Neuronal Computation Underlying Inferential Reasoning in Humans and Mice.

abstract：:Certain tRNAs in S. cerevisiae (tRNATyr and tRNAPhe) arise via precursor molecules which are mature at the 5' and 3' termini but contain intervening sequences adjacent to the anticodon (Knapp et al., 1978; O'Farrell et al., 1978). In addition to these molecules, precursors to several other tRNAs accumulate in a temper...

journal_title：Cell

authors： Etcheverry T,Colby D,Guthrie C

更新日期：1979-09-01 00:00:00

abstract：:Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate ce...

journal_title：Cell

authors： Tan L,Zhang KX,Pecot MY,Nagarkar-Jaiswal S,Lee PT,Takemura SY,McEwen JM,Nern A,Xu S,Tadros W,Chen Z,Zinn K,Bellen HJ,Morey M,Zipursky SL

更新日期：2015-12-17 00:00:00

abstract：:The synthesis and secretion of plasminogen activator by cultured macrophages can be induced and stimulated by concanavalin A and by phorbol myristate acetate, and inhibited by such agents as glucocorticoids, mitotic inhibitors and compounds affecting cAMP metabolism. By the manipulation of stimulatory and inhibitory i...

journal_title：Cell

authors： Vassalli JD,Hamilton J,Reich E

更新日期：1977-07-01 00:00:00

abstract：:During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry. ...

journal_title：Cell

authors： Chernomordik LV,Kozlov MM

更新日期：2005-11-04 00:00:00

abstract：:The Gin DNA invertase of bacteriophage Mu carries out processive recombination in which multiple rounds of exchange follow synaptic complex formation. The stereostructure of the knotted products determined by electron microscopy establishes critical features of site synapsis and DNA exchange. Surprisingly, the inverta...

journal_title：Cell

authors： Kanaar R,Klippel A,Shekhtman E,Dungan JM,Kahmann R,Cozzarelli NR

更新日期：1990-07-27 00:00:00

abstract：:The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from h...

journal_title：Cell

authors： Gee MH,Han A,Lofgren SM,Beausang JF,Mendoza JL,Birnbaum ME,Bethune MT,Fischer S,Yang X,Gomez-Eerland R,Bingham DB,Sibener LV,Fernandes RA,Velasco A,Baltimore D,Schumacher TN,Khatri P,Quake SR,Davis MM,Garcia KC

更新日期：2018-01-25 00:00:00

abstract：:The structure and organization on the Escherichia coli chromosome of the gene cluster coding for two methionine tRNAs (tRNAmMet), four glutamine tRNAs (two tRNA1Gln and two tRNA2Gln), and a previously unidentified tRNA (called tRNAx) have been studied by restriction enzyme analysis and DNA sequencing, utilizing a spec...

journal_title：Cell

authors： Nakajima N,Ozeki H,Shimura Y

更新日期：1981-01-01 00:00:00

abstract：:The general inhibition in transcriptional activity during mitosis abolishes the stress-inducible expression of the human hsp70 gene. Among the four transcription factors that bind to the human hsp70 promoter, the DNA-binding activities of three (C/EBP, GBP, and HSF1) were normal, while Sp1 showed reduced binding activ...

journal_title：Cell

authors： Martínez-Balbás MA,Dey A,Rabindran SK,Ozato K,Wu C

更新日期：1995-10-06 00:00:00

abstract：:Immunologically privileged sites express Fas ligand (FasL), which protects them from attack by activated T cells that express Fas and die upon contact with FasL. In an attempt to protect nonobese diabetic mice (NOD) from autoimmune diabetes, we made FasL transgenic NOD mice using the beta cell-specific rat insulin-1 p...

journal_title：Cell

authors： Chervonsky AV,Wang Y,Wong FS,Visintin I,Flavell RA,Janeway CA Jr,Matis LA

更新日期：1997-04-04 00:00:00

abstract：:Development of microbiota-directed foods (MDFs) that selectively increase the abundance of beneficial human gut microbes, and their expressed functions, requires knowledge of both the bioactive components of MDFs and the mechanisms underlying microbe-microbe interactions. Here, gnotobiotic mice were colonized with a d...

journal_title：Cell

authors： Patnode ML,Beller ZW,Han ND,Cheng J,Peters SL,Terrapon N,Henrissat B,Le Gall S,Saulnier L,Hayashi DK,Meynier A,Vinoy S,Giannone RJ,Hettich RL,Gordon JI

更新日期：2019-09-19 00:00:00

abstract：:We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unch...

journal_title：Cell

authors： Jinks-Robertson S,Gourse RL,Nomura M

更新日期：1983-07-01 00:00:00

abstract：:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemi...

journal_title：Cell

authors： Trimarchi T,Bilal E,Ntziachristos P,Fabbri G,Dalla-Favera R,Tsirigos A,Aifantis I

更新日期：2014-07-31 00:00:00

abstract：:Proliferating cell nuclear antigen (PCNA) is a cell cycle and growth regulated protein required for replication of SV40 DNA in vitro. Its function was investigated by comparison of the replication products synthesized in its presence or absence. In the completely reconstituted replication system that contains PCNA, DN...

journal_title：Cell

authors： Prelich G,Stillman B

更新日期：1988-04-08 00:00:00

abstract：:The chicken immunoglobulin light chain repertoire has been shown to be entirely derived from a single V lambda 1-J rearranged combination. The complete coding information of the lambda locus was determined: it comprises 25 V-hybridizing elements, all of which are pseudogenes, clustered in both orientations within 19 k...

journal_title：Cell

authors： Reynaud CA,Anquez V,Grimal H,Weill JC

更新日期：1987-02-13 00:00:00

abstract：:The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found...

journal_title：Cell

authors： Meckiff BJ,Ramírez-Suástegui C,Fajardo V,Chee SJ,Kusnadi A,Simon H,Eschweiler S,Grifoni A,Pelosi E,Weiskopf D,Sette A,Ay F,Seumois G,Ottensmeier CH,Vijayanand P

更新日期：2020-11-25 00:00:00

abstract：:In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceru...

journal_title：Cell

authors： Schimmel P,Ewalt K

更新日期：2004-10-15 00:00:00

abstract：:The role of electricity in biological systems was first appreciated through electrical stimulation experiments performed by Luigi Galvani in the 18th century. These pioneering experiments demonstrated that the behavior of living tissues is governed by the flow of electrochemical species-an insight that gave rise to th...

journal_title：Cell

authors： Lee DD,Prindle A,Liu J,Süel GM

更新日期：2017-06-29 00:00:00

abstract：:The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to preven...

journal_title：Cell

authors： Schulze-Lefert P,Robatzek S

更新日期：2006-09-08 00:00:00

abstract：:We have studied the interaction of highly purified Int protein with DNA restriction fragments from the lambda phage attachment site (attP) region. Two different DNA sequences are protected by bound Int protein against partial digestion by either pancreatic DNAase or neocarzinostatin. One Int binding site includes the ...

journal_title：Cell

authors： Ross W,Landy A,Kikuchi Y,Nash H

更新日期：1979-10-01 00:00:00

abstract：:Inositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol tetrakisphosphate (InsP8/IP8), are less well characterized. We demonstrate physiologic regulation of Dictyostelium chemotaxis by InsP7 mediated ...

journal_title：Cell

authors： Luo HR,Huang YE,Chen JC,Saiardi A,Iijima M,Ye K,Huang Y,Nagata E,Devreotes P,Snyder SH

更新日期：2003-09-05 00:00:00

abstract：:Maintenance of a constant cell volume in response to extracellular or intracellular osmotic changes is critical for cellular homeostasis. Activation of a ubiquitous volume-regulated anion channel (VRAC) plays a key role in this process; however, its molecular identity in vertebrates remains unknown. Here, we used a ce...

journal_title：Cell

authors： Qiu Z,Dubin AE,Mathur J,Tu B,Reddy K,Miraglia LJ,Reinhardt J,Orth AP,Patapoutian A

更新日期：2014-04-10 00:00:00

abstract：:Adult skeletal muscle generates force in a controlled and directed manner through the contraction of highly specialized, postmitotic, multinucleated myofibers. Life-long muscle function relies on maintenance and regeneration of myofibers through a highly regulated process beginning with activation of normally quiescen...

journal_title：Cell

authors： Wagers AJ,Conboy IM

更新日期：2005-09-09 00:00:00

abstract：:To determine the extent and nature of genetic variation present in independent isolates of HTLV-III/LAV, the nucleotide sequences of the entire envelope gene and parts of gag and pol were determined for two AIDS viruses. The results indicated that variation throughout the viral genome is extensive and that the envelop...

journal_title：Cell

authors： Starcich BR,Hahn BH,Shaw GM,McNeely PD,Modrow S,Wolf H,Parks ES,Parks WP,Josephs SF,Gallo RC

更新日期：1986-06-06 00:00:00

abstract：:We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...

journal_title：Cell

authors： Boer PH,Gray MW

更新日期：1988-11-04 00:00:00

abstract：:Even a simple sensory stimulus can elicit distinct innate behaviors and sequences. During sensorimotor decisions, competitive interactions among neurons that promote distinct behaviors must ensure the selection and maintenance of one behavior, while suppressing others. The circuit implementation of these competitive i...

journal_title：Cell

authors： Jovanic T,Schneider-Mizell CM,Shao M,Masson JB,Denisov G,Fetter RD,Mensh BD,Truman JW,Cardona A,Zlatic M

更新日期：2016-10-20 00:00:00

abstract：:Release of CHO-K1 cells from plateau or stationary phase and reentry into the cell cycle is specifically and reversibly blocked at two distinct sites by the anticalmodulin drug W13. The first block occurs early during release while the cells are still at G0/G1, whereas the second occurs later in reentry during early S...

journal_title：Cell

authors： Chafouleas JG,Lagacé L,Bolton WE,Boyd AE 3rd,Means AR

更新日期：1984-01-01 00:00:00

abstract：:Synaptotagmin is one of the major integral membrane proteins of synaptic vesicles. It has been postulated to dock vesicles to their release sites, to act as the Ca2+ sensor for the release process, and to be a fusion protein during exocytosis. To clarify the function of this protein, we have undertaken a genetic analy...

journal_title：Cell

authors： DiAntonio A,Parfitt KD,Schwarz TL

更新日期：1993-07-02 00:00:00

abstract：:Plasmids containing the origin region of human mtDNA are specifically transcribed by the partially purified homologous mtRNA polymerase in vitro. Transcription of both the light and heavy strands initiates at the same sites previously identified as in vivo transcription start sites. The sequences responsible for initi...

journal_title：Cell

authors： Bogenhagen DF,Applegate EF,Yoza BK

更新日期：1984-04-01 00:00:00

abstract：:To test the functional consequence of phosphorylation of the EGF receptor at Thr 654 by protein kinase C, the normal Thr 654 human EGF receptor cDNA or a mutant encoding an Ala 654 were expressed in heterologous cells. In cell lines expressing both the Thr 654 and Ala 654 receptors, functional cell-surface Thr 654 rec...

journal_title：Cell

authors： Lin CR,Chen WS,Lazar CS,Carpenter CD,Gill GN,Evans RM,Rosenfeld MG

更新日期：1986-03-28 00:00:00

abstract：:Neurons make networks of intercellular connections. Many other cells also send out long cellular extensions and "touch" other cells far away. The extensions are intriguing, but what do they do? Possible rationales for this cell behavior include: (1) forming precise binary connections with the possibility of forming mo...

journal_title：Cell

authors： Rørth P

更新日期：2003-03-07 00:00:00