Neuronal Computation Underlying Inferential Reasoning in Humans and Mice.


:Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions; however, the underlying neuronal computation remains unknown. Here, we use a multi-day cross-species approach in humans and mice to report the functional anatomy and neuronal computation underlying inferential decisions. We show that during successful inference, the mammalian brain uses a hippocampal prospective code to forecast temporally structured learned associations. Moreover, during resting behavior, coactivation of hippocampal cells in sharp-wave/ripples represent inferred relationships that include reward, thereby "joining-the-dots" between events that have not been observed together but lead to profitable outcomes. Computing mnemonic links in this manner may provide an important mechanism to build a cognitive map that stretches beyond direct experience, thus supporting flexible behavior.






Barron HC,Reeve HM,Koolschijn RS,Perestenko PV,Shpektor A,Nili H,Rothaermel R,Campo-Urriza N,O'Reilly JX,Bannerman DM,Behrens TEJ,Dupret D




Has Abstract


2020-10-01 00:00:00
















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    authors: Brockdorff N,Ashworth A,Kay GF,McCabe VM,Norris DP,Cooper PJ,Swift S,Rastan S

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    authors: Rinke J,Steitz JA

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    authors: Tang JC,Szikra T,Kozorovitskiy Y,Teixiera M,Sabatini BL,Roska B,Cepko CL

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    authors: Schejter ED,Segal D,Glazer L,Shilo BZ

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    authors: Pettersson U,Philipson L

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    authors: Morrison DK,Moyer RW

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    authors: Hall AC,Lucas FR,Salinas PC

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    pub_type: 杂志文章


    authors: Kasthuri N,Hayworth KJ,Berger DR,Schalek RL,Conchello JA,Knowles-Barley S,Lee D,Vázquez-Reina A,Kaynig V,Jones TR,Roberts M,Morgan JL,Tapia JC,Seung HS,Roncal WG,Vogelstein JT,Burns R,Sussman DL,Priebe CE,Pfister H

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