Abstract：
:Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory.
journal_name
Celljournal_title
Cellauthors
Krashes MJ,DasGupta S,Vreede A,White B,Armstrong JD,Waddell Sdoi
10.1016/j.cell.2009.08.035subject
Has Abstractpub_date
2009-10-16 00:00:00pages
416-27issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(09)01105-2journal_volume
139pub_type
杂志文章相关文献
CELL文献大全abstract：:The general transcription factor TFIID is a multiprotein complex containing the TATA-binding protein and several associated factors (TAFs), some of which may function as coactivators that are essential for activated, but not basal, transcription. Here we describe the isolation and characterization of the first gene en...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90664-c
更新日期：1993-01-29 00:00:00
abstract：:The large tumor antigen (LTag) of simian virus 40, an AAA(+) protein, is a hexameric helicase essential for viral DNA replication in eukaryotic cells. LTag functions as an efficient molecular machine powered by ATP binding and hydrolysis for origin DNA melting and replication fork unwinding. To understand how ATP bind...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.09.017
更新日期：2004-10-01 00:00:00
abstract：:The 5' terminal structure of the mRNA synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus in the presence of S-adenosyl-L-methione consists of 7-methyl guanosine linked to 2'-O-methyl adenosine through a 5'-5' pyrophosphate bond as m7G(5')ppp(5')A-m-p ... The alpha and beta phosp...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90091-4
更新日期：1975-05-01 00:00:00
abstract：:The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 prol...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.07.026
更新日期：2006-09-08 00:00:00
abstract：:Dopamine neurons promote learning by processing recent changes in reward values, such that reward may be maximized. However, such a flexible signal is not suitable for habitual behaviors that are sustained regardless of recent changes in reward outcome. We discovered a type of dopamine neuron in the monkey substantia ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.10.063
更新日期：2015-11-19 00:00:00
abstract：:Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK12 loss is enriched...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.04.034
更新日期：2018-06-14 00:00:00
abstract：:The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90233-2
更新日期：1979-12-01 00:00:00
abstract：:Understanding human embryonic ventral midbrain is of major interest for Parkinson's disease. However, the cell types, their gene expression dynamics, and their relationship to commonly used rodent models remain to be defined. We performed single-cell RNA sequencing to examine ventral midbrain development in human and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.09.027
更新日期：2016-10-06 00:00:00
abstract：:A new rhythm mutation was isolated based on its elimination of per-controlled luciferase cycling. Levels of period or timeless clock gene products in the mutant are flat in daily light-dark cycles or constant darkness (although PER and TIM oscillate normally in temperature cycles). Consistent with the fact that light ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81638-4
更新日期：1998-11-25 00:00:00
abstract：:PD-1 immune checkpoint blockade provides significant clinical benefits for melanoma patients. We analyzed the somatic mutanomes and transcriptomes of pretreatment melanoma biopsies to identify factors that may influence innate sensitivity or resistance to anti-PD-1 therapy. We find that overall high mutational loads a...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.02.065
更新日期：2016-03-24 00:00:00
abstract：:Pathogenic Vibrio cholerae remains a major human health concern. V. cholerae has a characteristic curved rod morphology, with a longer outer face and a shorter inner face. The mechanism and function of this curvature were previously unknown. Here, we identify and characterize CrvA, the first curvature determinant in V...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.12.019
更新日期：2017-01-12 00:00:00
abstract：:A 1.1 kb intron containing an open reading frame (ORF) in one allele (omega+) of the yeast mitochondrial 21S rRNA gene is nearly quantitatively inserted in crosses into a 21S rRNA allele lacking that intron (omega-). We have determined that this nonreciprocal exchange initiates soon after cells fuse to form zygotes an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90348-4
更新日期：1985-04-01 00:00:00
abstract：:Understanding molecular mechanisms that dictate B cell diversity is important for targeting B cells as anti-cancer treatment. Through the single-cell dissection of B cell heterogeneity in longitudinal samples of patients with breast cancer before and after neoadjuvant chemotherapy, we revealed that an ICOSL+ B cell su...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.02.015
更新日期：2020-03-19 00:00:00
abstract：:The achaete-scute gene complex (AS-C), involved in differentiation of the sensory chaetes of D. melanogaster, and the yellow locus have been cloned. The yellow locus is the most distal and is followed, proximally, by the achaete and the scute loci. In the scute locus (75 kb), three transcription units separated by lon...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90147-3
更新日期：1985-02-01 00:00:00
abstract：:The membrane-bound form of immunoglobulin serves as an antigen-specific receptor for B cells mediating signal transduction and antigen presentation. We have developed an assay that reconstitutes both these physiologic responses with respect to the antigen phosphorylcholine. By introducing specific mutations in the hum...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90171-a
更新日期：1990-10-19 00:00:00
abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80121-x
更新日期：1996-08-09 00:00:00
abstract：:Nuclear and cytoplasmic poly(A)-binding proteins have been purified from Saccharomyces cerevisiae, and antisera have been used to isolate a gene that encodes them. The gene occurs in a single copy on chromosome 5 and gives rise to a unique, unspliced 2.1 kb transcript. The nuclear protein appears to be derived from th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90557-x
更新日期：1986-06-20 00:00:00
abstract：:The budding yeast, Saccharomyces cerevisiae, has emerged as an archetype of eukaryotic cell biology. Here we show that S. cerevisiae is also a model for the evolution of cooperative behavior by revisiting flocculation, a self-adherence phenotype lacking in most laboratory strains. Expression of the gene FLO1 in the la...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.09.037
更新日期：2008-11-14 00:00:00
abstract：:The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which unde...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.10.033
更新日期：2019-11-27 00:00:00
abstract：:An important signaling pathway to the actin cytoskeleton links the Rho family GTPase Cdc42 to the actin-nucleating Arp2/3 complex through N-WASP. Nevertheless, these previously identified components are not sufficient to mediate Cdc42-induced actin polymerization in a physiological context. In this paper, we describe ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.06.027
更新日期：2004-07-23 00:00:00
abstract：:A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.08.020
更新日期：2011-09-02 00:00:00
abstract：:The Gin DNA invertase of bacteriophage Mu carries out processive recombination in which multiple rounds of exchange follow synaptic complex formation. The stereostructure of the knotted products determined by electron microscopy establishes critical features of site synapsis and DNA exchange. Surprisingly, the inverta...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90372-l
更新日期：1990-07-27 00:00:00
abstract：:Two precursor cell subpopulations have been isolated from the spleen cells of nonimmune mice. The major B cell subpopulation binds high levels of the J11D monoclonal antibody and, upon T cell-dependent antigenic stimulation, gives rise to primary antibody-forming cell clones but not secondary B cells. A minority of th...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90761-7
更新日期：1989-12-22 00:00:00
abstract：:We describe a new repressible binary expression system based on the regulatory genes from the Neurospora qa gene cluster. This "Q system" offers attractive features for transgene expression in Drosophila and mammalian cells: low basal expression in the absence of the transcriptional activator QF, high QF-induced expre...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.02.025
更新日期：2010-04-30 00:00:00
abstract：:Bacteria can respond to adverse environmental conditions by drastically reducing or even ceasing metabolic activity. They must then determine that conditions have improved before exiting dormancy, and one indication of such a change is the growth of other bacteria in the local environment. Growing bacteria release mur...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.08.039
更新日期：2008-10-31 00:00:00
abstract：:Cells producing avian sarcoma virus (ASV) contain at least three virus-specific mRNAs, two of which are encoded within the 3' half of the viral genome. Each of these viral RNAs can hybridize with single-stranded DNA(cDNA5') that is complementary to a sequence of 101 nucleotides found at the 5' terminus of the ASV geno...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90084-3
更新日期：1978-09-01 00:00:00
abstract：:Developing cells of the cellular slime mold Dictyostelium discoideum release a low molecular weight metabolite (Slug Turning Factor, STF) which, at high uniform concentrations, interferes with phototaxis and thermotaxis by D. discoideum slugs. D. discoideum slugs migrating in darkness are repelled by (exhibit negative...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90444-x
更新日期：1981-03-01 00:00:00
abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90125-4
更新日期：1985-09-01 00:00:00
abstract：:Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.01.021
更新日期：2007-02-09 00:00:00
abstract：:Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential increase in PTM identification. However, the functional significance of the vast majority of these modifications remains unknown. To address this problem, we compiled ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.05.036
更新日期：2012-07-20 00:00:00
