Abstract：
:The globin and immunoglobulin multigene families have been used to study the effect of chromosomal organization on the time of gene replication. Some of the genes are late-replicating, providing the first identification of late-replicating sequences that are not highly repetitive. One is a member of the mouse alpha-globin gene family, which consists of genes mapping to three different chromosomes. The other genes in this family replicate early during S. Our studies demonstrate that immunoglobulin gene rearrangements and rearrangements between these genes and the c-myc oncogene are accompanied by dramatic differences in their temporal order of replication. We conclude that a gene's position in the chromosome, rather than its sequence, determines the time of replication. We suggest that the differences in association with gene rearrangement result from changes in the proximity of the affected gene to sites that control the temporal order of replication during S.
journal_name
Celljournal_title
Cellauthors
Calza RE,Eckhardt LA,DelGiudice T,Schildkraut CLdoi
10.1016/0092-8674(84)90349-0subject
Has Abstractpub_date
1984-03-01 00:00:00pages
689-96issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(84)90349-0journal_volume
36pub_type
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