Abstract：
:During neural tube closure and spinal cord development, many cells die in both the central and peripheral nervous systems (CNS and PNS, respectively). However, myeloid-derived professional phagocytes have not yet colonized the trunk region during early neurogenesis. How apoptotic cells are removed from this region during these stages remains largely unknown. Using live imaging in zebrafish, we demonstrate that neural crest cells (NCCs) respond rapidly to dying cells and phagocytose cellular debris around the neural tube. Additionally, NCCs have the ability to enter the CNS through motor exit point transition zones and clear debris in the spinal cord. Surprisingly, NCCs phagocytosis mechanistically resembles macrophage phagocytosis and their recruitment toward cellular debris is mediated by interleukin-1β. Taken together, our results reveal a role for NCCs in phagocytosis of debris in the developing nervous system before the presence of professional phagocytes.
journal_name
Celljournal_title
Cellauthors
Zhu Y,Crowley SC,Latimer AJ,Lewis GM,Nash R,Kucenas Sdoi
10.1016/j.cell.2019.08.001subject
Has Abstractpub_date
2019-09-19 00:00:00pages
74-89.e10issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(19)30889-Xjournal_volume
179pub_type
杂志文章相关文献
CELL文献大全abstract：:Academic travel has a substantial carbon footprint. The ongoing pandemic has propelled the development and adoption of technologies for online delivery of seminars and remote attendance at scientific conferences. This should not lead to the complete elimination of in-person events, but the scientific community must se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.07.026
更新日期：2020-08-20 00:00:00
abstract：:We describe the purification and characterization of ACF, an ATP-utilizing chromatin assembly and remodeling factor. ACF is a multisubunit factor that contains ISWI protein and is distinct from NURF, another ISWI-containing factor. In chromatin assembly, purified ACF and a core histone chaperone (such as NAP-1 or CAF-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80321-9
更新日期：1997-07-11 00:00:00
abstract：:We have isolated the genes encoding the largest subunit of all three classes of RNA polymerase from Trypanosoma brucei. While the pol II largest subunit is encoded by a single gene in all organisms examined to date, trypanosomes contain two copies of the gene. Both genes are expressed in the procyclic and bloodstream ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90686-7
更新日期：1989-03-10 00:00:00
abstract：:To test the functional consequence of phosphorylation of the EGF receptor at Thr 654 by protein kinase C, the normal Thr 654 human EGF receptor cDNA or a mutant encoding an Ala 654 were expressed in heterologous cells. In cell lines expressing both the Thr 654 and Ala 654 receptors, functional cell-surface Thr 654 rec...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90006-1
更新日期：1986-03-28 00:00:00
abstract：:Constitutive cell-autonomous immunity in metazoans predates interferon-inducible immunity and comprises primordial innate defense. Phagocytes mobilize interferon-inducible responses upon engagement of well-characterized signaling pathways by pathogen-associated molecular patterns (PAMPs). The signals controlling deplo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.09.034
更新日期：2017-11-02 00:00:00
abstract：:Mutations at the X-linked disconnected locus of D. melanogaster lead to the failure of adult photoreceptor axons to innervate their target cells in the developing optic lobes of the third instar larva, resulting in flies that have rudimentary optic ganglia. The cascade of epigenetic events leading to the adult disconn...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90180-2
更新日期：1987-09-25 00:00:00
abstract：:The ELH prohormone is proteolytically processed into at least nine peptides which govern egg-laying behavior in Aplysia. Quantitative immunocytochemistry demonstrates that peptides derived from the prohormone are packaged into distinct vesicle classes. Further experiments suggest the segregation occurs via a rapid ini...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(88)91131-2
更新日期：1988-09-09 00:00:00
abstract：:Cholera toxin inhibition of progesterone-induced meiosis of Xenopus laevis oocytes in vitro has been correlated with increased cAMP levels. Inhibition of germinal vesicle breakdown (Gvbd) and cAMP increase occurred after a lag period of 2 hr, when cholera toxin was injected, or 4--5 hr, when applied externally. The ab...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90052-1
更新日期：1978-12-01 00:00:00
abstract：:The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.10.016
更新日期：2018-11-29 00:00:00
abstract：:Cells producing avian sarcoma virus (ASV) contain at least three virus-specific mRNAs, two of which are encoded within the 3' half of the viral genome. Each of these viral RNAs can hybridize with single-stranded DNA(cDNA5') that is complementary to a sequence of 101 nucleotides found at the 5' terminus of the ASV geno...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90084-3
更新日期：1978-09-01 00:00:00
abstract：:Mutations in the C. elegans gene ced-3 prevent almost all programmed cell deaths, so that in a ced-3 mutant there are many extra cells. We show that the pharyngeal neuron M4 is essential for feeding in wild-type worms, but in a ced-3 mutant, one of the extra cells, probably MSpaaaaap (the sister of M4), can sometimes ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90593-9
更新日期：1987-12-24 00:00:00
abstract：:Polycomb group (PcG) and trithorax group (trxG) proteins are critical regulators of numerous developmental genes. To silence or activate gene expression, respectively, PcG and trxG proteins bind to specific regions of DNA and direct the posttranslational modification of histones. Recent work suggests that PcG proteins...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2007.02.009
更新日期：2007-02-23 00:00:00
abstract：:The science advisor to the US president has the opportunity to influence how scientific research is supported by the federal government, as well as the ways in which science and technology can be applied to meet the needs of society. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.11.024
更新日期：2009-11-25 00:00:00
abstract：:Cultured preadipose 3T3 cells are induced or enabled to undergo adipose conversion in the presence of an extract of pituitary gland. Adipogenic activity is found in standard growth hormone preparations derived from different species. Further purification of rat growth hormone by several methods does not remove its adi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90440-8
更新日期：1982-07-01 00:00:00
abstract：:The orderly reduction in chromosome number that occurs during meiosis depends on two aspects of chromosome behavior specific to the first meiotic division. These are the retention of cohesion between sister centromeres and their attachment to microtubules that extend to the same pole (monopolar attachment). By deletin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)00217-8
更新日期：2000-12-22 00:00:00
abstract：:Plants rely heavily on environmental cues to control the timing of developmental transitions. We are beginning to better understand what determines the timing of two of these transitions, the switch from juvenile to adult vegetative development and the transition to flowering. In this review, we discuss how RNA silenc...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2006.05.005
更新日期：2006-05-19 00:00:00
abstract：:At early times after adenovirus infection, transcription from all early viral promoters requires the expression of a 289 amino acid phosphoprotein encoded in the pre-early transcription unit E1A. Mutations in E1A result in a marked delay in the induction of early viral transcription. To distinguish between possible mo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90011-9
更新日期：1983-07-01 00:00:00
abstract：:Purified budded virions of Autographa californica nuclear polyhedrosis virus (AcNPV) contain abundant amounts of free ubiquitin, which has an altered electrophoretic mobility on SDS gels as compared with standard ubiquitin. Phase extraction of virion proteins with Triton X-114 indicated that the modified form of ubiqu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90413-1
更新日期：1995-01-27 00:00:00
abstract：:Hox homeodomain proteins are developmental regulators that determine body plan in a variety of organisms. A majority of the vertebrate Hox proteins bind DNA as heterodimers with the Pbx1 homeodomain protein. We report here the 2.35 A structure of a ternary complex containing a human HoxB1-Pbx1 heterodimer bound to DNA...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80662-5
更新日期：1999-02-19 00:00:00
abstract：:Polyadenylation of mRNA precursors by poly(A) polymerase depends on a specificity factor, CPF, recognizing the polyadenylation signal AAUAAA. This paper describes an apparently novel poly(A)-binding protein that acts as a second specificity factor, mediating the recognition of the growing poly(A) tail. A transition fr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90119-j
更新日期：1991-08-23 00:00:00
abstract：:Post-translational modifications of histone proteins and exchanges of histone variants of chromatin are central to the regulation of nearly all DNA-templated biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we employ a hig...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.03.079
更新日期：2018-05-31 00:00:00
abstract：:Much like the "microbe hypothesis" put forth over 150 years ago, the "prion hypothesis" can be definitely proven only if a prion disease is engendered in a natural host from an infectious prion produced in vitro. In this issue of Cell, come very close to accomplishing this goal by producing a prion disease in a natura...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2005.04.002
更新日期：2005-04-22 00:00:00
abstract：:In this issue, Frey and Görlich (2007) provide new insight into the selective barrier that controls protein traffic through the nuclear pore complex. They show that a single protein domain of the nuclear pore protein Nsp1 can form a hydrogel that allows highly selective access of nuclear transport receptors and their ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2007.07.029
更新日期：2007-08-10 00:00:00
abstract：:Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable methods to identify and interrogate pathways involved in pancreatic tumorigenesis are urgently needed. We established organoid models from normal and neoplastic murine and human pancreas tiss...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.12.021
更新日期：2015-01-15 00:00:00
abstract：:V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2010.04.014
更新日期：2010-04-30 00:00:00
abstract：:Following EMS mutagenesis we recovered a mutant of D. melanogaster that grows at concentrations of alpha-amanitin lethal to wild-type. To our knowledge this mutant represents the first example of an amanitin-resistant eucaryotic organism. The amanitin resistance of the mutant (AmaC4) is due to an alteration in its DNA...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90116-8
更新日期：1979-11-01 00:00:00
abstract：:Proteolysis by the ubiquitin-proteasome pathway is often regulated, but the mechanisms underlying such regulation remain ill-defined. In Saccharomyces cerevisiae, cell type is controlled by the MAT transcription factors. The alpha2 repressor is a known ubiquitin pathway substrate in alpha haploid cells. We show that a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81421-x
更新日期：1998-07-24 00:00:00
abstract：:The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recen...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2010.01.045
更新日期：2010-02-19 00:00:00
abstract：:Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the mol...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.06.018
更新日期：2008-07-25 00:00:00
abstract：:We describe genetic and physical characterization of rearrangements of chromosome III which result in changes of cell type in S. cerevisiae. Two types of rearrangements were obtained as rare events which caused a change at the locus controlling cell type, MAT, associated with a recessive lethal mutation, in one case f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90050-3
更新日期：1979-10-01 00:00:00
