Spinning the web of cell fate.

abstract：:Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) ...

journal_title：Cell

authors： Aid M,Abbink P,Larocca RA,Boyd M,Nityanandam R,Nanayakkara O,Martinot AJ,Moseley ET,Blass E,Borducchi EN,Chandrashekar A,Brinkman AL,Molloy K,Jetton D,Tartaglia LJ,Liu J,Best K,Perelson AS,De La Barrera RA,Lewis MG

更新日期：2017-05-04 00:00:00

abstract：:Investigating the family tree of a tumor to identify its cellular origins is a daunting task. Liu et al. (2011) now use an elegant lineage tracing technique (MADM) to visualize glioma from its earliest stages. They show that mutations originally induced in neural stem cells lie dormant and only trigger malignant trans...

journal_title：Cell

authors： Sukhdeo K,Hambardzumyan D,Rich JN

更新日期：2011-07-22 00:00:00

abstract：:To test the functional consequence of phosphorylation of the EGF receptor at Thr 654 by protein kinase C, the normal Thr 654 human EGF receptor cDNA or a mutant encoding an Ala 654 were expressed in heterologous cells. In cell lines expressing both the Thr 654 and Ala 654 receptors, functional cell-surface Thr 654 rec...

journal_title：Cell

authors： Lin CR,Chen WS,Lazar CS,Carpenter CD,Gill GN,Evans RM,Rosenfeld MG

更新日期：1986-03-28 00:00:00

abstract：:The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have no...

journal_title：Cell

authors： Socolovsky M,Fallon AE,Wang S,Brugnara C,Lodish HF

更新日期：1999-07-23 00:00:00

abstract：:cDNA clones of the Drosophila epidermal growth factor receptor homolog (DER) gene were isolated and sequenced. The deduced amino acid sequence shows a similar degree of homology to the human epidermal growth factor receptor and to the rat and human neu proteins; the most striking difference is the addition of a third ...

journal_title：Cell

authors： Schejter ED,Segal D,Glazer L,Shilo BZ

更新日期：1986-09-26 00:00:00

abstract：:The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...

journal_title：Cell

authors： Liu Y,Schiff M,Czymmek K,Tallóczy Z,Levine B,Dinesh-Kumar SP

更新日期：2005-05-20 00:00:00

abstract：:The Bcl-2 family member Bax translocates from the cytosol to mitochondria, where it oligomerizes and permeabilizes the mitochondrial outer membrane to promote apoptosis. Bax activity is counteracted by prosurvival Bcl-2 proteins, but how they inhibit Bax remains controversial because they neither colocalize nor form s...

journal_title：Cell

authors： Edlich F,Banerjee S,Suzuki M,Cleland MM,Arnoult D,Wang C,Neutzner A,Tjandra N,Youle RJ

更新日期：2011-04-01 00:00:00

abstract：:The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...

journal_title：Cell

authors： Zhu PJ,Huang W,Kalikulov D,Yoo JW,Placzek AN,Stoica L,Zhou H,Bell JC,Friedlander MJ,Krnjević K,Noebels JL,Costa-Mattioli M

更新日期：2011-12-09 00:00:00

abstract：:Understanding how transcriptional enhancers control over 20,000 protein-coding genes to maintain cell-type-specific gene expression programs in all human cells is a fundamental challenge in regulatory biology. Recent studies suggest that gene regulatory elements and their target genes generally occur within insulated ...

journal_title：Cell

authors： Hnisz D,Day DS,Young RA

更新日期：2016-11-17 00:00:00

abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...

journal_title：Cell

authors： Shi Z,Graber ZT,Baumgart T,Stone HA,Cohen AE

更新日期：2018-12-13 00:00:00

abstract：:Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization. Prominently, the left-right asymmetry was randomized in the heart loop and the direction of embry...

journal_title：Cell

authors： Nonaka S,Tanaka Y,Okada Y,Takeda S,Harada A,Kanai Y,Kido M,Hirokawa N

更新日期：1998-12-11 00:00:00

abstract：:We have determined the complete 9202 nucleotide sequence of the visna lentivirus. The deduced genetic organization most closely resembles that of the AIDS retrovirus in that there is a novel central region separating pol and env. Moreover, there is a close phylogenetic relationship between the conserved reverse transc...

journal_title：Cell

authors： Sonigo P,Alizon M,Staskus K,Klatzmann D,Cole S,Danos O,Retzel E,Tiollais P,Haase A,Wain-Hobson S

更新日期：1985-08-01 00:00:00

abstract：:A novel trimolecular mechanism of microbial attachment to mammalian host cells was characterized for the obligate intracellular pathogen Chlamydia trachomatis. Using purified glycosaminoglycans (GAGs) and specific GAG lyases, we demonstrated that a heparan sulfate-like GAG present on the surface of chlamydia organisms...

journal_title：Cell

authors： Zhang JP,Stephens RS

更新日期：1992-05-29 00:00:00

abstract：:The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that the R201C mutation ca...

journal_title：Cell

authors： Hu Q,Shokat KM

更新日期：2018-05-17 00:00:00

abstract：:During embryogenesis, cells from the ventral and dorsal parts of the somites give rise to sclerotome and dermomyotome, respectively. Dermomyotome contains skeletal muscle precursors that are determined by the MyoD family of myogenic factors. We have isolated a novel myogenic repressor, I-mf (Inhibitor of MyoD family),...

journal_title：Cell

authors： Chen CM,Kraut N,Groudine M,Weintraub H

更新日期：1996-09-06 00:00:00

abstract：:Reactivation of human cytomegalovirus (HCMV) results in severe disease in AIDS patients and immunocompromised patients receiving blood transfusions or organ or bone marrow grafts. Although the site of HCMV latency is unknown, blood cells have been implicated as a viral reservoir. In this study, we demonstrate HCMV rea...

journal_title：Cell

authors： Söderberg-Nauclér C,Fish KN,Nelson JA

更新日期：1997-10-03 00:00:00

abstract：:Neural progenitors generate distinct cell types at different stages, but the mechanisms controlling these temporal transitions are poorly understood. In the Drosophila CNS, a cascade of transcription factors, the "temporal gene cascade," has been identified that acts to alter progenitor competence over time. However, ...

journal_title：Cell

authors： Baumgardt M,Karlsson D,Terriente J,Díaz-Benjumea FJ,Thor S

更新日期：2009-11-25 00:00:00

abstract：:Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current precl...

journal_title：Cell

authors： Day CP,Merlino G,Van Dyke T

更新日期：2015-09-24 00:00:00

abstract：:Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuro...

journal_title：Cell

authors： Krashes MJ,DasGupta S,Vreede A,White B,Armstrong JD,Waddell S

更新日期：2009-10-16 00:00:00

abstract：:The yeast tropomyosin gene, designated TPM1, is present in a single copy per haploid genome and encodes a protein with a predicted molecular weight of 23.5 kd. The protein sequence is homologous to higher cell tropomyosins, including the characteristic hydrophobic-hydrophilic pseudoheptapeptide repeats. Indirect immun...

journal_title：Cell

authors： Liu HP,Bretscher A

更新日期：1989-04-21 00:00:00

abstract：:Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis. We find that satellite cells, expressing dystroglycan, support continued efficient r...

journal_title：Cell

authors： Cohn RD,Henry MD,Michele DE,Barresi R,Saito F,Moore SA,Flanagan JD,Skwarchuk MW,Robbins ME,Mendell JR,Williamson RA,Campbell KP

更新日期：2002-09-06 00:00:00

abstract：:Nucleotide sequences in two wild-type and six mutant operators in the DNA of phage lambda are compared. Strikingly similar 17 base pair units are found which we identify as the repressor binding sites. Each operator contains multiple repressor binding sites separated by A-T rich spacers. Elements of 2 fold rotational ...

journal_title：Cell

authors： Maniatis T,Ptashne M,Backman K,Kield D,Flashman S,Jeffrey A,Maurer R

更新日期：1975-06-01 00:00:00

abstract：:We have isolated and characterized a set of overlapping cDNA clones that encode the human centromere autoantigen centromere protein C (CENP-C). The identity of these clones has been established using several criteria. First, they were shown to encode a polypeptide that migrates at the expected position for CENP-C on S...

journal_title：Cell

authors： Saitoh H,Tomkiel J,Cooke CA,Ratrie H 3rd,Maurer M,Rothfield NF,Earnshaw WC

更新日期：1992-07-10 00:00:00

abstract：:Tyrosyl phosphorylation is implicated in the mechanism of insulin action. Mutation of the beta-subunit of the insulin receptor by substitution of tyrosyl residue 960 with phenylalanine had no effect on insulin-stimulated autophosphorylation or phosphotransferase activity of the purified receptor. However, unlike the n...

journal_title：Cell

authors： White MF,Livingston JN,Backer JM,Lauris V,Dull TJ,Ullrich A,Kahn CR

更新日期：1988-08-26 00:00:00

abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...

journal_title：Cell

authors： Boire A,Covic L,Agarwal A,Jacques S,Sherifi S,Kuliopulos A

更新日期：2005-02-11 00:00:00

abstract：:In eukaryotic cells, organelles and the cytoskeleton undergo highly dynamic yet organized interactions capable of orchestrating complex cellular functions. Visualizing these interactions requires noninvasive, long-duration imaging of the intracellular environment at high spatiotemporal resolution and low background. T...

journal_title：Cell

authors： Guo Y,Li D,Zhang S,Yang Y,Liu JJ,Wang X,Liu C,Milkie DE,Moore RP,Tulu US,Kiehart DP,Hu J,Lippincott-Schwartz J,Betzig E,Li D

更新日期：2018-11-15 00:00:00

abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...

journal_title：Cell

authors： Ciriello G,Gatza ML,Beck AH,Wilkerson MD,Rhie SK,Pastore A,Zhang H,McLellan M,Yau C,Kandoth C,Bowlby R,Shen H,Hayat S,Fieldhouse R,Lester SC,Tse GM,Factor RE,Collins LC,Allison KH,Chen YY,Jensen K,Johnson NB,O

更新日期：2015-10-08 00:00:00

abstract：:In this issue of Cell, Lee et al. (2006) report that the parasite Trypanosoma brucei synthesizes fatty acids in an unconventional way. T. brucei and two other trypanosomes use enzymes called elongases to synthesize myristate, a fourteen carbon (C14) fatty acid essential for pathogenesis. This is an unexpected finding ...

journal_title：Cell

authors： Cronan JE

更新日期：2006-08-25 00:00:00

abstract：:In this issue, Metzis et al., demonstrate that in the development of the central nervous system, patterning along the anterior-posterior axis precedes acquisition of neural identity. This contrasts with the prevailing view that neural identity comes first, providing a new window on the origins of the brain and spinal ...

journal_title：Cell

authors： Simon CS,Hadjantonakis AK

更新日期：2018-11-01 00:00:00

abstract：:Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase is recruited during transcriptional activation. Here we describe a process, deimination, that converts histone arginine to citrul...

journal_title：Cell

authors： Cuthbert GL,Daujat S,Snowden AW,Erdjument-Bromage H,Hagiwara T,Yamada M,Schneider R,Gregory PD,Tempst P,Bannister AJ,Kouzarides T

更新日期：2004-09-03 00:00:00