Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.

abstract：:The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails the association of beta-catenin with nuclear TCF/LEF proteins and results in transcriptional activation of target genes. The mechanism by which nuclear beta-catenin controls transcription is largely unknown. Here we genetically...

journal_title：Cell

authors： Mosimann C,Hausmann G,Basler K

更新日期：2006-04-21 00:00:00

abstract：:The human multidrug resistance P-glycoprotein is an active transporter that pumps cytotoxic drugs out of cells. Expression of P-glycoprotein is also associated with a volume-activated chloride channel. Here we address the relationship between these two functions. Drug transport requires ATP hydrolysis while, in contra...

journal_title：Cell

authors： Gill DR,Hyde SC,Higgins CF,Valverde MA,Mintenig GM,Sepúlveda FV

更新日期：1992-10-02 00:00:00

abstract：:The global financial crisis has hit biotech companies hard both in the US and Europe as venture capital dries up. Finding new sources of long-term financing for translating research into new therapeutics will be essential for maintaining innovation and new drug development by biotech companies. ...

journal_title：Cell

authors： Karberg S

更新日期：2009-08-07 00:00:00

abstract：:Initiator tRNAs from the cytoplasm of salmon testes and salmon liver have been purified. The nucleotide sequence of these initiator tRNAs has been determined and found identical to that of initiator tRNA from mammalian cytoplasm. The only difference is the extent of modification of the nuceloside located between the d...

journal_title：Cell

authors： Gillum AM,Urquhart N,Smith M,RajBhandary UL

更新日期：1975-11-01 00:00:00

abstract：:Chimeric histocompatibility genes encoding the amino-terminal (beta 1) domain of the class II Ak beta polypeptide and the carboxy-terminal (C2, transmembrane, and intracytoplasmic) domains of either the class I H-2Ld or H-2Dd molecules were stably introduced into mouse L cells. Although both were transcribed, only 5' ...

journal_title：Cell

authors： McCluskey J,Germain RN,Margulies DH

更新日期：1985-02-01 00:00:00

abstract：:Nuclear DNA from eucaryotes contains a significant fraction which forms duplexes very rapidly and also independently of the DNA concentration. This fraction can be isolated by adsorption to hydroxylapatite and has been called foldback DNA (Britten and Smith, 1970). Here we extend previous studies to show that the fold...

journal_title：Cell

authors： Perlman S,Phillips C,Bishop JO

更新日期：1976-05-01 00:00:00

abstract：:We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithel...

journal_title：Cell

authors： Müller U,Wang D,Denda S,Meneses JJ,Pedersen RA,Reichardt LF

更新日期：1997-03-07 00:00:00

abstract：:Subcellular compartments in which folding and assembly of proteins occur seem to have a set of PCB proteins capable of mediating these and related processes, such as translocation across membranes. When a domain of a polypeptide chain emerges from a ribosome during synthesis or from the distal side of a membrane durin...

journal_title：Cell

authors： Rothman JE

更新日期：1989-11-17 00:00:00

abstract：:We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...

journal_title：Cell

authors： Kasthuri N,Hayworth KJ,Berger DR,Schalek RL,Conchello JA,Knowles-Barley S,Lee D,Vázquez-Reina A,Kaynig V,Jones TR,Roberts M,Morgan JL,Tapia JC,Seung HS,Roncal WG,Vogelstein JT,Burns R,Sussman DL,Priebe CE,Pfister H

更新日期：2015-07-30 00:00:00

abstract：:During eukaryotic translation initiation, initiator tRNA does not insert fully into the P decoding site on the 40S ribosomal subunit. This conformation (POUT) is compatible with scanning mRNA for the AUG start codon. Base pairing with AUG is thought to promote isomerization to a more stable conformation (PIN) that arr...

journal_title：Cell

authors： Hussain T,Llácer JL,Fernández IS,Munoz A,Martin-Marcos P,Savva CG,Lorsch JR,Hinnebusch AG,Ramakrishnan V

更新日期：2014-10-23 00:00:00

abstract：:Removal of histone H1 produces a transition in the structure of chromatin fibers as observed by electron microscopy. Chromatin containing all histone proteins appears as fibers with a diameter of about 250 A. The nucleosomes within these fibers are closely packed. If histone H1 is selectively removed with 50-100 mM Na...

journal_title：Cell

authors： Thoma F,Koller T

更新日期：1977-09-01 00:00:00

abstract：:Maintaining the pluripotency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum. The paper from Ying et al. in this issue of Cell shows that BMP (bone morphogenetic protein) can replace serum in this capacity, defining molecular requirements for ES cell self-renewal. ...

journal_title：Cell

authors： Temple S

更新日期：2003-10-31 00:00:00

abstract：:Fos protein can trans-activate AP-1-dependent gene expression and trans-repress the c-fos promoter. Although we find that trans-repression is enhanced by coexpression of c-Jun, it does not require any of the AP-1 or ATF sites in the mouse c-fos promoter. A major target for repression is the serum response element (SRE...

journal_title：Cell

authors： Lucibello FC,Lowag C,Neuberg M,Müller R

更新日期：1989-12-22 00:00:00

abstract：:In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. These kinases coordinately regulate various cellular ...

journal_title：Cell

authors： Steffen KK,MacKay VL,Kerr EO,Tsuchiya M,Hu D,Fox LA,Dang N,Johnston ED,Oakes JA,Tchao BN,Pak DN,Fields S,Kennedy BK,Kaeberlein M

更新日期：2008-04-18 00:00:00

abstract：:The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. Th...

journal_title：Cell

authors： Affara NI,Coussens LM

更新日期：2007-04-06 00:00:00

abstract：:We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal...

journal_title：Cell

authors： Bassing CH,Suh H,Ferguson DO,Chua KF,Manis J,Eckersdorff M,Gleason M,Bronson R,Lee C,Alt FW

更新日期：2003-08-08 00:00:00

abstract：:Clec16a has been identified as a disease susceptibility gene for type 1 diabetes, multiple sclerosis, and adrenal dysfunction, but its function is unknown. Here we report that Clec16a is a membrane-associated endosomal protein that interacts with E3 ubiquitin ligase Nrdp1. Loss of Clec16a leads to an increase in the N...

journal_title：Cell

authors： Soleimanpour SA,Gupta A,Bakay M,Ferrari AM,Groff DN,Fadista J,Spruce LA,Kushner JA,Groop L,Seeholzer SH,Kaufman BA,Hakonarson H,Stoffers DA

更新日期：2014-06-19 00:00:00

abstract：:Genomic Xenopus borealis oocyte-specific 5S DNA (Xbo) contains clusters of 5S rRNA genes. The number of genes varies among clusters, and the distance between genes within a cluster is about 80 nucleotides. The spacer DNA between gene clusters is AT-rich and heterogeneous in length due in part to variable numbers of a ...

journal_title：Cell

authors： Korn LJ,Brown DD

更新日期：1978-12-01 00:00:00

abstract：:Inward rectifier K+ channels mediate the K+ conductance at resting potential in many types of cell. Since these K+ channels do not pass outward currents (inward rectification) when the cell membrane is depolarized beyond a trigger threshold, they play an important role in controlling excitability. Both a highly voltag...

journal_title：Cell

authors： Fakler B,Brändle U,Glowatzki E,Weidemann S,Zenner HP,Ruppersberg JP

更新日期：1995-01-13 00:00:00

abstract：:There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by...

journal_title：Cell

authors： Fischbach MA

更新日期：2018-08-09 00:00:00

abstract：:Transcription of U1 small nuclear RNA from a 592 bp fragment of human DNA was analyzed in vivo and in vitro. When injected into Xenopus laevis oocyte nuclei, the cloned DNA is transcribed by RNA polymerase II to make human U1 snRNA. Thus the sequences of this fragment are sufficient for expression of the U1 snRNA gene...

journal_title：Cell

authors： Murphy JT,Burgess RR,Dahlberg JE,Lund E

更新日期：1982-05-01 00:00:00

abstract：:Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oc...

journal_title：Cell

authors： Strubin M,Newell JW,Matthias P

更新日期：1995-02-10 00:00:00

abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...

journal_title：Cell

authors： Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H

更新日期：2020-04-30 00:00:00

abstract：:DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...

journal_title：Cell

authors： Räschle M,Knipscheer P,Enoiu M,Angelov T,Sun J,Griffith JD,Ellenberger TE,Schärer OD,Walter JC

更新日期：2008-09-19 00:00:00

abstract：:Mutations at the mouse tottering (tg) locus cause a delayed-onset, recessive neurological disorder resulting in ataxia, motor seizures, and behavioral absence seizures resembling petit mal epilepsy in humans. A more severe allele, leaner (tg(la)), also shows a slow, selective degeneration of cerebellar neurons. By pos...

journal_title：Cell

authors： Fletcher CF,Lutz CM,O'Sullivan TN,Shaughnessy JD Jr,Hawkes R,Frankel WN,Copeland NG,Jenkins NA

更新日期：1996-11-15 00:00:00

abstract：:The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...

journal_title：Cell

authors： Liu Y,Schiff M,Czymmek K,Tallóczy Z,Levine B,Dinesh-Kumar SP

更新日期：2005-05-20 00:00:00

abstract：:The hsp 70 gene of Drosophila contains three domains to which a heat shock gene specific transcription factor (HSTF) binds. In addition to the previously described 55 bp binding domain proximal to the TAT homology, there are two 25 bp binding sites farther upstream. Footprinting studies with 5' and 3' deletion mutatio...

journal_title：Cell

authors： Topol J,Ruden DM,Parker CS

更新日期：1985-09-01 00:00:00

abstract：:Cell polarity is critical for T lymphocyte movement during their hunt for antigen-bearing cells and for infected target cells. In this issue of Cell, Yeh et al. (2008) now reveal a direct link between T cell polarity and the production of proinflammatory cytokines in mice lacking the class I MHC-restricted T cell-asso...

journal_title：Cell

authors： Dustin ML

更新日期：2008-03-07 00:00:00

abstract：:Using double-label quantitative immunoelectron microscopy on ultrathin cryosections of rat liver, we have compared the endocytotic pathways of the receptors for asialoglycoprotein (ASGP-R), mannose-6-phosphate ligands (MP-R), and polymeric IgA (IgA-R). All three were found within the Golgi complex, along the entire pl...

journal_title：Cell

authors： Geuze HJ,Slot JW,Strous GJ,Peppard J,von Figura K,Hasilik A,Schwartz AL

更新日期：1984-05-01 00:00:00

abstract：:Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during agi...

journal_title：Cell

authors： Walther DM,Kasturi P,Zheng M,Pinkert S,Vecchi G,Ciryam P,Morimoto RI,Dobson CM,Vendruscolo M,Mann M,Hartl FU

更新日期：2015-05-07 00:00:00