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Differential response of multiple epsilon-globin cap sites to cis- and trans-acting controls.

Abstract：

:The human epsilon-globin gene has a number of alternative transcription-initiation sites located upstream of the canonical mRNA cap site. In three nonerythroid cell lines, "leaky" epsilon-globin transcription occurs exclusively from one of these upstream sites, the -200 cap site. Using a transient expression assay, we have shown that transcription initiation from the -200 cap site and the major cap site can be independently regulated in response to plasmid replication, SV40 enhancer sequences in cis, and the adenovirus E1A gene in trans. The -200 cap site is located within a region of S1 hypersensitivity in the supercoiled plasmid, and in the absence of viral enhancer sequences it is the main initiation site following transfection into a number of cell lines. We suggest that the -200 cap site acts as a polymerase entry site by virtue of its accessible chromatin structure. The efficiency of polymerase binding at this site may be altered by trans-acting regulatory molecules.

journal_name

Cell

journal_title

Cell

authors

Allan M,Zhu JD,Montague P,Paul J

doi

10.1016/0092-8674(84)90495-1

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

399-407

issue

2

eissn

0092-8674

issn

1097-4172

pii

0092-8674(84)90495-1

journal_volume

38

pub_type

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