Screening Human Embryos for Polygenic Traits Has Limited Utility.


:The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which undermines discussion of associated ethical concerns. Here, we use theory, simulations, and real data to evaluate the potential gain of embryo screening, defined as the difference in trait value between the top-scoring embryo and the average embryo. The gain increases very slowly with the number of embryos but more rapidly with the variance explained by the score. Given current technology, the average gain due to screening would be ≈2.5 cm for height and ≈2.5 IQ points for cognitive ability. These mean values are accompanied by wide prediction intervals, and indeed, in large nuclear families, the majority of children top-scoring for height are not the tallest.






Karavani E,Zuk O,Zeevi D,Barzilai N,Stefanis NC,Hatzimanolis A,Smyrnis N,Avramopoulos D,Kruglyak L,Atzmon G,Lam M,Lencz T,Carmi S




Has Abstract


2019-11-27 00:00:00
















  • Mitochondria--a nexus for aging, calorie restriction, and sirtuins?

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    pub_type: 杂志文章,评审


    authors: Guarente L

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  • CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate.

    abstract::We have isolated and characterized a set of overlapping cDNA clones that encode the human centromere autoantigen centromere protein C (CENP-C). The identity of these clones has been established using several criteria. First, they were shown to encode a polypeptide that migrates at the expected position for CENP-C on S...


    pub_type: 杂志文章


    authors: Saitoh H,Tomkiel J,Cooke CA,Ratrie H 3rd,Maurer M,Rothfield NF,Earnshaw WC

    更新日期:1992-07-10 00:00:00

  • AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.

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    pub_type: 杂志文章


    authors: Vasudevan S,Steitz JA

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  • Wnt signaling: multivesicular bodies hold GSK3 captive.

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    pub_type: 评论,杂志文章


    authors: Niehrs C,Acebron SP

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  • N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

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    pub_type: 杂志文章


    authors: Wang X,Zhao BS,Roundtree IA,Lu Z,Han D,Ma H,Weng X,Chen K,Shi H,He C

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    pub_type: 杂志文章


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  • An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array.

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    pub_type: 杂志文章


    authors: McPherson CE,Shim EY,Friedman DS,Zaret KS

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  • A split promoter for a eucaryotic tRNA gene.

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    pub_type: 杂志文章


    authors: Hofstetter H,Kressman A,Birnstiel ML

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  • C-factor: a cell-cell signaling protein required for fruiting body morphogenesis of M. xanthus.

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    pub_type: 杂志文章


    authors: Kim SK,Kaiser D

    更新日期:1990-04-06 00:00:00

  • Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

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    pub_type: 杂志文章


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  • Reassessment of Exosome Composition.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Zhang X,Yan C,Hang J,Finci LI,Lei J,Shi Y

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    pub_type: 杂志文章


    authors: Pavlakis GN,Lockard RE,Vamvakopoulos N,Rieser L,RajBhandary UL,Vournakis JN

    更新日期:1980-01-01 00:00:00

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    pub_type: 杂志文章


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  • The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • The tra-1 gene determines sexual phenotype cell-autonomously in C. elegans.

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    pub_type: 杂志文章


    authors: Hunter CP,Wood WB

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    pub_type: 杂志文章


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  • Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • Fueling synapses.

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    pub_type: 评论,杂志文章


    authors: Schuman E,Chan D

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    pub_type: 杂志文章


    authors: O'Connell KF,Caron C,Kopish KR,Hurd DD,Kemphues KJ,Li Y,White JG

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    pub_type: 杂志文章


    authors: Ohinata Y,Ohta H,Shigeta M,Yamanaka K,Wakayama T,Saitou M

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    pub_type: 评论,杂志文章


    authors: Ridaura V,Belkaid Y

    更新日期:2015-04-09 00:00:00

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    pub_type: 杂志文章


    authors: Van Ness BG,Weigert M,Coleclough C,Mather EL,Kelley DE,Perry RP

    更新日期:1981-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Micheau O,Tschopp J

    更新日期:2003-07-25 00:00:00

  • Membrane hemifusion: crossing a chasm in two leaps.

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    pub_type: 杂志文章,评审


    authors: Chernomordik LV,Kozlov MM

    更新日期:2005-11-04 00:00:00