Abstract：
:22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A(+/-) mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain microRNAs. Here, we show a drastic reduction of miR-185, which resides within the 22q11.2 locus, to levels more than expected by a hemizygous deletion, and we demonstrate that this reduction alters dendritic and spine development. miR-185 represses, through an evolutionarily conserved target site, a previously unknown inhibitor of these processes that resides in the Golgi apparatus and shows higher prenatal brain expression. Sustained derepression of this inhibitor after birth represents the most robust transcriptional disturbance in the brains of Df(16)A(+/-) mice and results in structural alterations in the hippocampus. Reduction of miR-185 also has milder age- and region-specific effects on the expression of some Golgi-related genes. Our findings illuminate the contribution of microRNAs in psychiatric disorders and cognitive dysfunction.
journal_name
Celljournal_title
Cellauthors
Xu B,Hsu PK,Stark KL,Karayiorgou M,Gogos JAdoi
10.1016/j.cell.2012.11.052subject
Has Abstractpub_date
2013-01-17 00:00:00pages
262-75issue
1-2eissn
0092-8674issn
1097-4172pii
S0092-8674(12)01440-7journal_volume
152pub_type
杂志文章相关文献
CELL文献大全abstract：:Four major receptor families enable cells to respond to chemical and physical signals from their proximal environment. The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all allosteric proteins that carry multiple, spatially distinct, y...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.08.015
更新日期：2016-08-25 00:00:00
abstract：:Dysfunctional mitochondria accumulate in many human diseases. Accordingly, mitophagy, which removes these mitochondria through lysosomal degradation, is attracting broad attention. Due to uncertainties in the operational principles of conventional mitophagy probes, however, the specificity and quantitativeness of thei...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.04.025
更新日期：2020-05-28 00:00:00
abstract：:During neural tube closure and spinal cord development, many cells die in both the central and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived professional phagocytes have not yet colonized the trunk region during early neurogenesis. How apoptotic cells are removed from this region dur...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.08.001
更新日期：2019-09-19 00:00:00
abstract：:Distinct classes of neurons are generated at defined positions in the ventral neural tube in response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription factors expressed by neural progenitors act as intermediaries in Shh-dependent neural patterning. These homeodomain factors fall into ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80853-3
更新日期：2000-05-12 00:00:00
abstract：:We have prepared three monoclonal antibodies against human epidermal keratins. These antibodies were highly specific for keratins and, in combination, recognized all major epidermal keratins of several mammalian species. We have used these antibodies to study the tissue distribution of epidermis-related keratins. In v...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90234-3
更新日期：1982-09-01 00:00:00
abstract：:Treating B16 mouse melanoma cells with monoclonal antibody NORM-2 reduces cell growth in tissue culture, agar, and syngeneic mice. We show that the NORM-2 antibody recognizes an integral 83 kd glycoprotein that is mobile in the plane of the plasma membrane of B16 melanoma cells. Expression of the glycoprotein is reduc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90510-6
更新日期：1986-12-05 00:00:00
abstract：:A recombinant peptide encoding the CD11b A domain bound 54Mn2+ with a high affinity. Other divalent cations, including Mg2+, Zn2+, Ni2+, Co2+, and Cd2+, but not Ca2+ or Ba2+, competed effectively for Mn2+ binding. Amino acid substitutions within two conserved and noncontiguous regions in the recombinant peptide abolis...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90575-b
更新日期：1993-03-26 00:00:00
abstract：:Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and w...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00762-6
更新日期：2002-06-14 00:00:00
abstract：:Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28 degrees C-30 degrees C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18 degrees C only a mild Notch phenotype is evident. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.12.016
更新日期：2008-01-25 00:00:00
abstract：:The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how conf...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.01.007
更新日期：2015-02-12 00:00:00
abstract：:An acute but transient response to insulin is essential for glucose homeostasis in mammals. Chakraborty et al. (2010) uncover a new feedback mechanism regulating insulin signaling. They show that the inositol pyrophosphate IP7, which is produced in response to insulin, inhibits the Akt kinase, a primary effector of in...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.11.040
更新日期：2010-12-10 00:00:00
abstract：:In the ciliated protozoan Paramecium tetraurelia, Piwi-associated small RNAs are generated upon the elimination of tens of thousands of short transposon-derived DNA segments as part of development. These RNAs then target complementary DNA for elimination in a positive feedback process, contributing to germline defense...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.02.020
更新日期：2017-03-09 00:00:00
abstract：:Radioactive alpha factor is degraded to discrete biologically inactive fragments by the target a cells of S. cerevisiae, but not by alpha cells which make the pheromone. The pattern of cleavage products and sequence analysis of one fragment indicated that the first scission occurred between leucine 6 and lysine 7. The...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90117-x
更新日期：1979-11-01 00:00:00
abstract：:Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional fronts by generating long-range diffusible inhibitors or by sequestering essential polarity components. We use morphologica...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.10.050
更新日期：2012-01-20 00:00:00
abstract：:We demonstrate that mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two inherited conditions characterized by altered calcium homeostasis. The Ca(2+)-sensing receptor belongs to the superfamily of seven membrane-spann...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90617-y
更新日期：1993-12-31 00:00:00
abstract：:Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes in clinical trials' design and conduct, and we forecast future directions towa...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.01.027
更新日期：2017-02-09 00:00:00
abstract：:The axonal shafts of neurons contain bundled microtubules, whereas extending growth cones contain unbundled microtubule filaments, suggesting that localized activation of microtubule-associated proteins (MAP) at the transition zone may bundle these filaments during axonal growth. Dephosphorylation is thought to lead t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.03.023
更新日期：2007-05-04 00:00:00
abstract：:Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2008.01.007
更新日期：2008-01-25 00:00:00
abstract：:In two companion reports, the TRACERx consortium investigates tumor heterogeneity and evolution in early-stage non-small cell lung cancer. The studies highlight the prognostic value of copy-number heterogeneity assessment in tumor biopsies and circulating tumor DNA detection in plasma and suggest that tracking the evo...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2017.05.001
更新日期：2017-05-18 00:00:00
abstract：:Telomeres are thought to be maintained by the preferential recruitment of telomerase to the shortest telomeres. The extension of the G-rich telomeric strand by telomerase is also believed to be coordinated with the complementary synthesis of the C strand by the conventional replication machinery. However, we show that...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.05.026
更新日期：2009-08-07 00:00:00
abstract：:Extraction of glycerinated chicken skeletal muscle with 0.6 M potassium iodide leaves a framework of insoluble components within each muscle fiber. This framework is composed primarily of planes of in-register Z discs that have been thickened by the accumulation of material on both sides of each disc during extraction...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90051-x
更新日期：1978-12-01 00:00:00
abstract：:The mechanism by which cells decide to skip mitosis to become polyploid is largely undefined. Here we used a high-content image-based screen to identify small-molecule probes that induce polyploidization of megakaryocytic leukemia cells and serve as perturbagens to help understand this process. Our study implicates fi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.06.032
更新日期：2012-08-03 00:00:00
abstract：:Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have origin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.08.023
更新日期：2010-09-03 00:00:00
abstract：:The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how antibodies achieve such neutralization, we isolated CD4-binding-site (CD4bs) antibodies and analyzed 16 co-crystal structures -8 de...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.05.007
更新日期：2015-06-04 00:00:00
abstract：:Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components of this pathway have been previously generated and studied in vitro, the assembly of this multi-synaptic circuit has not yet been achieved with human cells. Here...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.11.017
更新日期：2020-12-23 00:00:00
abstract：:The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype includes severe craniofac...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81732-8
更新日期：1998-09-18 00:00:00
abstract：:Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. In yeast, they also interact with active genes, attracting or retaining them at the nuclear periphery. In higher eukaryotes, some NPC components (nucleoporins) are also found in the nucleoplasm, with a so far unknown function. We have functio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.01.011
更新日期：2010-02-05 00:00:00
abstract：:Induction of senescence permanently restricts cellular proliferation after oncogenic stimulation thereby acting as a potent barrier to tumor development. The relevant effector proteins may therefore be fundamental to cancer development. A recent study identified IGFBP7 as a secreted factor mediating melanocyte senesce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.04.021
更新日期：2010-05-14 00:00:00
abstract：:Immunologically privileged sites express Fas ligand (FasL), which protects them from attack by activated T cells that express Fas and die upon contact with FasL. In an attempt to protect nonobese diabetic mice (NOD) from autoimmune diabetes, we made FasL transgenic NOD mice using the beta cell-specific rat insulin-1 p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80178-6
更新日期：1997-04-04 00:00:00
abstract：:Developing cells of the cellular slime mold Dictyostelium discoideum release a low molecular weight metabolite (Slug Turning Factor, STF) which, at high uniform concentrations, interferes with phototaxis and thermotaxis by D. discoideum slugs. D. discoideum slugs migrating in darkness are repelled by (exhibit negative...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90444-x
更新日期：1981-03-01 00:00:00
