Abstract：
:Treating B16 mouse melanoma cells with monoclonal antibody NORM-2 reduces cell growth in tissue culture, agar, and syngeneic mice. We show that the NORM-2 antibody recognizes an integral 83 kd glycoprotein that is mobile in the plane of the plasma membrane of B16 melanoma cells. Expression of the glycoprotein is reduced under conditions that inhibit B16 growth, such as low serum, high cell density, and addition of transforming growth factor-beta. The glycoprotein reappears during S phase, when growth-arrested cells are restimulated. The NORM-2 antigen appears to be involved in growth regulation of B16 melanoma cells both in vitro and in vivo.
journal_name
Celljournal_title
Cellauthors
Wieland I,Müller G,Braun S,Birchmeier Wdoi
10.1016/0092-8674(86)90510-6subject
Has Abstractpub_date
1986-12-05 00:00:00pages
675-85issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(86)90510-6journal_volume
47pub_type
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