Tumor suppression by p53: fall of the triumvirate?

Abstract:

:p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressive role.

journal_name

Cell

journal_title

Cell

authors

Hock AK,Vousden KH

doi

10.1016/j.cell.2012.05.024

subject

Has Abstract

pub_date

2012-06-08 00:00:00

pages

1183-5

issue

6

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(12)00636-8

journal_volume

149

pub_type

评论,杂志文章

相关文献

CELL文献大全
  • Correlation of specific keratins with different types of epithelial differentiation: monoclonal antibody studies.

    abstract::We have prepared three monoclonal antibodies against human epidermal keratins. These antibodies were highly specific for keratins and, in combination, recognized all major epidermal keratins of several mammalian species. We have used these antibodies to study the tissue distribution of epidermis-related keratins. In v...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(82)90234-3

    authors: Tseng SC,Jarvinen MJ,Nelson WG,Huang JW,Woodcock-Mitchell J,Sun TT

    更新日期:1982-09-01 00:00:00

  • Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress.

    abstract::Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their epidermal and muscle stem cells retain a robustly rhythmic core circadian machinery. However, the osci...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2017.07.035

    authors: Solanas G,Peixoto FO,Perdiguero E,Jardí M,Ruiz-Bonilla V,Datta D,Symeonidi A,Castellanos A,Welz PS,Caballero JM,Sassone-Corsi P,Muñoz-Cánoves P,Benitah SA

    更新日期:2017-08-10 00:00:00

  • A bacteriophage RNA polymerase transcribes through a Xenopus 5S RNA gene transcription complex without disrupting it.

    abstract::Conditions are described for programming with active transcription complexes essentially all the Xenopus 5S RNA genes added to an extract of Xenopus oocyte nuclei. We call this rate enhancement. Transcription by SP6 RNA polymerase of either strand of a Xenopus 5S RNA gene is unimpeded by the presence of a complete tra...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90459-9

    authors: Wolffe AP,Jordan E,Brown DD

    更新日期:1986-02-14 00:00:00

  • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

    abstract::We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(87)90646-5

    authors: Thomas KR,Capecchi MR

    更新日期:1987-11-06 00:00:00

  • Insights into the micromechanical properties of the metaphase spindle.

    abstract::The microtubule-based metaphase spindle is subjected to forces that act in diverse orientations and over a wide range of timescales. Currently, we cannot explain how this dynamic structure generates and responds to forces while maintaining overall stability, as we have a poor understanding of its micromechanical prope...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2011.05.038

    authors: Shimamoto Y,Maeda YT,Ishiwata S,Libchaber AJ,Kapoor TM

    更新日期:2011-06-24 00:00:00

  • Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia.

    abstract::The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB-mediated transcription and new protein synthesis. We isolated several downstream genes, one of which encodes a neuron-specific ubiquitin C-terminal...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(00)80188-9

    authors: Hegde AN,Inokuchi K,Pei W,Casadio A,Ghirardi M,Chain DG,Martin KC,Kandel ER,Schwartz JH

    更新日期:1997-04-04 00:00:00

  • Mechanism of replication-coupled DNA interstrand crosslink repair.

    abstract::DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2008.08.030

    authors: Räschle M,Knipscheer P,Enoiu M,Angelov T,Sun J,Griffith JD,Ellenberger TE,Schärer OD,Walter JC

    更新日期:2008-09-19 00:00:00

  • Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage.

    abstract::The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the u...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/s0092-8674(02)00972-8

    authors: Deverman BE,Cook BL,Manson SR,Niederhoff RA,Langer EM,Rosová I,Kulans LA,Fu X,Weinberg JS,Heinecke JW,Roth KA,Weintraub SJ

    更新日期:2002-10-04 00:00:00

  • The kinky propulsion of Spiroplasma.

    abstract::Bacteria have evolved many different means of generating movement. In this issue of Cell, Shaevitz et al. (2005) describe the swimming movement of a helical bacterium called Spiroplasma. They discover that Spiroplasma propels itself by generating two temporally distinct kinks that travel the length of the bacterium. T...

    journal_title:Cell

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.cell.2005.09.003

    authors: Wolgemuth CW,Charon NW

    更新日期:2005-09-23 00:00:00

  • Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression.

    abstract::Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By developing a high-throughput tRNA profiling method, we find that specific tRNAs are upregulated in human breast cancer cells as they gain metastatic activity. Through loss-of-function, gain-of-function, and clinical-association st...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2016.05.046

    authors: Goodarzi H,Nguyen HCB,Zhang S,Dill BD,Molina H,Tavazoie SF

    更新日期:2016-06-02 00:00:00

  • Restriction sites containing CpG show a higher frequency of polymorphism in human DNA.

    abstract::Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(84)90081-3

    authors: Barker D,Schafer M,White R

    更新日期:1984-01-01 00:00:00

  • Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.

    abstract::The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.03.030

    authors: Zhang B,Gaiteri C,Bodea LG,Wang Z,McElwee J,Podtelezhnikov AA,Zhang C,Xie T,Tran L,Dobrin R,Fluder E,Clurman B,Melquist S,Narayanan M,Suver C,Shah H,Mahajan M,Gillis T,Mysore J,MacDonald ME,Lamb JR,Bennett DA,

    更新日期:2013-04-25 00:00:00

  • Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.

    abstract::Transcription hinders replication fork progression and stability. The ATR checkpoint and specialized DNA helicases assist DNA synthesis across transcription units to protect genome integrity. Combining genomic and genetic approaches together with the analysis of replication intermediates, we searched for factors coord...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2012.09.041

    authors: Alzu A,Bermejo R,Begnis M,Lucca C,Piccini D,Carotenuto W,Saponaro M,Brambati A,Cocito A,Foiani M,Liberi G

    更新日期:2012-11-09 00:00:00

  • Transepithelial projections from basal cells are luminal sensors in pseudostratified epithelia.

    abstract::Basal cells are by definition located on the basolateral side of several epithelia, and they have never been observed reaching the lumen. Using high-resolution 3D confocal imaging, we report that basal cells extend long and slender cytoplasmic projections that not only reach toward the lumen but can cross the tight ju...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2008.10.020

    authors: Shum WW,Da Silva N,McKee M,Smith PJ,Brown D,Breton S

    更新日期:2008-12-12 00:00:00

  • The organization and amplification of two chromosomal domains containing Drosophila chorion genes.

    abstract::Drosophila chorion genes are located in two clusters, one on the X chromosome at 7F1-2 of the polytene chromosome map and a second on the third chromosome at 66D11-15. Genes in both regions undergo amplification in ovarian follicle cells prior to their expression late in oogenesis. Analysis of cloned genomic segments ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90373-1

    authors: Spradling AC

    更新日期:1981-11-01 00:00:00

  • ATP-dependent fusion of liposomes with the Golgi apparatus of perforated cells.

    abstract::We examined the interactions of lipid vesicles (liposomes) labeled with various fluorescent markers with the intracellular membranes of semi-intact ("perforated") fibroblasts. When incubations were performed in the presence of an ATP-regenerating system, both vesicle lipids and entrapped water soluble markers were tra...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90135-3

    authors: Kobayashi T,Pagano RE

    更新日期:1988-12-02 00:00:00

  • Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p.

    abstract::We have reproduced the posttranslational mode of protein translocation across the endoplasmic reticulum membrane with reconstituted proteoliposomes containing a purified complex of seven yeast proteins. This Sec complex includes a heterotrimeric Sec61p complex, homologous to that in mammals, as well as all other membr...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(95)90077-2

    authors: Panzner S,Dreier L,Hartmann E,Kostka S,Rapoport TA

    更新日期:1995-05-19 00:00:00

  • A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

    abstract::The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2015.09.053

    authors: Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

    更新日期:2015-10-22 00:00:00

  • Mutations downstream of the polyadenylation site of a Xenopus beta-globin mRNA affect the position but not the efficiency of 3' processing.

    abstract::In order to identify nucleotide sequences required for efficient and accurate polyadenylation of mRNA precursors, we have constructed a series of mutations in the X. laevis beta 1-globin gene and analyzed transcripts produced upon microinjection into Xenopus oocytes. Small deletion and linker replacement mutations, wh...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90743-9

    authors: Mason PJ,Elkington JA,Lloyd MM,Jones MB,Williams JG

    更新日期:1986-07-18 00:00:00

  • SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene.

    abstract::Monkey cells synthesizing SV40 large T antigen were lysed and the extracts immunoprecipitated with either monoclonal anti-T antibody or monoclonal antibody to p110-114, the product of the retinoblastoma susceptibility gene (Rb). T and p110-114 coprecipitated in each case, implying that the proteins are complexed with ...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(88)90559-4

    authors: DeCaprio JA,Ludlow JW,Figge J,Shew JY,Huang CM,Lee WH,Marsilio E,Paucha E,Livingston DM

    更新日期:1988-07-15 00:00:00

  • A comparison of two cloned mouse beta-globin genes and their surrounding and intervening sequences.

    abstract::The BALC/c mouse has two nonallelic beta-globin genes that appear to reside on two different Eco R1 fragments of genomic DNA. We have already cloned one of these fragments and shown that the gene encoded within it is interrupted by at least one large intervening sequence of DNA. We have now cloned and characterized th...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(78)90110-1

    authors: Tiemeier DC,Tilghman SM,Polsky FI,Seidman JG,Leder A,Edgell MH,Leder P

    更新日期:1978-06-01 00:00:00

  • Lighting up the stressed ER.

    abstract::Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2008.11.004

    authors: Kang SW,Hegde RS

    更新日期:2008-11-28 00:00:00

  • Cooperativity and rapid evolution of cobound transcription factors in closely related mammals.

    abstract::To mechanistically characterize the microevolutionary processes active in altering transcription factor (TF) binding among closely related mammals, we compared the genome-wide binding of three tissue-specific TFs that control liver gene expression in six rodents. Despite an overall fast turnover of TF binding location...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2013.07.007

    authors: Stefflova K,Thybert D,Wilson MD,Streeter I,Aleksic J,Karagianni P,Brazma A,Adams DJ,Talianidis I,Marioni JC,Flicek P,Odom DT

    更新日期:2013-08-01 00:00:00

  • Spinning the web of cell fate.

    abstract::Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that the lamina forms a dynamic framework critical for genome function, cellular identity, and developmental potential. ...

    journal_title:Cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.cell.2013.02.052

    authors: Van Bortle K,Corces VG

    更新日期:2013-03-14 00:00:00

  • Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression.

    abstract::ETS transcription factors ETV2, FLI1, and ERG1 specify pluripotent stem cells into induced vascular endothelial cells (iVECs). However, iVECs are unstable and drift toward nonvascular cells. We show that human midgestation c-Kit(-) lineage-committed amniotic cells (ACs) can be reprogrammed into vascular endothelial ce...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2012.09.032

    authors: Ginsberg M,James D,Ding BS,Nolan D,Geng F,Butler JM,Schachterle W,Pulijaal VR,Mathew S,Chasen ST,Xiang J,Rosenwaks Z,Shido K,Elemento O,Rabbany SY,Rafii S

    更新日期:2012-10-26 00:00:00

  • Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.

    abstract::A cDNA clone encoding a novel hematopoietic growth factor activity produced by a gibbon T cell line has been identified using a mammalian cell expression cloning system. The sequence of this cDNA proved to have significant homology to the sequence encoding murine interleukin 3 (IL-3). The human gene, which was readily...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(86)90360-0

    authors: Yang YC,Ciarletta AB,Temple PA,Chung MP,Kovacic S,Witek-Giannotti JS,Leary AC,Kriz R,Donahue RE,Wong GG

    更新日期:1986-10-10 00:00:00

  • Neuronal Small RNAs Control Behavior Transgenerationally.

    abstract::It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthe...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2019.04.029

    authors: Posner R,Toker IA,Antonova O,Star E,Anava S,Azmon E,Hendricks M,Bracha S,Gingold H,Rechavi O

    更新日期:2019-06-13 00:00:00

  • A tethering complex recruits SNAREs and grabs vesicles.

    abstract::Protein tethers can bridge gaps between membranes. Ren et al. (2009) now provide evidence that the yeast Dsl1 complex tethers vesicles to the endoplasmic reticulum (ER) by binding ER SNARE proteins at its base and capturing vesicles using a loop region that extends 20 nm from the ER membrane. ...

    journal_title:Cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.cell.2009.11.041

    authors: Schmitt HD,Jahn R

    更新日期:2009-12-11 00:00:00

  • Organization and structure of an E. coli tRNA operon containing seven tRNA genes.

    abstract::The structure and organization on the Escherichia coli chromosome of the gene cluster coding for two methionine tRNAs (tRNAmMet), four glutamine tRNAs (two tRNA1Gln and two tRNA2Gln), and a previously unidentified tRNA (called tRNAx) have been studied by restriction enzyme analysis and DNA sequencing, utilizing a spec...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/0092-8674(81)90288-9

    authors: Nakajima N,Ozeki H,Shimura Y

    更新日期:1981-01-01 00:00:00

  • Prokaryotic Argonautes Function beyond Immunity by Unlinking Replicating Chromosomes.

    abstract::Eukaryotic Argonaute proteins strictly mediate RNA-guided RNA interference. In contrast, prokaryotic Argonautes can utilize DNA guides to target complementary DNA sequences to protect their hosts against invading DNA. In this issue of Cell, Jolly and colleagues demonstrate that Thermus thermophilus Argonaute additiona...

    journal_title:Cell

    pub_type: 杂志文章

    doi:10.1016/j.cell.2020.08.037

    authors: Swarts DC

    更新日期:2020-09-17 00:00:00