA in cultured cells and the identification of this molecule in liver and kidney demonstrates the existence of this molecule in living organisms. The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways.
journal_name
Celljournal_title
Cellauthors
Heyman RA,Mangelsdorf DJ,Dyck JA,Stein RB,Eichele G,Evans RM,Thaller Cdoi
10.1016/0092-8674(92)90479-vsubject
Has Abstractpub_date
1992-01-24 00:00:00pages
397-406issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(92)90479-Vjournal_volume
68pub_type
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