Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".

abstract：:We have used monoclonal antibodies to detect developmentally regulated cell surface antigens on D. discoideum amebae. A study of an antigen detected using an antibody produced by a hybridoma line implicates a previously undescribed component in the process of cell aggregation. This antigen (consisting of a doublet of ...

journal_title：Cell

authors： Brodie C,Klein C,Swierkosz J

更新日期：1983-04-01 00:00:00

abstract：:N(6)-methyladenosine (m(6)A) is the most abundant internal modification of messenger RNA. While the presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates processing of nuclear transcripts has not been identified. We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-be...

journal_title：Cell

authors： Alarcón CR,Goodarzi H,Lee H,Liu X,Tavazoie S,Tavazoie SF

更新日期：2015-09-10 00:00:00

abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...

journal_title：Cell

authors： Wilson VL,Jones PA

更新日期：1983-01-01 00:00:00

abstract：:In the SV40-transformed mouse embryo fibroblast cell line SVT2/S, genomic rearrangements involving the SV40 DNA and flanking host sequences were identified by Southern blot hybridization using viral DNA as probe. No rearrangements of SV40 DNA integrated into nonpermissive mouse cells have been previously described. Th...

journal_title：Cell

authors： Sager R,Anisowicz A,Howell N

更新日期：1981-01-01 00:00:00

abstract：:Using cryo-electron microscopy, we have solved the structure of an icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum (ER) coassembled from purified cargo adaptor Sec23-24 and Sec13-31 lattice-forming complexes. The coat structure shows a tetrameric assembly of the Sec23-24 adaptor la...

journal_title：Cell

authors： Stagg SM,LaPointe P,Razvi A,Gürkan C,Potter CS,Carragher B,Balch WE

更新日期：2008-08-08 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of request of the editors. Cell is retracting this paper reporting structures of a poxvirus protein, VCP, that inhi...

journal_title：Cell

authors： Murthy KH,Smith SA,Ganesh VK,Judge KW,Mullin N,Barlow PN,Ogata CM,Kotwal GJ

更新日期：2001-01-26 00:00:00

abstract：:Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for neural development, and brain cells frequently contain somatic genomic variations that might involve DSB intermediates. We now use an unbiased, high-throughput approach to identify genomic regions harboring recurrent DSBs in primar...

journal_title：Cell

authors： Wei PC,Chang AN,Kao J,Du Z,Meyers RM,Alt FW,Schwer B

更新日期：2016-02-11 00:00:00

abstract：:Csm, a type III-A CRISPR-Cas interference complex, is a CRISPR RNA (crRNA)-guided RNase that also possesses target RNA-dependent DNase and cyclic oligoadenylate (cOA) synthetase activities. However, the structural features allowing target RNA-binding-dependent activation of DNA cleavage and cOA generation remain unkno...

journal_title：Cell

authors： You L,Ma J,Wang J,Artamonova D,Wang M,Liu L,Xiang H,Severinov K,Zhang X,Wang Y

更新日期：2019-01-10 00:00:00

abstract：:The transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homolog (pp60c-src) are demonstrated to be phosphorylated at serine 12 in vivo under certain conditions. We propose that protein kinase C is responsible for this modification based on the following evidence. First, the tumor promoters, ...

journal_title：Cell

authors： Gould KL,Woodgett JR,Cooper JA,Buss JE,Shalloway D,Hunter T

更新日期：1985-10-01 00:00:00

abstract：:We examine the interaction between polyoma-virus-encoded middle tumor antigen and the cellular src gene product, pp60c-src, using a series of monoclonal antibodies that recognize mammalian pp60c-src. Our results show that infection of mouse cells with transformation-competent strains of polyoma virus results in the st...

journal_title：Cell

authors： Bolen JB,Thiele CJ,Israel MA,Yonemoto W,Lipsich LA,Brugge JS

更新日期：1984-10-01 00:00:00

abstract：:Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we ...

journal_title：Cell

authors： Carrillo-Reid L,Han S,Yang W,Akrouh A,Yuste R

更新日期：2019-07-11 00:00:00

abstract：:Recessive lethal mutations in the T/t-complex of the mouse characteristically show defective genetic complementation, even when they affect very different stages of embryogenesis and are known to be nonallelic. To address the question of their genetic or functional relationship, we have applied the cis-trans test, usi...

journal_title：Cell

authors： Shin HS,McCormick P,Artzt K,Bennett D

更新日期：1983-07-01 00:00:00

abstract：:The yeast plasmid 2 micron circle actively maintains high but stable copy levels in the cell, even though the plasmid confers no selective advantage to its host. To address the mechanism by which stable copy control is achieved, we have examined the level of expression of the genes resident on the yeast plasmid 2 micr...

journal_title：Cell

authors： Som T,Armstrong KA,Volkert FC,Broach JR

更新日期：1988-01-15 00:00:00

abstract：:22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A(+/-) mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain microRNAs. Here, we show a drastic reduction of miR-185, which resides within...

journal_title：Cell

authors： Xu B,Hsu PK,Stark KL,Karayiorgou M,Gogos JA

更新日期：2013-01-17 00:00:00

abstract：:We have established the DNA sequence of nine yeast mutants that prevent the expression either of the split cytochrome b gene alone (five mutants) or of two split genes, the cytochrome b gene and the cytochrome oxidase subunit I gene (four mutants). All the mutations analyzed are localized in intron 14 of the cob-box g...

journal_title：Cell

authors： De La Salle H,Jacq C,Slonimski PP

更新日期：1982-04-01 00:00:00

abstract：:The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how antibodies achieve such neutralization, we isolated CD4-binding-site (CD4bs) antibodies and analyzed 16 co-crystal structures -8 de...

journal_title：Cell

authors： Zhou T,Lynch RM,Chen L,Acharya P,Wu X,Doria-Rose NA,Joyce MG,Lingwood D,Soto C,Bailer RT,Ernandes MJ,Kong R,Longo NS,Louder MK,McKee K,O'Dell S,Schmidt SD,Tran L,Yang Z,Druz A,Luongo TS,Moquin S,Srivatsan S,

更新日期：2015-06-04 00:00:00

abstract：:S. cerevisiae strains containing RAS2val19, a RAS2 gene with a missense mutation analogous to one that activates the transforming potential of mammalian ras genes, have growth and biochemical properties strikingly similar to yeast strains carrying IAC or bcy1. Yeast strains carrying the IAC mutation have elevated leve...

journal_title：Cell

authors： Toda T,Uno I,Ishikawa T,Powers S,Kataoka T,Broek D,Cameron S,Broach J,Matsumoto K,Wigler M

更新日期：1985-01-01 00:00:00

abstract：:Hybrids between mouse hepatoma cells (which secrete several serum proteins) and mouse or rat fibroblasts (which do not secrete these proteins) produce transferrin and the third component of complement (C3) like the parental hepatoma cells, while they do not secrete either albumin or alpha-fetoprotein (AFP). This lack ...

journal_title：Cell

authors： Szpirer J,Szpirer C

更新日期：1975-09-01 00:00:00

abstract：:The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate cancer has hampered progress in understanding disease pathogenesis and therapy response. Using a 3D organoid system, we report success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells....

journal_title：Cell

authors： Gao D,Vela I,Sboner A,Iaquinta PJ,Karthaus WR,Gopalan A,Dowling C,Wanjala JN,Undvall EA,Arora VK,Wongvipat J,Kossai M,Ramazanoglu S,Barboza LP,Di W,Cao Z,Zhang QF,Sirota I,Ran L,MacDonald TY,Beltran H,Mosquera J

更新日期：2014-09-25 00:00:00

abstract：:We used clinical tissue from lethal metastatic castration-resistant prostate cancer (CRPC) patients obtained at rapid autopsy to evaluate diverse genomic, transcriptomic, and phosphoproteomic datasets for pathway analysis. Using Tied Diffusion through Interacting Events (TieDIE), we integrated differentially expressed...

journal_title：Cell

authors： Drake JM,Paull EO,Graham NA,Lee JK,Smith BA,Titz B,Stoyanova T,Faltermeier CM,Uzunangelov V,Carlin DE,Fleming DT,Wong CK,Newton Y,Sudha S,Vashisht AA,Huang J,Wohlschlegel JA,Graeber TG,Witte ON,Stuart JM

更新日期：2016-08-11 00:00:00

abstract：:In a culture system where a bifurcated Aplysia sensory neuron makes synapses with two motor neurons, repeated application of serotonin (5-HT) to one synapse produces a CREB-mediated, synapse-specific, long-term facilitation, which can be captured at the opposite synapse by a single pulse of 5-HT. Repeated pulses of 5-...

journal_title：Cell

authors： Casadio A,Martin KC,Giustetto M,Zhu H,Chen M,Bartsch D,Bailey CH,Kandel ER

更新日期：1999-10-15 00:00:00

abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...

journal_title：Cell

authors： Ruzzo EK,Pérez-Cano L,Jung JY,Wang LK,Kashef-Haghighi D,Hartl C,Singh C,Xu J,Hoekstra JN,Leventhal O,Leppä VM,Gandal MJ,Paskov K,Stockham N,Polioudakis D,Lowe JK,Prober DA,Geschwind DH,Wall DP

更新日期：2019-08-08 00:00:00

abstract：:Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the prot...

journal_title：Cell

authors： Crews ST,Thomas JB,Goodman CS

更新日期：1988-01-15 00:00:00

abstract：:The pluripotential hemopoietic stem cells (CFU-S) of genetically resistant Fv2rr adult C57BL/6 (B6) mice can be persistently infected by Friend virus (FV) when exposed to defective spleen focus-forming virus (SFFV) and helper virus (LLV) at the time of transplantation into heavily irradiated syngeneic recipients (that...

journal_title：Cell

authors： Eckner RJ,Hettrick KL,Greenberger JS,Bennett M

更新日期：1982-12-01 00:00:00

abstract：:A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphoryl...

journal_title：Cell

authors： Ginty DD,Bonni A,Greenberg ME

更新日期：1994-06-03 00:00:00

abstract：:AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are ...

journal_title：Cell

authors： Shi S,Hayashi Y,Esteban JA,Malinow R

更新日期：2001-05-04 00:00:00

abstract：:We show that a functional component of the C. elegans mitotic machinery regulates X chromosome gene expression. This protein, MIX-1, is a member of the dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene expression during interphase. MIX-1 also associates with...

journal_title：Cell

authors： Lieb JD,Albrecht MR,Chuang PT,Meyer BJ

更新日期：1998-01-23 00:00:00

abstract：:The somatic 5S DNA from X. borealis (Xbs 5S DNA) and X. laevis (Xis 5S DNA) and a minor oocyte-specific 5S DNA from X. laevis (Xit 5S DNA) have been purified, and individual repeating units have been cloned and sequenced. The two somatic 5S DNAs differ from the major oocyte 5S DNAs in having GC-rich spacers, homogeneo...

journal_title：Cell

authors： Peterson RC,Doering JL,Brown DD

更新日期：1980-05-01 00:00:00

abstract：:Phosphodiesterases (PDEs) regulate the local concentration of 3',5' cyclic adenosine monophosphate (cAMP) within cells. cAMP activates the cAMP-dependent protein kinase (PKA). In patients, PDE inhibitors have been linked to heart failure and cardiac arrhythmias, although the mechanisms are not understood. We show that...

journal_title：Cell

authors： Lehnart SE,Wehrens XH,Reiken S,Warrier S,Belevych AE,Harvey RD,Richter W,Jin SL,Conti M,Marks AR

更新日期：2005-10-07 00:00:00

abstract：:The TDS4 gene of S. cerevisiae was isolated as an allele-specific high copy suppressor of mutations within the basic region of the TATA-binding protein (TBP). The gene is essential for viability and encodes a 596 aa protein. The first 300 aa of the TDS4 protein exhibit significant sequence similarity to the RNA polyme...

journal_title：Cell

authors： Buratowski S,Zhou H

更新日期：1992-10-16 00:00:00